PDB: 41454 resultsInfo pagesStatus searchChemie searchBIRD

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6RM5	Fragment AZ-016 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 7-(6-azanyl-5-methyl-pyridin-2-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-05-05 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.884 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6S3C	Fragment AZ-019 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. Deposit date: 2019-06-25 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SIN	Fragment AZ-020 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, Cellular tumor antigen p53, ~{N}-[2-(5-carbamimidoylthiophen-3-yl)phenyl]prop-2-enamide Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-08-10 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SIP	Fragment AZ-011 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 7-methoxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Leysen, S, Wolter, M, Guillory, X, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-08-10 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.600447 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SIQ	Fragment AZ-012 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-chloranyl-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Leysen, S, Wolter, M, Guillory, X, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-08-10 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.60121 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SLV	Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-(methylamino)-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. Deposit date: 2019-08-20 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SLX	Fragment AZ-010 binding at the TAZpS89/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, TAZpS89, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]propanamide Authors: Ottmann, C, Wolter, M, Guillory, X, Genet, S, Somsen, B, Leysen, S, Castaldi, P. Deposit date: 2019-08-20 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.800045 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SLW	Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 Authors: Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. Deposit date: 2019-08-20 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6GE6	X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface Descriptor: MYRISTIC ACID, PHOSPHATE ION, Transcriptional coactivator YAP1, ... Authors: Kallen, J. Deposit date: 2018-04-25 Release date: 2018-09-19 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
6RWI	Fragment AZ-002 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 5-phenylthiophene-2-carboximidamide, CALCIUM ION, ... Authors: Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-06-05 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RWS	Fragment AZ-009 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-chloranyl-6-(sulfanylmethyl)-1-benzothiophene-2-carboximidamide, Cellular tumor antigen p53, ... Authors: Leysen, S, Guillory, X, Wolter, M, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-06-06 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RKI	Fragment AZ-023 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 5-[(3-aminophenyl)amino]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. Deposit date: 2019-04-30 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RKM	Fragment AZ-022 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-phenyl-5-phenylazanyl-thiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-04-30 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RL4	Fragment AZ-025 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-05-01 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RP6	Fragment AZ-019 binding at the TAZpS89/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CALCIUM ION, ... Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-05-14 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.885 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6SIO	Fragment AZ-017 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 5-methyl-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Leysen, S, Wolter, M, Guillory, X, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-08-10 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.60418 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RJL	Fragment AZ-018 binding at the TAZpS89/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide, TAZpS89 Authors: Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-04-27 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6RM7	Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... Authors: Somsen, B, Wolter, M, Guillory, X, Genet, S, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. Deposit date: 2019-05-05 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
6GE3	X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility and water molecules in the adaptation of a bound intrinsically disordered protein to mutations at a binding interface Descriptor: GLYCEROL, MYRISTIC ACID, Transcriptional coactivator YAP1, ... Authors: Kallen, J. Deposit date: 2018-04-25 Release date: 2018-09-19 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Adaptation of the bound intrinsically disordered protein YAP to mutations at the YAP:TEAD interface. Protein Sci., 27, 2018
7KHD	Human GITR-GITRL complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 Authors: Wang, F, Chau, B, West, S.M, Strop, P. Deposit date: 2020-10-21 Release date: 2021-03-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.956102 Å) Cite: Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
7KHX	Mouse GITR-GITRL complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ... Authors: Wang, F, Chau, B, West, S.M, Strop, P. Deposit date: 2020-10-22 Release date: 2021-03-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.20569849 Å) Cite: Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
6CFZ	Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface Descriptor: Ask1, Dad1,Dad1, Dad2, ... Authors: Jenni, S, Harrison, S.C. Deposit date: 2018-02-19 Release date: 2018-05-02 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface. Science, 360, 2018
1B27	STRUCTURAL RESPONSE TO MUTATION AT A PROTEIN-PROTEIN INTERFACE Descriptor: PROTEIN (BARNASE), PROTEIN (BARSTAR) Authors: Vaughan, C.K, Buckle, A.M, Fersht, A.R. Deposit date: 1998-12-04 Release date: 1998-12-09 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural response to mutation at a protein-protein interface. J.Mol.Biol., 286, 1999
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016

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