PDB: 8717 resultsInfo pagesStatus searchChemie searchBIRD

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8BZY	Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation Descriptor: 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, DIUNDECYL PHOSPHATIDYL CHOLINE, Solute carrier family 40 member 1, ... Authors: Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. Deposit date: 2022-12-15 Release date: 2023-03-22 Last modified: 2023-05-24 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
8C02	Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation Descriptor: Solute carrier family 40 member 1, Sybody3 Authors: Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. Deposit date: 2022-12-15 Release date: 2023-03-22 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (4.09 Å) Cite: Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
3HA8	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/Compound 14b Descriptor: Mitogen-activated protein kinase 14, N~2~-{4-[6-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)-1H-benzimidazol-1-yl]-6-ethoxy-1,3,5-triazin-2-yl}-3-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-N-methyl-L-alaninamide Authors: Zhao, B, Clark, M.A. Deposit date: 2009-05-01 Release date: 2009-08-04 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat.Chem.Biol., 5, 2009
4QJD	Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution Descriptor: MAGNESIUM ION, Twister RNA sequence Authors: Eiler, D.R, Wang, J, Steitz, T.A. Deposit date: 2014-06-03 Release date: 2014-09-03 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme. Proc.Natl.Acad.Sci.USA, 111, 2014
3VKX	Structure of PCNA Descriptor: 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ... Authors: Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N. Deposit date: 2011-11-26 Release date: 2012-03-14 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication J.Biol.Chem., 287, 2012
3WU1	Crystal structure of the ETS1-RUNX1-DNA ternary complex Descriptor: DNA (5'-D(*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), Protein C-ets-1, ... Authors: Tahirov, T.H, Ogata, K. Deposit date: 2014-04-21 Release date: 2014-08-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions. J.Mol.Biol., 427, 2015
5HRF	The crystal structure of AsfvPolX: DNA5: dGTP ternary complex Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*GP*AP*TP*CP*CP*T*)-3'), DNA polymerase beta-like protein, ... Authors: Chen, Y.Q, Zhang, J, Gan, J.H. Deposit date: 2016-01-23 Release date: 2017-01-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published
3HL7	Crystal Structure of Human p38alpha complexed with SD-0006 Descriptor: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol, Mitogen-activated protein kinase 14 Authors: Shieh, H.-S, Kurumbail, R.G, Stegeman, R.A, Williams, J.M. Deposit date: 2009-05-26 Release date: 2009-07-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009
3HLL	Crystal Structure of Human p38alpha complexed with PH-797804 Descriptor: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide, HYPOPHOSPHITE, ... Authors: Shieh, H.-S, Williams, J.M, Stegeman, R.A, Kurumbail, R.G. Deposit date: 2009-05-27 Release date: 2009-07-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009
5HRL	The crystal structure of AsfvPolX: 1nt-gap(P) DNA2: dGTP ternary complex. Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*TP*CP*TP*AP*TP*GP*TP*GP*TP*AP*CP*TP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*A)-3'), ... Authors: Chen, Y.Q, Zhang, J, Gan, J.H. Deposit date: 2016-01-23 Release date: 2017-01-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published
3FQI	Crystal Structure of the Mouse Dom3Z Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, Protein Dom3Z Authors: Xiang, S, Tong, L. Deposit date: 2009-01-07 Release date: 2009-02-03 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.013 Å) Cite: Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
3FQJ	Crystal Structure of the Mouse Dom3Z in Complex with GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein Dom3Z Authors: Xiang, S, Tong, L. Deposit date: 2009-01-07 Release date: 2009-02-03 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.623 Å) Cite: Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 2009
