9FYQ
 
 | | Cryo-EM structure of native SV2A in complex with TeNT-Hc, gangliosides and Pro-Macrobody 5 | | Descriptor: | (2~{R},4~{R},5~{S},6~{S})-2-[(2~{R},3~{R})-3-[(2~{R},3~{S},4~{S},6~{S})-6-[(2~{S},3~{S},4~{R},5~{S},6~{S})-3-[(2~{R},3~{R},4~{R},5~{S},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-2-(hydroxymethyl)-6-[(2~{R},3~{R},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-[2-(octadecanoylamino)-3-oxidanyl-octadec-4-enoxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-5-oxidanyl-oxan-4-yl]oxy-3-azanyl-6-carboxy-4-oxidanyl-oxan-2-yl]-2,3-bis(oxidanyl)propoxy]-5-azanyl-4-oxidanyl-6-[(1~{R},2~{S})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (2~{S},4~{S},5~{R},6~{S})-5-acetamido-2-[(2~{R},3~{R},4~{R},5~{S},6~{R})-2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-4-[(2~{S},4~{S},5~{S},6~{S})-5-acetamido-2-carboxy-4-oxidanyl-6-[(1~{S},2~{R})-1,2,3-tris(oxidanyl)propyl]oxan-2-yl]oxy-6-[(2~{R},3~{S},4~{R},5~{R},6~{R})-6-[2-(docosanoylamino)-3-oxidanyl-octadec-4-enoxy]-2-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-3-yl]oxy-2-(hydroxymethyl)-5-oxidanyl-oxan-3-yl]oxy-6-(hydroxymethyl)-5-oxidanyl-3-(2-oxidanylidenepropyl)oxan-4-yl]oxy-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-4-yl]oxy-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Schenck, S, Brunner, J.D. | | Deposit date: | 2024-07-03 | | Release date: | 2025-05-21 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams.
Nat Commun, 16, 2025
|
|
9FYR
 | |
9G4N
 | | Glycoside Hydrolase Family 157 from Labilibaculum antarcticum (LaGH157) E224A mutant in complex with Laminaritriose and Glucose | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Glycoside hydrolase family 2 catalytic domain-containing protein, ... | | Authors: | Caseiro, C, Alves, V.D, Carvalho, A.L, Bule, P. | | Deposit date: | 2024-07-15 | | Release date: | 2025-05-21 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Family GH157 enzyme exhibits broad linkage tolerance and a dual endo/exo-beta-glucanase activity on beta-glucans.
Int.J.Biol.Macromol., 282, 2024
|
|
1MCO
 | | THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION | | Descriptor: | IGG1 MCG INTACT ANTIBODY (HEAVY CHAIN), IGG1 MCG INTACT ANTIBODY (LIGHT CHAIN), N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-L-gulopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Guddat, L.W, Edmundson, A.B. | | Deposit date: | 1993-02-25 | | Release date: | 1994-01-31 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Three-dimensional structure of a human immunoglobulin with a hinge deletion.
Proc.Natl.Acad.Sci.Usa, 90, 1993
|
|
1MJT
 | | CRYSTAL STRUCTURE OF SANOS, A BACTERIAL NITRIC OXIDE SYNTHASE OXYGENASE PROTEIN, IN COMPLEX WITH NAD+ AND SEITU | | Descriptor: | ETHYLISOTHIOUREA, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NITRIC-OXIDE SYNTHASE HOMOLOG, ... | | Authors: | Bird, L.E, Ren, J, Stammers, D.K. | | Deposit date: | 2002-08-28 | | Release date: | 2003-01-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus
Structure, 10, 2002
|
|
9FYE
 | | Structure of the Sabia Virus spike complex in an open conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein G1, ... | | Authors: | Diskin, R, Cohen-Dvashi, H. | | Deposit date: | 2024-07-03 | | Release date: | 2025-06-11 | | Last modified: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Metal-induced conformational changes in the Sabia virus spike complex.
Nat Microbiol, 10, 2025
|
|
1MQ8
 | | Crystal structure of alphaL I domain in complex with ICAM-1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-L, ... | | Authors: | Shimaoka, M, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, McCormack, A, Zhang, R, Joachimiak, A, Takagi, J, Wang, J.-H, Springer, T.A. | | Deposit date: | 2002-09-15 | | Release date: | 2003-01-14 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
Cell(Cambridge,Mass.), 112, 2003
|
|
9FYG
 | |
9GQQ
 | | influenza neuraminidase N1/19 hybrid | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Bowden, T.A, Paesen, G.C, Rijal, P. | | Deposit date: | 2024-09-09 | | Release date: | 2025-06-11 | | Last modified: | 2025-10-22 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development.
