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8E14	Cryo-EM structure of Rous sarcoma virus strand transfer complex Descriptor: DNA (42-MER), DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*TP*AP*CP*TP*C)-3'), DNA (5'-D(*AP*GP*TP*GP*TP*CP*TP*TP*CP*TP*TP*CP*TP*TP*TP*C)-3'), ... Authors: Pandey, K.K, Bera, S, Shi, K, Aihara, H, Grandgenett, D.P. Deposit date: 2022-08-09 Release date: 2023-04-26 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: Molecular determinants for Rous sarcoma virus intasome assemblies involved in retroviral integration. J.Biol.Chem., 299, 2023
8FN7	Structure of WT HIV-1 intasome bound to Dolutegravir Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FND	Structure of E138K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (3 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNG	Structure of E138K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNH	Structure of Q148K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNJ	Structure of E138K/G140A HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNL	Structure of E138K/Q148K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNM	Structure of G140A/Q148K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNN	Structure of E138K/G140A/Q148K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNO	Structure of E138K/G140A/Q148R HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-28 Release date: 2023-08-09 Last modified: 2023-09-20 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNP	Structure of E138K/G140S/Q148H HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-28 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8FNQ	Structure of E138K/G140A/Q148K HIV-1 intasome with 4d bound Descriptor: 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-28 Release date: 2023-08-09 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023
8S9Q	HIV-1 Integrase Catalytic Core Domain (CCD) F185H Mutant Complexed with STP03-0404 Descriptor: (2S)-tert-butoxy{4-(4-chlorophenyl)-2,3,6-trimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid, Integrase Authors: Dinh, T, Kvaratskhelia, M. Deposit date: 2023-03-29 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.26 Å) Cite: HIV-1 Integrase Catalytic Core Domain Complexed with STP-0404 To Be Published
8W09	HIV-1 wild-type intasome core Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ... Authors: Li, M, Craigie, R. Deposit date: 2024-02-13 Release date: 2024-04-17 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
8W2R	HIV-1 P5-IN intasome core Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... Authors: Li, M, Craigie, R. Deposit date: 2024-02-21 Release date: 2024-04-17 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
8W34	HIV-1 intasome core assembled with wild-type integrase, 1F Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... Authors: Li, M, Craigie, R. Deposit date: 2024-02-21 Release date: 2024-04-17 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
8WF7	The Crystal Structure of integrase from Biortus Descriptor: ACETATE ION, Integrase, SULFATE ION Authors: Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. Deposit date: 2023-09-19 Release date: 2023-10-04 Method: X-RAY DIFFRACTION (1.55 Å) Cite: The Crystal Structure of integrase from Biortus To Be Published

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