2C6L
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![BU of 2c6l by Molmil](/molmil-images/mine/2c6l) | Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | Descriptor: | 4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 | Authors: | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | Deposit date: | 2005-11-10 | Release date: | 2005-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
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2C6M
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![BU of 2c6m by Molmil](/molmil-images/mine/2c6m) | Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | Descriptor: | 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 | Authors: | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | Deposit date: | 2005-11-10 | Release date: | 2005-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
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2C6N
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![BU of 2c6n by Molmil](/molmil-images/mine/2c6n) | Structure of human somatic angiontensin-I converting enzyme N domain with lisinopril | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Corradi, H.R, Schwager, S.L.U, Nichinda, A, Sturrock, E.D, Acharya, K.R. | Deposit date: | 2005-11-10 | Release date: | 2006-03-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. J. Mol. Biol., 357, 2006
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2C6O
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![BU of 2c6o by Molmil](/molmil-images/mine/2c6o) | Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | Descriptor: | CELL DIVISION PROTEIN KINASE 2, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE | Authors: | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | Deposit date: | 2005-11-10 | Release date: | 2005-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg. Med. Chem. Lett., 16, 2006
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2C6P
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![BU of 2c6p by Molmil](/molmil-images/mine/2c6p) | Membrane-bound glutamate carboxypeptidase II (GCPII) in complex with phosphate anion | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Mesters, J.R, Barinka, C, Li, W, Tsukamoto, T, Majer, P, Slusher, B.S, Konvalinka, J, Hilgenfeld, R. | Deposit date: | 2005-11-11 | Release date: | 2006-02-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structure of Glutamate Carboxypeptidase II, a Drug Target in Neuronal Damage and Prostate Cancer. Embo J., 25, 2006
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2C6Q
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![BU of 2c6q by Molmil](/molmil-images/mine/2c6q) | Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP and NADPH | Descriptor: | GMP REDUCTASE 2, INOSINIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Kursula, P, Stenmark, P, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Graslund, S, Hammarstrom, M, Hallberg, B.M, Kotenyova, T, Nilsson-Ehle, P, Ogg, D, Persson, C, Sagemark, J, Schuler, H, Sundstrom, M, Thorsell, A, Weigelt, J, Nordlund, P. | Deposit date: | 2005-11-11 | Release date: | 2005-11-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes. Nat.Chem.Biol., 7, 2011
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2C6R
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![BU of 2c6r by Molmil](/molmil-images/mine/2c6r) | FE-SOAKED CRYSTAL STRUCTURE OF THE DPS92 FROM DEINOCOCCUS RADIODURANS | Descriptor: | CHLORIDE ION, DNA-BINDING STRESS RESPONSE PROTEIN, DPS FAMILY, ... | Authors: | Cuypers, M.G, Romao, C.V, Mitchell, E, Mcsweeney, S. | Deposit date: | 2005-11-11 | Release date: | 2007-02-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Crystal Structure of the Dps2 from Deinococcus Radiodurans Reveals an Unusual Pore Profile with a Non-Specific Metal Binding Site. J.Mol.Biol., 371, 2007
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2C6S
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![BU of 2c6s by Molmil](/molmil-images/mine/2c6s) | |
2C6T
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![BU of 2c6t by Molmil](/molmil-images/mine/2c6t) | Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | Descriptor: | 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 | Authors: | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | Deposit date: | 2005-11-11 | Release date: | 2005-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
