4KFC
 
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4JAS
 | | Structural basis of a rationally rewired protein-protein interface (HK853mutant A268V, A271G, T275M, V294T and D297E and RR468mutant V13P, L14I, I17M and N21V) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Histidine kinase, MAGNESIUM ION, ... | | Authors: | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | | Deposit date: | 2013-02-19 | | Release date: | 2013-09-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling
Structure, 21, 2013
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4JAV
 | | Structural basis of a rationally rewired protein-protein interface (HK853wt and RR468mutant V13P, L14I, I17M and N21V) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Histidine kinase, ... | | Authors: | Podgornaia, A.I, Casino, P, Marina, A, Laub, M.T. | | Deposit date: | 2013-02-19 | | Release date: | 2013-09-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling
Structure, 21, 2013
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2FTK
 | | berylloflouride Spo0F complex with Spo0B | | Descriptor: | MAGNESIUM ION, Sporulation initiation phosphotransferase B, Sporulation initiation phosphotransferase F | | Authors: | Varughese, K.I. | | Deposit date: | 2006-01-24 | | Release date: | 2006-07-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | The Crystal Structure of Beryllofluoride Spo0F in Complex with the Phosphotransferase Spo0B Represents a Phosphotransfer Pretransition State.
J.Bacteriol., 188, 2006
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4KNY
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2GWR
 | | Crystal structure of the response regulator protein mtrA from Mycobacterium Tuberculosis | | Descriptor: | CALCIUM ION, DNA-binding response regulator mtrA, GLYCEROL | | Authors: | Friedland, N, Mack, T.R, Yu, M, Bursey, E.H, Hung, L.W, Stock, A.M, Waldo, G.S, Terwilliger, T.C. | | Deposit date: | 2006-05-05 | | Release date: | 2006-05-23 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation.
Biochemistry, 46, 2007
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4L4U
 | | Crystal structure of construct containing A. aeolicus NtrC1 receiver, central and DNA binding domains | | Descriptor: | Transcriptional regulator (NtrC family) | | Authors: | Vidangos, N.K, Maris, A.E, Young, A, Hong, E, Pelton, J.G, Batchelor, J.D, Wemmer, D.E. | | Deposit date: | 2013-06-09 | | Release date: | 2013-08-28 | | Last modified: | 2013-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure, function, and tethering of DNA-binding domains in sigma (54) transcriptional activators.
Biopolymers, 99, 2013
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2R25
 | | Complex of YPD1 and SLN1-R1 with bound Mg2+ and BeF3- | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Osmosensing histidine protein kinase SLN1, ... | | Authors: | Copeland, D.M, Zhao, X, Soares, A.S, West, A.H. | | Deposit date: | 2007-08-24 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of a complex between the phosphorelay protein YPD1 and
the response regulator domain of SLN1 bound to a phosphoryl analog
J.Mol.Biol., 375, 2008
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4LDZ
 | | Crystal structure of the full-length response regulator DesR in the active state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Trajtenberg, F, Larrieux, N, Buschiazzo, A. | | Deposit date: | 2013-06-25 | | Release date: | 2014-07-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation.
MBio, 5, 2014
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2V0N
 | | ACTIVATED RESPONSE REGULATOR PLED IN COMPLEX WITH C-DIGMP AND GTP- ALPHA-S | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), BERYLLIUM TRIFLUORIDE ION, CHLORIDE ION, ... | | Authors: | Wassmann, P, Schirmer, T. | | Deposit date: | 2007-05-15 | | Release date: | 2007-08-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Structure of Bef3--Modified Response Regulator Pled: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition
Structure, 15, 2007
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2HQR
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2LP4
 | | Solution structure of P1-CheY/P2 complex in bacterial chemotaxis | | Descriptor: | Chemotaxis protein CheA, Chemotaxis protein CheY | | Authors: | Dahlquist, F, Mo, G, Zhou, H, Kamamura, T. | | Deposit date: | 2012-01-31 | | Release date: | 2012-10-24 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a complex of the histidine autokinase CheA with its substrate CheY.
Biochemistry, 51, 2012
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3I5A
 | | Crystal structure of full-length WpsR from Pseudomonas syringae | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Response regulator/GGDEF domain protein, STRONTIUM ION | | Authors: | Navarro, M.V.A.S, De, N, Sondermann, H. | | Deposit date: | 2009-07-03 | | Release date: | 2009-08-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.796 Å) | | Cite: | Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR.
