PDB: 5653 resultsInfo pagesStatus searchChemie searchBIRD

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2RB8	High resolution design of a protein loop Descriptor: Tenascin Authors: Hu, X, Wang, H, Ke, H, Kuhlman, B. Deposit date: 2007-09-18 Release date: 2007-11-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: High-resolution design of a protein loop. Proc.Natl.Acad.Sci.Usa, 104, 2007
3VBT	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design Descriptor: 4-chloro-2-(1H-pyrazol-3-yl)phenol, Serine/threonine-protein kinase pim-1 Authors: Liu, J. Deposit date: 2012-01-02 Release date: 2012-03-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
6LDW	Structure of antibody C9 in complex with methylated peptide Descriptor: CHLORIDE ION, Fab heavy chain, Fab light chain, ... Authors: Caaveiro, J.M.M, Tsumoto, K. Deposit date: 2019-11-23 Release date: 2020-11-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for antigen recognition by methylated lysine-specific antibodies. J.Biol.Chem., 296, 2020
3VC4	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design Descriptor: (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, IMIDAZOLE, Serine/threonine-protein kinase pim-1 Authors: Liu, J. Deposit date: 2012-01-03 Release date: 2012-03-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
6OV9	Coiled-coil Trimer with Glu:p-nitrophenylalanine:Lys Triad Descriptor: Coiled-coil Trimer with Glu:p-nitrophenylalanine:Lys Triad Authors: Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. Deposit date: 2019-05-07 Release date: 2020-04-29 Last modified: 2020-05-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle. Biochemistry, 59, 2020
6OVS	Coiled-coil Trimer with Glu:Tyr:Lys Triad Descriptor: Coiled-coil Trimer with Glu:Tyr:Lys Triad, PENTAETHYLENE GLYCOL Authors: Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. Deposit date: 2019-05-08 Release date: 2020-04-29 Last modified: 2020-05-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle. Biochemistry, 59, 2020
6LDV	Structure antibody F9 in complex with methylated peptide Descriptor: Fab heavy chain, Fab light chain, GLY-M3L-GLY-GLY-THR-TYR-PRO, ... Authors: Caaveiro, J.M.M, Tsumoto, K. Deposit date: 2019-11-23 Release date: 2020-11-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for antigen recognition by methylated lysine-specific antibodies. J.Biol.Chem., 296, 2020
6OSD	Coiled-coil Trimer with Glu:Phe:Lys Triad Descriptor: Coiled-coil Trimer with Glu:Phe:Lys Triad Authors: Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. Deposit date: 2019-05-01 Release date: 2020-04-29 Last modified: 2020-05-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle. Biochemistry, 59, 2020
6OLO	Controlling the Self-Assembly of Synthetic Metal-Coordinating Coiled-Coil Peptides: Hexagonal Lattice from a Trimeric Coiled Coil Descriptor: COPPER (II) ION, Designed trimeric coiled coil peptide Authors: Schieb, K.A, Horne, W.S. Deposit date: 2019-04-16 Release date: 2020-03-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Understanding and controlling the metal-directed assembly of terpyridine-functionalized coiled-coil peptides. Chem.Commun.(Camb.), 55, 2019
2RLZ	Solid-State MAS NMR structure of the dimer Crh Descriptor: HPr-like protein crh Authors: Loquet, A, Bardiaux, B, Gardiennet, C, Blanchet, C, Baldus, M, Nilges, M, Malliavin, T, Bockmann, A. Deposit date: 2007-09-04 Release date: 2008-06-17 Last modified: 2024-05-29 Method: SOLID-STATE NMR Cite: 3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints. J.Am.Chem.Soc., 130, 2008
3VBV	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design Descriptor: 8-hydroxyquinoline-2-carboxamide, Serine/threonine-protein kinase pim-1 Authors: Liu, J. Deposit date: 2012-01-02 Release date: 2012-03-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
6OVV	Coiled-coil Trimer with Glu:4-pyridinylalanine:Lys Triad Descriptor: Coiled-coil Trimer with Glu:4-pyridinylalanine:Lys Triad Authors: Smith, M.S, Stern, K.L, Billings, W.M, Price, J.L. Deposit date: 2019-05-08 Release date: 2020-04-29 Last modified: 2020-05-20 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle. Biochemistry, 59, 2020