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2C6U
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![BU of 2c6u by Molmil](/molmil-images/mine/2c6u) | |
2C6W
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![BU of 2c6w by Molmil](/molmil-images/mine/2c6w) | PENICILLIN-BINDING PROTEIN 1A (PBP-1A) FROM STREPTOCOCCUS PNEUMONIAE | Descriptor: | CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1A, ZINC ION | Authors: | Contreras-Martel, C, Job, V, Di Guilmi, A.-M, Vernet, T, Dideberg, O, Dessen, A. | Deposit date: | 2005-11-14 | Release date: | 2005-12-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Crystal Structure of Penicillin-Binding Protein 1A (Pbp1A) Reveals a Mutational Hotspot Implicated in Beta-Lactam Resistance in Streptococcus Pneumoniae. J.Mol.Biol., 355, 2006
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2C6X
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![BU of 2c6x by Molmil](/molmil-images/mine/2c6x) | |
2C6Y
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![BU of 2c6y by Molmil](/molmil-images/mine/2c6y) | Crystal structure of interleukin enhancer-binding factor 1 bound to DNA | Descriptor: | FORKHEAD BOX PROTEIN K2, INTERLEUKIN 2 PROMOTOR, MAGNESIUM ION | Authors: | Tsai, K.-L, Huang, C.-Y, Chang, C.-H, Sun, Y.-J, Chuang, W.-J, Hsiao, C.-D. | Deposit date: | 2005-11-15 | Release date: | 2006-04-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Human Foxk1A-DNA Complex and its Implications on the Diverse Binding Specificity of Winged Helix/Forkhead Proteins. J.Biol.Chem., 281, 2006
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2C6Z
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![BU of 2c6z by Molmil](/molmil-images/mine/2c6z) | crystal structure of dimethylarginine dimethylaminohydrolase I in complex with citrulline | Descriptor: | CITRIC ACID, CITRULLINE, NG, ... | Authors: | Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. | Deposit date: | 2005-11-16 | Release date: | 2006-05-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inbitors Structure, 14, 2006
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2C70
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![BU of 2c70 by Molmil](/molmil-images/mine/2c70) | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins | Descriptor: | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, P-NITRO-BENZYLAMINE | Authors: | Li, M, Binda, C, Mattevi, A, Edmondson, D.E. | Deposit date: | 2005-11-17 | Release date: | 2006-04-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins Biochemistry, 45, 2006
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2C71
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![BU of 2c71 by Molmil](/molmil-images/mine/2c71) | The structure of a family 4 acetyl xylan esterase from Clostridium thermocellum in complex with a magnesium ion. | Descriptor: | GLYCOSIDE HYDROLASE, FAMILY 11:CLOSTRIDIUM CELLULOSOME ENZYME, DOCKERIN TYPE I:POLYSACCHARIDE, ... | Authors: | Taylor, E.J, Turkenburg, P.J, Vincent, F, Brzozowski, A.M, Gloster, T.M, Dupont, C, Shareck, F, Centeno, M.S.J, Prates, J.A.M, Ferreira, L.M.A, Fontes, C.M.G.A, Biely, P, Davies, G.J. | Deposit date: | 2005-11-17 | Release date: | 2006-01-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structure and Activity of Two Metal-Ion Dependent Acetyl Xylan Esterases Involved in Plant Cell-Wall Degradation Reveals a Close Similarity to Peptidoglycan Deacetylases. J.Biol.Chem., 281, 2006
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2C72
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![BU of 2c72 by Molmil](/molmil-images/mine/2c72) | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins | Descriptor: | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN | Authors: | Li, M, Binda, C, Mattevi, A, Edmondson, D.E. | Deposit date: | 2005-11-17 | Release date: | 2006-04-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins Biochemistry, 45, 2006
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2C73
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![BU of 2c73 by Molmil](/molmil-images/mine/2c73) | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins | Descriptor: | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN | Authors: | Li, M, Binda, C, Mattevi, A, Edmondson, D.E. | Deposit date: | 2005-11-17 | Release date: | 2006-04-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins Biochemistry, 45, 2006
