4UXS
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![BU of 4uxs by Molmil](/molmil-images/mine/4uxs) | Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, KINESIN-3 MOTOR DOMAIN, ... | Authors: | Atherton, J, Farabella, I, Yu, I.M, Rosenfeld, S.S, Houdusse, A, Topf, M, Moores, C. | Deposit date: | 2014-08-27 | Release date: | 2014-09-24 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins. Elife, 3, 2014
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8CG3
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4UY1
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![BU of 4uy1 by Molmil](/molmil-images/mine/4uy1) | Novel pyrazole series of group X Secretory Phospholipase A2 (sPLA2-X) inhibitors | Descriptor: | 5-(2,5-DIMETHYL-3-THIENYL)-1H-PYRAZOLE-3-CARBOXAMIDE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Sandmark, J, Oster, L, Hallberg, K, Bodin, C, Chen, H. | Deposit date: | 2014-08-28 | Release date: | 2014-10-15 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of a Novel Pyrazole Series of Group X Secreted Phospholipase A2 Inhibitor (Spla2X) Via Fragment Based Virtual Screening Bioorg.Med.Chem.Lett., 24, 2014
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8BZB
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![BU of 8bzb by Molmil](/molmil-images/mine/8bzb) | co-soak stabilizers for ERa - 14-3-3 interaction (884_AZ275) | Descriptor: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-ethoxy-1-benzothiophene-2-carboximidamide, ... | Authors: | Visser, E.J, Sijbesma, E, Ottmann, C. | Deposit date: | 2022-12-14 | Release date: | 2023-08-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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4V0X
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![BU of 4v0x by Molmil](/molmil-images/mine/4v0x) | The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-684) | Descriptor: | MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT | Authors: | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | Deposit date: | 2014-09-18 | Release date: | 2015-03-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
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8CGG
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5XV1
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![BU of 5xv1 by Molmil](/molmil-images/mine/5xv1) | Crystal structure of ATG101-ATG13HORMA | Descriptor: | Autophagy-related protein 101, Autophagy-related protein 13 | Authors: | Kim, B.-W, Song, H.K. | Deposit date: | 2017-06-26 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.508 Å) | Cite: | Crystal structure of ATG101-ATG13HORMA To Be Published
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8CGH
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8CRH
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![BU of 8crh by Molmil](/molmil-images/mine/8crh) | Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil | Descriptor: | 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Kirkman, T.J, Dias, M.V.B. | Deposit date: | 2023-03-08 | Release date: | 2023-08-02 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. Acta Crystallogr D Struct Biol, 79, 2023
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2A79
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![BU of 2a79 by Molmil](/molmil-images/mine/2a79) | Mammalian Shaker Kv1.2 potassium channel- beta subunit complex | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ... | Authors: | Long, S.B, Campbell, E.B, MacKinnon, R. | Deposit date: | 2005-07-05 | Release date: | 2005-07-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science, 309, 2005
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8CA7
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![BU of 8ca7 by Molmil](/molmil-images/mine/8ca7) | Omadacycline and spectinomycin bound to the 30S ribosomal subunit head | Descriptor: | 16S rRNA, 30S ribosomal protein S7, MAGNESIUM ION, ... | Authors: | Paternoga, H, Crowe-McAuliffe, C, Wilson, D.N. | Deposit date: | 2023-01-24 | Release date: | 2023-08-02 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (2.06 Å) | Cite: | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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5XW5
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8CKF
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![BU of 8ckf by Molmil](/molmil-images/mine/8ckf) | Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand | Descriptor: | 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{R})-oxidanyl(pyridin-3-yl)methyl]phenol, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(~{S})-oxidanyl(pyridin-3-yl)methyl]phenol, Bromodomain-containing protein 4 | Authors: | Thomas, A.M, McDonough, M.A, Schiedel, M, Conway, S.J. | Deposit date: | 2023-02-15 | Release date: | 2023-08-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. Acs Chem.Biol., 18, 2023
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8C3Y
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5X5D
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![BU of 5x5d by Molmil](/molmil-images/mine/5x5d) | Human thymidylate synthase bound with dUMP | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | Authors: | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | Deposit date: | 2017-02-15 | Release date: | 2017-06-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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8COL