Elife, 14, 2025
|
|
1LXM
 | | Crystal Structure of Streptococcus agalactiae Hyaluronate Lyase Complexed with Hexasaccharide Unit of Hyaluronan | | Descriptor: | HYALURONATE Lyase, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Mello, L.V, de Groot, B.L, Li, S, Jedrzejas, M.J. | | Deposit date: | 2002-06-05 | | Release date: | 2002-10-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan.
J.Biol.Chem., 277, 2002
|
|
9FYA
 | | Structure of the Sabia Virus spike complex in a closed conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein G1, ... | | Authors: | Diskin, R, Cohen-Dvashi, H. | | Deposit date: | 2024-07-03 | | Release date: | 2025-06-11 | | Last modified: | 2025-09-17 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Metal-induced conformational changes in the Sabia virus spike complex.
Nat Microbiol, 10, 2025
|
|
9GQT
 | | influenza neuraminidase hybrid N1/09 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Bowden, T.A, Paesen, G.C. | | Deposit date: | 2024-09-09 | | Release date: | 2025-06-11 | | Last modified: | 2025-09-24 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development.
Elife, 14, 2025
|
|
1LYA
 | | CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATHEPSIN D, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Baldwin, E.T, Bhat, T.N, Gulnik, S, Erickson, J.W. | | Deposit date: | 1993-04-22 | | Release date: | 1994-01-31 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993
|
|
9GQX
 | | influenza neuraminidase mSN1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Pramila, R, Paesen, G.C, Bowden, T.A. | | Deposit date: | 2024-09-10 | | Release date: | 2025-06-11 | | Last modified: | 2025-09-24 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development.
Elife, 14, 2025
|
|
1MPM
 | | MALTOPORIN MALTOSE COMPLEX | | Descriptor: | MAGNESIUM ION, MALTOPORIN, alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | | Authors: | Dutzler, R, Schirmer, T. | | Deposit date: | 1996-01-11 | | Release date: | 1997-03-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway.
Structure, 4, 1996
|
|
8IDO
 | | Crystal structure of nanobody VHH-T148 with MERS-CoV RBD | | Descriptor: | Spike protein S1, VHH-T148, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Wang, X, Tian, L. | | Deposit date: | 2023-02-14 | | Release date: | 2024-02-28 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures and neutralizing mechanisms of camel nanobodies targeting the receptor-binding domain of MERS-CoV spike glycoprotein
To Be Published
|
|
8IDM
 | | Crystal structure of nanobody VHH-227 with nanobody VHH-T71 and MERS-CoV RBD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... | | Authors: | Wang, X, Tian, L. | | Deposit date: | 2023-02-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.59 Å) | | Cite: | Structural Definition of a Novel Nanobody Binding Site specifically targeting the MERS-CoV RBD Core-Domain with Neutralizing Capacity
To Be Published
|
|
1LZR
 | |
1LZY
 | |
8IDI
 | | Crystal structure of nanobody VHH-T71 with MERS-CoV RBD | | Descriptor: | Spike protein S1, VHH-T71, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-3)][alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Wang, X, Tian, L. | | Deposit date: | 2023-02-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Structural Definition of a Novel Nanobody Binding Site specifically targeting the MERS-CoV RBD Core-Domain with Neutralizing Capacity
To Be Published
|
|
1MFD
 | |
1MFV
 | | Probing the role of a mobile loop in human slaivary amylase: Structural studies on the loop-deleted enzyme | | Descriptor: | 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | | Authors: | Ramasubbu, N, Ragunath, C, Mishra, P.J. | | Deposit date: | 2002-08-13 | | Release date: | 2002-11-20 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Probing the role of a mobile loop in substrate binding and enzyme activity of
human salivary amylase.
J.Mol.Biol., 325, 2003
|
|
9G6E
 | | CLC7(Y715C)/OSTM1 complex | | Descriptor: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, H(+)/Cl(-) exchange transporter 7, ... | | Authors: | Lin, Y, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-07-18 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC7
To Be Published
|
|
1MFE
 | |
9G6D
 | | CLC7/OSTM1 complex in the absence of PIP2 lipid. | | Descriptor: | CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, H(+)/Cl(-) exchange transporter 7, ... | | Authors: | Lin, Y, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-07-18 | | Release date: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC7
To Be Published
|
|
