2C6Q

Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP and NADPH

Summary for 2C6Q

• Entry DOI: 10.2210/pdb2c6q/pdb
• Related: 2BZN
• Descriptor: GMP REDUCTASE 2, INOSINIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: tim barrel, metal-binding, nadp, oxidoreductase, potassium
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 8
• Total formula weight: 313263.94

Authors

Kursula, P.,Stenmark, P.,Arrowsmith, C.,Berglund, H.,Edwards, A.,Ehn, M.,Graslund, S.,Hammarstrom, M.,Hallberg, B.M.,Kotenyova, T.,Nilsson-Ehle, P.,Ogg, D.,Persson, C.,Sagemark, J.,Schuler, H.,Sundstrom, M.,Thorsell, A.,Weigelt, J.,Nordlund, P. (deposition date: 2005-11-11, release date: 2005-11-30, Last modification date: 2023-12-13)

• Primary citation: Patton, G.C.,Stenmark, P.,Gollapalli, D.R.,Sevastik, R.,Kursula, P.,Flodin, S.,Schuler, H.,Swales, C.T.,Eklund, H.,Himo, F.,Nordlund, P.,Hedstrom, L.; Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes.; Nat.Chem.Biol., 7:950-, 2011; PubMed: 22037469; DOI: 10.1038/NCHEMBIO.693

Experimental method

X-RAY DIFFRACTION (1.7 Å)