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![BU of 8col by Molmil](/molmil-images/mine/8col) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (orthorombic form R4oP-2) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imioloczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | Deposit date: | 2023-02-28 | Release date: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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5X4W
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![BU of 5x4w by Molmil](/molmil-images/mine/5x4w) | Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition | Descriptor: | PHOSPHATE ION, Thymidylate synthase | Authors: | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | Deposit date: | 2017-02-14 | Release date: | 2017-06-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
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8CLZ
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![BU of 8clz by Molmil](/molmil-images/mine/8clz) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (monoclinic form R4mC-2) | Descriptor: | CHLORIDE ION, Putative L-asparaginase II protein, ZINC ION | Authors: | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imiolczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | Deposit date: | 2023-02-17 | Release date: | 2023-08-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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5X5T
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8C76
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![BU of 8c76 by Molmil](/molmil-images/mine/8c76) | Light-state 2.5 Angstrom wild-type X-ray crystal structure of the cobalamin binding domain belonging to a light-dependent transcription regulator TtCarH obtained under aerobic conditions from a form 2 crystal illuminated during 5 s | Descriptor: | COBALAMIN, Probable transcriptional regulator | Authors: | Rios-Santacruz, R, Colletier, J.P, Schiro, G, Weik, M. | Deposit date: | 2023-01-12 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Redox driven B 12 -ligand switch drives CarH photoresponse. Nat Commun, 14, 2023
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5X5Y
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![BU of 5x5y by Molmil](/molmil-images/mine/5x5y) | A membrane protein complex | Descriptor: | Probable ATP-binding component of ABC transporter, Uncharacterized protein | Authors: | Luo, Q, Yang, X, Huang, Y. | Deposit date: | 2017-02-18 | Release date: | 2017-04-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.465 Å) | Cite: | Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG Nat. Struct. Mol. Biol., 24, 2017
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8C73
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![BU of 8c73 by Molmil](/molmil-images/mine/8c73) | Dark state 1.8 Angstrom crystal structure of cobalamin binding domain belonging to a light-dependent transcription regulator TtCarH obtained under aerobic condition form ll | Descriptor: | 5'-DEOXYADENOSINE, COBALAMIN, Probable transcriptional regulator | Authors: | Rios-Santacruz, R, Colletier, J.P, Schiro, G, Weik, M. | Deposit date: | 2023-01-12 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Redox driven B 12 -ligand switch drives CarH photoresponse. Nat Commun, 14, 2023
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8CLY
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![BU of 8cly by Molmil](/molmil-images/mine/8cly) | Crystal structure of Rhizobium etli constitutive L-asparaginase ReAIV (tetragonal form R4tP) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Putative L-asparaginase II protein, ... | Authors: | Loch, J.I, Worsztynowicz, P, Sliwiak, J, Imiolczyk, B, Grzechowiak, M, Gilski, M, Jaskolski, M. | Deposit date: | 2023-02-17 | Release date: | 2023-08-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center. Acta Crystallogr D Struct Biol, 79, 2023
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4W7S
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![BU of 4w7s by Molmil](/molmil-images/mine/4w7s) | Crystal structure of the yeast DEAD-box splicing factor Prp28 at 2.54 Angstroms resolution | Descriptor: | GLYCEROL, HEXAETHYLENE GLYCOL, MAGNESIUM ION, ... | Authors: | Jacewicz, A, Smith, P, Schwer, B, Shuman, S. | Deposit date: | 2014-08-22 | Release date: | 2014-10-29 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.542 Å) | Cite: | Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28. Nucleic Acids Res., 42, 2014
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6OZ6
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![BU of 6oz6 by Molmil](/molmil-images/mine/6oz6) | Crystal structure of MraY bound to 3'-hydroxymureidomycin A | Descriptor: | (2~{S})-2-[[(2~{S})-1-[[(2~{S},3~{S})-3-[[(2~{S})-2-azanyl-3-(3-hydroxyphenyl)propanoyl]-methyl-amino]-1-[[(~{Z})-[(3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-ylidene]methyl]amino]-1-oxidanylidene-butan-2-yl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]carbamoylamino]-3-(3-hydroxyphenyl)propanoic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | Authors: | Mashalidis, E.H, Lee, S.Y. | Deposit date: | 2019-05-15 | Release date: | 2019-07-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Chemical logic of MraY inhibition by antibacterial nucleoside natural products. Nat Commun, 10, 2019
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