2C6Q

Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP and NADPH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	GMP REDUCTASE 2	polymer	351	38157.5	8	UniProt (Q9P2T1) Pfam (PF00478)	HOMO SAPIENS (HUMAN)	GUANOSINE MONOPHOSPHATE REDUCTASE 2, GUANOSINE 5'-MONOPHOSPHATE OXIDOREDUCTASE 2
2	I, K, M, O, Q... (A, B, C, D, E...)	INOSINIC ACID	non-polymer		348.2	8	Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734)
3	J, L, N, P, R... (A, B, C, D, E...)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	7	Chemie (NDP)
4	AA, BA, CA, DA, EA... (D, E, F, G, H...)	water	water		18.0	2569	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: -9 - 9 (PDB: 2C6Q)
A, B, C, D, E, F, G, H: 10 - 341 (UniProt: Q9P2T1)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	305260.3
Non-Polymers*	Number of molecules	15
	Total formula weight	8003.6
All*	Total formula weight	313263.9

*Water molecules are not included.