5HRH	The crystal structure of AsfvPolX(H115F/R127A mutant): 1nt-gap(P) DNA2:dGTP ternary complex Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*TP*CP*TP*AP*TP*GP*TP*GP*TP*AP*CP*TP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*A*)-3'), ... Authors: Chen, Y.Q, Zhang, J, Gan, J.H. Deposit date: 2016-01-23 Release date: 2017-01-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published
6BCB	A Complex between PH Domain of p114RhoGEF and Activated RhoA Bound to a GTP Analog Descriptor: 1,2-ETHANEDIOL, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... Authors: Sternweis, P.C, Chen, Z. Deposit date: 2017-10-20 Release date: 2017-12-13 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.401 Å) Cite: Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. Data Brief, 17, 2018
5HRK	The crystal structure of AsfvPolX(H115F mutant): 1nt-gap(P) DNA2:dGTP ternary complex Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*TP*CP*TP*AP*TP*GP*TP*GP*TP*AP*CP*TP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*AP*GP*TP*AP*CP*A)-3'), ... Authors: Chen, Y.Q, Zhang, J, Gan, J.H. Deposit date: 2016-01-23 Release date: 2017-01-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The crystal structure of Se-AsfvPolX(L52/163M mutant) in complex with 1nt-gap DNA1 To Be Published
6RLW	Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487 Descriptor: 4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide, N-glycosylase/DNA lyase Authors: Masuyer, G, Stenmark, P. Deposit date: 2019-05-03 Release date: 2020-07-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Res., 48, 2020
6BCA	A Complex between PH Domain of LbcRhoGEF (AKAP-Lbc) and Activated RhoA Bound to a GTP Analog Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, A-kinase anchor protein 13, MAGNESIUM ION, ... Authors: Sternweis, P.C, Chen, Z. Deposit date: 2017-10-20 Release date: 2017-12-13 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.995 Å) Cite: Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase. Data Brief, 17, 2018
3HEC	P38 in complex with Imatinib Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Namboodiri, H.V, Karpusas, M. Deposit date: 2009-05-08 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49, 2010
3HEG	P38 in complex with Sorafenib Descriptor: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Mitogen-activated protein kinase 14 Authors: Namboodiri, H.V, Karpusas, M. Deposit date: 2009-05-08 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49, 2010
3UIN	Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 Descriptor: E3 SUMO-protein ligase RanBP2, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ... Authors: Gareau, J.R, Reverter, D, Lima, C.D. Deposit date: 2011-11-05 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.597 Å) Cite: Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. J.Biol.Chem., 287, 2012
2Z9G	Complex structure of SARS-CoV 3C-like protease with PMA Descriptor: 3C-like proteinase, BENZENE, MERCURY (II) ION Authors: Lee, C.C, Wang, A.H. Deposit date: 2007-09-19 Release date: 2007-12-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors. Febs Lett., 581, 2007
8PK5	INTS13-INTS14 complex with ZNF609 Descriptor: Integrator complex subunit 13, Integrator complex subunit 14,Zinc finger protein 609, MAGNESIUM ION Authors: Sabath, K, Jonas, S. Deposit date: 2023-06-25 Release date: 2024-07-03 Last modified: 2024-07-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Basis of gene-specific transcription regulation by the Integrator complex. Mol.Cell, 84, 2024
4DTX	RB69 DNA Polymerase Ternary Complex with dTTP Opposite an Abasic Site and ddC/dG as the Penultimate Base-pair Descriptor: CALCIUM ION, DNA polymerase, DNA primer, ... Authors: Xia, S, Wang, J, Konigsberg, W.H. Deposit date: 2012-02-21 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA. Biochemistry, 51, 2012
1GOL	COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION Authors: Harkins, P.C, Zhang, F, Goldsmith, E.J. Deposit date: 1996-01-23 Release date: 1997-03-12 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. Biochemistry, 35, 1996
8BI7	Binary structure of 14-3-3s and PKR phosphopeptide Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, PKR phosphopeptide Authors: Somsen, B.A, Ottmann, C. Deposit date: 2022-11-01 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR gamma Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J.Am.Chem.Soc., 145, 2023

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