J.Mol.Biol., 393, 2009
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3HZH
 | | Crystal structure of the CheX-CheY-BeF3-Mg+2 complex from Borrelia burgdorferi | | Descriptor: | Chemotaxis operon protein (CheX), Chemotaxis response regulator (CheY-3), MAGNESIUM ION | | Authors: | Pazy, Y, Silversmith, R.E, Guarinari, M, Zhao, R. | | Deposit date: | 2009-06-23 | | Release date: | 2010-02-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2LLE
 | | Computational design of an eight-stranded (beta/alpha)-barrel from fragments of different folds | | Descriptor: | Chemotaxis protein CheY, Imidazole glycerol phosphate synthase subunit HisF chimera | | Authors: | Coles, M, Truffault, V, Eisenbeis, S, Proffitt, W, Meiler, J, Hocker, B. | | Deposit date: | 2011-11-07 | | Release date: | 2012-03-21 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Potential of fragment recombination for rational design of proteins.
J.Am.Chem.Soc., 134, 2012
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3KYJ
 | | Crystal structure of the P1 domain of CheA3 in complex with CheY6 from R. sphaeroides | | Descriptor: | CheY6 protein, Putative histidine protein kinase, SODIUM ION | | Authors: | Bell, C.H, Porter, S.L, Armitage, J.P, Stuart, D.I. | | Deposit date: | 2009-12-06 | | Release date: | 2010-02-16 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex
Plos Biol., 8, 2010
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3M6M
 | | Crystal structure of RpfF complexed with REC domain of RpfC | | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Cheng, Z, Lim, S.C, Qamra, R, Song, H. | | Deposit date: | 2010-03-16 | | Release date: | 2010-09-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis of the Sensor-Synthase Interaction in Autoinduction of the Quorum Sensing Signal DSF Biosynthesis
Structure, 18, 2010
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3KYI
 | | Crystal structure of the phosphorylated P1 domain of CheA3 in complex with CheY6 from R. sphaeroides | | Descriptor: | CheY6 protein, Putative histidine protein kinase | | Authors: | Bell, C.H, Porter, S.L, Armitage, J.P, Stuart, D.I. | | Deposit date: | 2009-12-06 | | Release date: | 2010-02-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex
Plos Biol., 8, 2010
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3C3W
 | | Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR | | Descriptor: | SULFATE ION, TWO COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR | | Authors: | Wisedchaisri, G, Wu, M, Sherman, D.R, Hol, W.G.J. | | Deposit date: | 2008-01-28 | | Release date: | 2008-04-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation
J.Mol.Biol., 378, 2008
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3DGE
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3DZD
 | | Crystal structure of sigma54 activator NTRC4 in the inactive state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SODIUM ION, Transcriptional regulator (NtrC family) | | Authors: | Batchelor, J.D, Doucleff, M, Lee, C.-J, Matsubara, K, De Carlo, S, Heideker, J, Lamers, M.M, Pelton, J.G, Wemmer, D.E. | | Deposit date: | 2008-07-29 | | Release date: | 2008-11-25 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure and regulatory mechanism of Aquifex aeolicus NtrC4: variability and evolution in bacterial transcriptional regulation.
J.Mol.Biol., 384, 2008
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3BRE
 | | Crystal Structure of P.aeruginosa PA3702 | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, Probable two-component response regulator | | Authors: | De, N, Pirruccello, M, Krasteva, P.V, Bae, N, Raghavan, R.V, Sondermann, H. | | Deposit date: | 2007-12-21 | | Release date: | 2008-04-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Phosphorylation-independent regulation of the diguanylate cyclase WspR.
Plos Biol., 6, 2008
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3EQ2
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3Q15
 | | Crystal Structure of RapH complexed with Spo0F | | Descriptor: | GLYCEROL, MAGNESIUM ION, Response regulator aspartate phosphatase H, ... | | Authors: | Parashar, V, Neiditch, M.B. | | Deposit date: | 2010-12-16 | | Release date: | 2011-02-23 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.192 Å) | | Cite: | Structural basis of response regulator dephosphorylation by Rap phosphatases.
Plos Biol., 9, 2011
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3R0J
 | | Structure of PhoP from Mycobacterium tuberculosis | | Descriptor: | POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP, R-1,2-PROPANEDIOL, SULFATE ION | | Authors: | Menon, S, Wang, S. | | Deposit date: | 2011-03-08 | | Release date: | 2011-07-13 | | Last modified: | 2014-10-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain.
Biochemistry, 50, 2011
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