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5TEF	Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, Gem-associated protein 5, ... Authors: Chao, X, Tempel, W, Bian, C, He, H, Cerovina, T, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2016-09-21 Release date: 2016-10-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev., 30, 2016
5TFR	Crystal structure of Zika Virus NS5 protein Descriptor: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Longenecker, K.L, Upadhyay, A.K. Deposit date: 2016-09-26 Release date: 2016-10-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.05 Å) Cite: Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5. Acta Crystallogr F Struct Biol Commun, 73, 2017
5TIL	Murine class I major histocompatibility complex H-2 Db in complex with LCMV-derived GP33 altered peptide V3P and T-cell receptor P14 Descriptor: Alpha chain of murine P14 T cell receptor, Beta chain of murine T cell receptor P14, Beta-2-microglobulin, ... Authors: Achour, A, Sandalova, T, Allerbring, E.B. Deposit date: 2016-10-03 Release date: 2017-11-01 Method: X-RAY DIFFRACTION (2.83 Å) Cite: Ternary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant To be published
5TJ2	Gasdermin-B C-terminal domain containing the polymorphism residues Gly299:Ser306 fused to maltose binding protein Descriptor: Sugar ABC transporter substrate-binding protein,Gasdermin-B fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Chao, L.K, Herzberg, O. Deposit date: 2016-10-03 Release date: 2017-02-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Human Gasdermin-B and disease: Sulfatide Binding, Caspase cleavage, and Structural impact of Asthma- and IBS-Associated Polymorphism Proc.Natl.Acad.Sci.Usa, 2017
5TJR	X-ray Crystal structure of a methylmalonate semialdehyde dehydrogenase from Pseudomonas sp. AAC Descriptor: ADENOSINE-5'-DIPHOSPHATE, Methylmalonate-semialdehyde dehydrogenase Authors: Peat, T.S, Newman, J. Deposit date: 2016-10-05 Release date: 2017-01-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida. Biochemistry, 55, 2016
5T6E	Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a dichloro-dimethylpyridyl-methoxy-phenyl-pyridyl-piperazine ligand Descriptor: 1-(4-{3,5-dichloro-4-[(2,4-dimethylpyridin-3-yl)methoxy]phenyl}pyridin-2-yl)piperazine, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2016-09-01 Release date: 2017-09-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. J. Med. Chem., 60, 2017
5T6M	Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound Descriptor: (betaS)-beta-methyl-L-tryptophan, PHOSPHATE ION, SODIUM ION, ... Authors: Buller, A.R, van Roye, P, Arnold, F.H. Deposit date: 2016-09-01 Release date: 2016-12-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry, 55, 2016
5TBX	hnRNP A18 RNA Recognition Motif Descriptor: ACETATE ION, Cold-inducible RNA-binding protein, NICKEL (II) ION Authors: Coburn, K.M, Melville, Z, Aligholizadeh, E, Roth, B.M, Varney, K.M, Weber, D.J. Deposit date: 2016-09-13 Release date: 2017-04-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.767 Å) Cite: Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif. Acta Crystallogr F Struct Biol Commun, 73, 2017
5TDN	Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces Descriptor: GLYCEROL, anti-HER2 Fab Heavy Chain, anti-HER2 Fab Light Chain Authors: Yin, Y, Carter, P.J. Deposit date: 2016-09-19 Release date: 2016-12-07 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal structure of the Fab fragment of anti-HER2 antibody 4D5 with redesigned heavy and light chain interfaces To Be Published
5TFU	Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex Descriptor: (4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Hsu, M.H, Johnson, E.F. Deposit date: 2016-09-26 Release date: 2017-01-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. J. Med. Chem., 60, 2017
5THP	Rhodocetin in complex with the integrin alpha2-A domain Descriptor: CHLORIDE ION, GLYCEROL, Integrin alpha-2, ... Authors: McDougall, M, Orriss, G.L, Stetefeld, J. Deposit date: 2016-09-30 Release date: 2017-08-02 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.006 Å) Cite: Dramatic and concerted conformational changes enable rhodocetin to block alpha 2 beta 1 integrin selectively. PLoS Biol., 15, 2017
5T63	The HhoA protease from Synechocystis sp. PCC 6803 Descriptor: ALA-ALA-ALA-ALA, MAGNESIUM ION, Putative serine protease HhoA Authors: Persson, K, Hall, M, Funk, C. Deposit date: 2016-09-01 Release date: 2017-01-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The HhoA protease from Synechocystis sp. PCC 6803 - Novel insights into structure and activity regulation. J. Struct. Biol., 198, 2017
5T69	The HhoA protease from Synechocystis sp. PCC 6803, active site mutant Descriptor: ACETATE ION, MAGNESIUM ION, Putative serine protease HhoA Authors: Persson, K, Hall, M, Funk, C. Deposit date: 2016-09-01 Release date: 2017-01-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The HhoA protease from Synechocystis sp. PCC 6803 - Novel insights into structure and activity regulation. J. Struct. Biol., 198, 2017
5T6D	2.10 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (hexagonal form) Descriptor: 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy)propyl]sulfonyl}-L- alaninamide, Genome polyprotein Authors: Lovell, S, Battaile, K.P, Mehzabeen, N, Kankanamalage, A.C.G, Kim, Y, Rathnayake, A.D, Damalanka, V.C, Weerawarna, P.M, Doyle, S.T, Alsoudi, A.F, Dissanayake, D.M.P, Chang, K.-O, Groutas, W.C. Deposit date: 2016-09-01 Release date: 2016-11-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. Eur J Med Chem, 126, 2016
5T6J	Structure of the MIND Complex Shows a Regulatory Focus of Yeast Kinetochore Assembly Descriptor: Kinetochore protein SPC24, Kinetochore protein SPC25, Kinetochore-associated protein DSN1 Authors: Valverde, R, Jenni, S, Dimitrova, Y, Khin, Y, Harrison, S.C. Deposit date: 2016-09-01 Release date: 2016-11-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.752 Å) Cite: Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell, 167, 2016
5T5U	Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a methylpyridyl-dipihenyl-pyridine ligand Descriptor: 2-methyl-3-({[3'-(piperidin-4-yl)[1,1'-biphenyl]-4-yl]oxy}methyl)pyridine, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2016-08-31 Release date: 2017-09-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. J. Med. Chem., 60, 2017
5T6F	1.90 A resolution structure of Norovirus 3CL protease in complex with the dipeptidyl inhibitor 7l (orthorhombic P form) Descriptor: 3-cyclohexyl-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-N~2~-{[3-(4-methoxyphenoxy)propyl]sulfonyl}-L- alaninamide, Genome polyprotein Authors: Lovell, S, Battaile, K.P, Mehzabeen, N, Kankanamalage, A.C.G, Kim, Y, Rathnayake, A.D, Damalanka, V.C, Weerawarna, P.M, Doyle, S.T, Alsoudi, A.F, Dissanayake, D.M.P, Chang, K.-O, Groutas, W.C. Deposit date: 2016-09-01 Release date: 2016-11-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. Eur J Med Chem, 126, 2016

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