3VBQ	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design Descriptor: (5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1 Authors: Liu, J. Deposit date: 2012-01-02 Release date: 2012-03-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
7YTO	The Crystal Structure Analysis of Creatine Amidinohydrolase from Alcaligenes sp. KS-85 Descriptor: Creatine amidinohydrolase Authors: Chen, R.S. Deposit date: 2022-08-15 Release date: 2023-08-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Creatinase: Using Increased Entropy to Improve the Activity and Thermostability. J.Phys.Chem.B, 127, 2023
3VBY	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design Descriptor: IMIDAZOLE, Serine/threonine-protein kinase pim-1, furan-2-yl(1H-indol-3-yl)methanone Authors: Liu, J. Deposit date: 2012-01-02 Release date: 2012-03-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
5I8B	CBP in complex with Cpd23 ((R)-6-(3-(benzyloxy)phenyl)-4-methyl-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one) Descriptor: (4R)-6-[3-(benzyloxy)phenyl]-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Murray, J.M. Deposit date: 2016-02-18 Release date: 2016-04-20 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.5218 Å) Cite: Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7, 2016
6LRB	The A form apo structure of NrS-1 C terminal region-CTR Descriptor: MAGNESIUM ION, Primase Authors: Chen, X, Gan, J. Deposit date: 2020-01-15 Release date: 2020-04-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase. Nucleic Acids Res., 48, 2020
6LT0	cryo-EM structure of C9ORF72-SMCR8-WDR41 Descriptor: Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 Authors: Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. Deposit date: 2020-01-21 Release date: 2020-04-15 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
7Q3K	Computationally designed thioredoxin subjected to stability optimizing mutations. Descriptor: SULFATE ION, eMM9 Authors: Norrild, R.K, Johansson, K.E, O'Shea, C, Lindorff-Larsen, K, Winther, J.R, Morth, J.P. Deposit date: 2021-10-27 Release date: 2022-11-16 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Increasing protein stability by inferring substitution effects from high-throughput experiments. Cell Rep Methods, 2, 2022
4V7Q	Atomic model of an infectious rotavirus particle Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Core scaffold protein, ... Authors: Settembre, E.C, Chen, J.Z, Dormitzer, P.R, Grigorieff, N, Harrison, S.C. Deposit date: 2010-05-13 Release date: 2014-07-09 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Atomic model of an infectious rotavirus particle. Embo J., 30, 2011
6M2V	Crystal structure of UHRF1 SRA complexed with fully-mCHG DNA. Descriptor: DNA (5'-D(*TP*CP*AP*CP*GP*(5CM)P*TP*GP*CP*GP*TP*GP*A)-3'), E3 ubiquitin-protein ligase UHRF1 Authors: Abhishek, S, Nakarakanti, N.K, Deeksha, W, Rajakumara, E. Deposit date: 2020-03-01 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA. Int.J.Biol.Macromol., 170, 2021
6PA7	The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. Descriptor: CHLORIDE ION, DNA (167-MER), DNA (cytosine-5)-methyltransferase 3A, ... Authors: Xu, T.H, Liu, M, Zhou, X.E, Liang, G, Zhao, G, Xu, H.E, Melcher, K, Jones, P.A. Deposit date: 2019-06-11 Release date: 2020-06-17 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature, 586, 2020
6G65	Crystal structure of a parallel six-helix coiled coil CC-Type2-VV Descriptor: CC-Type2-VV Authors: Rhys, G.G, Brady, R.L, Woolfson, D.N. Deposit date: 2018-04-01 Release date: 2018-10-17 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nat Commun, 9, 2018
6G6C	Crystal structure of a parallel six-helix coiled coil CC-Type2-LL-L17E Descriptor: CC-Type2-LL-L17E Authors: Rhys, G.G, Brady, R.L, Woolfson, D.N. Deposit date: 2018-04-01 Release date: 2018-10-17 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Maintaining and breaking symmetry in homomeric coiled-coil assemblies. Nat Commun, 9, 2018
6FP9	Crystal structure of anti-mTFP1 DARPin 1238_E11 Descriptor: 1,2-ETHANEDIOL, DARPin 1238_E11, SULFATE ION Authors: Jakob, R.P, Vigano, M.A, Bieli, D, Matsuda, S, Schaefer, J.V, Pluckthun, A, Affolter, M, Maier, T. Deposit date: 2018-02-09 Release date: 2018-10-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations. Biol Open, 7, 2018

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