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2C74
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![BU of 2c74 by Molmil](/molmil-images/mine/2c74) | 14-3-3 Protein Eta (Human) Complexed to Peptide | Descriptor: | 14-3-3 PROTEIN ETA, CITRIC ACID, CONSENSUS PEPTIDE MODE 1 FOR 14-3-3 PROTEINS | Authors: | Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A. | Deposit date: | 2005-11-17 | Release date: | 2005-12-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
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2C75
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![BU of 2c75 by Molmil](/molmil-images/mine/2c75) | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins | Descriptor: | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN | Authors: | Li, M, Binda, C, Mattevi, A, Edmondson, D.E. | Deposit date: | 2005-11-17 | Release date: | 2006-04-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins Biochemistry, 45, 2006
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2C76
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![BU of 2c76 by Molmil](/molmil-images/mine/2c76) | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins | Descriptor: | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN | Authors: | Li, M, Binda, C, Mattevi, A, Edmondson, D.E. | Deposit date: | 2005-11-17 | Release date: | 2006-04-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins Biochemistry, 45, 2006
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2C77
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![BU of 2c77 by Molmil](/molmil-images/mine/2c77) | EF-Tu complexed with a GTP analog and the antibiotic GE2270 A | Descriptor: | DI(HYDROXYETHYL)ETHER, ELONGATION FACTOR TU-B, MAGNESIUM ION, ... | Authors: | Parmeggiani, A, Krab, I.M, Okamura, S, Nielsen, R.C, Nyborg, J, Nissen, P. | Deposit date: | 2005-11-18 | Release date: | 2006-03-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu. Biochemistry, 45, 2006
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2C78
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![BU of 2c78 by Molmil](/molmil-images/mine/2c78) | EF-Tu complexed with a GTP analog and the antibiotic pulvomycin | Descriptor: | (1S,2S,3E,5E,7E,10S,11S,12S)-12-[(2R,4E,6E,8Z,10R,12E,14E,16Z,18S,19Z)-10,18-DIHYDROXY-12,16,19-TRIMETHYL-11,22-DIOXOOX ACYCLODOCOSA-4,6,8,12,14,16,19-HEPTAEN-2-YL]-2,11-DIHYDROXY-1,10-DIMETHYL-9-OXOTRIDECA-3,5,7-TRIEN-1-YL 6-DEOXY-2,4-DI-O-METHYL-BETA-L-GALACTOPYRANOSIDE, ELONGATION FACTOR TU-A, MAGNESIUM ION, ... | Authors: | Parmeggiani, A, Krab, I.M, Okamura, S, Nielsen, R.C, Nyborg, J, Nissen, P. | Deposit date: | 2005-11-18 | Release date: | 2006-03-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu. Biochemistry, 45, 2006
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2C79
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![BU of 2c79 by Molmil](/molmil-images/mine/2c79) | The structure of a family 4 acetyl xylan esterase from Clostridium thermocellum in complex with a colbalt ion. | Descriptor: | COBALT (II) ION, GLYCOSIDE HYDROLASE, FAMILY 11:CLOSTRIDIUM CELLULOSOME ENZYME, ... | Authors: | Taylor, E.J, Turkenburg, P.J, Vincent, F, Brzozowski, A.M, Gloster, T.M, Dupont, C, Shareck, F, Centeno, M.S.J, Prates, J.A.M, Ferreira, L.M.A, Fontes, C.M.G.A, Biely, P, Davies, G.J. | Deposit date: | 2005-11-18 | Release date: | 2006-01-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure and Activity of Two Metal-Ion Dependent Acetyl Xylan Esterases Involved in Plant Cell Wall Degradation Reveals a Close Similarity to Peptidoglycan Deacetylases. J.Biol.Chem., 281, 2006
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2C7A
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![BU of 2c7a by Molmil](/molmil-images/mine/2c7a) | STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX | Descriptor: | 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*AP*AP *CP*TP*GP*TP*TP*CP*TP*G)-3', 5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*TP *TP*TP*GP*TP*TP*CP*TP*G)-3', PROGESTERONE RECEPTOR, ... | Authors: | Roemer, S.C, Donham, D.C, Sherman, L, Pon, V.H, Edwards, D.P, Churchill, M.E.A. | Deposit date: | 2005-11-19 | Release date: | 2006-08-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the Progesterone Receptor-Deoxyribonucleic Acid Complex: Novel Interactions Required for Binding to Half-Site Response Elements. Mol.Endocrinol., 20, 2006
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