2C6Q
Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP and NADPH
Summary for 2C6Q
Entry DOI | 10.2210/pdb2c6q/pdb |
Related | 2BZN |
Descriptor | GMP REDUCTASE 2, INOSINIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | tim barrel, metal-binding, nadp, oxidoreductase, potassium |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 8 |
Total formula weight | 313263.94 |
Authors | Kursula, P.,Stenmark, P.,Arrowsmith, C.,Berglund, H.,Edwards, A.,Ehn, M.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Kotenyova, T.,Nilsson-Ehle, P.,Ogg, D.,Persson, C.,Sagemark, J.,Schuler, H.,Sundstrom, M.,Thorsell, A.,Weigelt, J.,Nordlund, P. (deposition date: 2005-11-11, release date: 2005-11-30, Last modification date: 2023-12-13) |
Primary citation | Patton, G.C.,Stenmark, P.,Gollapalli, D.R.,Sevastik, R.,Kursula, P.,Flodin, S.,Schuler, H.,Swales, C.T.,Eklund, H.,Himo, F.,Nordlund, P.,Hedstrom, L. Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes. Nat.Chem.Biol., 7:950-, 2011 Cited by PubMed: 22037469DOI: 10.1038/NCHEMBIO.693 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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