7Z37
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![BU of 7z37 by Molmil](/molmil-images/mine/7z37) | Structure of the RAF1-HSP90-CDC37 complex (RHC-II) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... | Authors: | Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. | Deposit date: | 2022-03-01 | Release date: | 2022-09-14 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
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7Z39
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![BU of 7z39 by Molmil](/molmil-images/mine/7z39) | Structure of Belumosudil bound to CK2alpha | Descriptor: | 2-[3-[4-(1~{H}-indazol-5-ylamino)quinazolin-2-yl]phenoxy]-~{N}-propan-2-yl-ethanamide, ACETATE ION, Casein kinase II subunit alpha, ... | Authors: | Brear, P, Hyvonen, M. | Deposit date: | 2022-03-01 | Release date: | 2022-10-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2 alpha. Acta Crystallogr.,Sect.F, 78, 2022
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7U4S
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![BU of 7u4s by Molmil](/molmil-images/mine/7u4s) | Structure of Glyceraldehyde-3-Phosphate Dehydrogenase from Candida albicans | Descriptor: | GLYCEROL, Glyceraldehyde-3-phosphate dehydrogenase | Authors: | Miranda, R.R, Silva, M, Iulek, J. | Deposit date: | 2022-02-28 | Release date: | 2022-04-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Expression, purification, crystallization and structure of Glyceraldehyde-3-Phosphate Dehydrogenase from Candida albicans, main causative agent of candidiasis Chem. Data Coll., 39, 2022
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7X38
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![BU of 7x38 by Molmil](/molmil-images/mine/7x38) | Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 8A10 (CVB1-E:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X3F
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![BU of 7x3f by Molmil](/molmil-images/mine/7x3f) | Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 9A3 (CVB1-A:9A3) | Descriptor: | 9A3 heavy chain, 9A3 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X37
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![BU of 7x37 by Molmil](/molmil-images/mine/7x37) | Cryo-EM structure of Coxsackievirus B1 A particle in complex with nAb 2E6 (CVB1-A:2E6) | Descriptor: | 2E6 heavy chain, 2E6 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X3E
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![BU of 7x3e by Molmil](/molmil-images/mine/7x3e) | Cryo-EM structure of Coxsackievirus B1 pre-A-particle in complex with nAb 9A3 (CVB1-pre-A:9A3) | Descriptor: | 9A3 heavy chain, 9A3 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X3D
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![BU of 7x3d by Molmil](/molmil-images/mine/7x3d) | Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 9A3 (CVB1-M:9A3) | Descriptor: | 9A3 heavy chain, 9A3 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X3C
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![BU of 7x3c by Molmil](/molmil-images/mine/7x3c) | Cryo-EM structure of Coxsackievirus B1 muture virion in complex with nAbs 8A10 and 5F5 (CVB1-M:8A10:5F5) | Descriptor: | 5F5 heavy chain, 5F5 light chain, 8A10 heavy chain, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7U4E
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![BU of 7u4e by Molmil](/molmil-images/mine/7u4e) | |
7U4F
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![BU of 7u4f by Molmil](/molmil-images/mine/7u4f) | |
7X35
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![BU of 7x35 by Molmil](/molmil-images/mine/7x35) | Cryo-EM structure of Coxsackievirus B1 A-particle in complex with nAb 8A10 (CVB1-A:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, VP2, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-28 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7U4G
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![BU of 7u4g by Molmil](/molmil-images/mine/7u4g) | Neuraminidase from influenza virus A/Shandong/9/1993(H3N2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neuraminidase, ... | Authors: | Lei, R, Hernandez Garcia, A. | Deposit date: | 2022-02-28 | Release date: | 2022-10-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase. Nat Commun, 13, 2022
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7Z2P
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![BU of 7z2p by Molmil](/molmil-images/mine/7z2p) | Tubulin-nocodazole complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Prota, A.E, Muehlethaler, T, Cavalli, A, Steinmetz, M.O. | Deposit date: | 2022-02-28 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. Eur.J.Med.Chem., 241, 2022
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7Z2N
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![BU of 7z2n by Molmil](/molmil-images/mine/7z2n) | Tubulin-18-complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Muehlethaler, T, Prota, A.E, Cavalli, A, Steinmetz, M.O. | Deposit date: | 2022-02-28 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents. Eur.J.Med.Chem., 241, 2022
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7Z2R
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![BU of 7z2r by Molmil](/molmil-images/mine/7z2r) | Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics | Descriptor: | Glutamate receptor ionotropic, delta-1, SULFATE ION | Authors: | Masternak, M, Laulumaa, S, Kastrup, J.S. | Deposit date: | 2022-02-28 | Release date: | 2023-01-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.574 Å) | Cite: | Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics. Febs J., 290, 2023
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7Z2I
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![BU of 7z2i by Molmil](/molmil-images/mine/7z2i) | TRYPSIN (BOVINE) COMPLEXED WITH compound 4 | Descriptor: | 5-[[3-(trifluoromethyl)phenyl]methyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine, CALCIUM ION, DIMETHYL SULFOXIDE, ... | Authors: | Schiering, N, Dalvit, C, Vulpetti, A. | Deposit date: | 2022-02-27 | Release date: | 2022-05-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts. Chemmedchem, 17, 2022
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7Z2H
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![BU of 7z2h by Molmil](/molmil-images/mine/7z2h) | Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine | Descriptor: | 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile, DNA (38-MER), Reverse transcriptase/ribonuclease H, ... | Authors: | Singh, A.K, Das, K. | Deposit date: | 2022-02-27 | Release date: | 2022-07-20 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X2U
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![BU of 7x2u by Molmil](/molmil-images/mine/7x2u) | Structure of a human NHE3-CHP1 complex in the autoinhibited state | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Calcineurin B homologous protein 1, Sodium/hydrogen exchanger 3, ... | Authors: | Dong, Y, Li, H, Gao, Y, Zhang, X.C, Zhao, Y. | Deposit date: | 2022-02-26 | Release date: | 2022-04-20 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a human NHE3-CHP1 complex in the autoinhibited state Sci Adv, 2022
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7X2R
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![BU of 7x2r by Molmil](/molmil-images/mine/7x2r) | |
7X2W
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![BU of 7x2w by Molmil](/molmil-images/mine/7x2w) | Cryo-EM structure of Coxsackievirus B1 pre-A particle in complex with nAb 8A10 (CVB1-pre-A:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X2T
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![BU of 7x2t by Molmil](/molmil-images/mine/7x2t) | Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (CVB1-M:8A10) | Descriptor: | 8A10 heavy chain, 8A10 light chain, Capsid protein VP4, ... | Authors: | Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N. | Deposit date: | 2022-02-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe, 30, 2022
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7X2V
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![BU of 7x2v by Molmil](/molmil-images/mine/7x2v) | GPR110/Gi complex | Descriptor: | Adhesion G-protein coupled receptor F1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | He, Y, Zhu, X. | Deposit date: | 2022-02-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun, 13, 2022
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7X2Q
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![BU of 7x2q by Molmil](/molmil-images/mine/7x2q) | Salvia miltiorrhiza CYP76AH3 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Sugiol synthase | Authors: | Chang, Z. | Deposit date: | 2022-02-26 | Release date: | 2023-03-01 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.68 Å) | Cite: | Structure of CYP76AH3 at 3.67 Angstroms resolution To Be Published
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7Z2G
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![BU of 7z2g by Molmil](/molmil-images/mine/7z2g) | Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine | Descriptor: | 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile, DNA (38-MER), Reverse transcriptase/ribonuclease H | Authors: | Singh, A.K, Das, K. | Deposit date: | 2022-02-26 | Release date: | 2022-07-20 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proc.Natl.Acad.Sci.USA, 119, 2022
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