7U6Y
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7U7M
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7S5X
| Human KATP channel in open conformation, focused on Kir and one SUR, position 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5Y
| Human KATP channel in open conformation, focused on Kir and one SUR, position 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S61
| Human KATP channel in open conformation, focused on Kir and one SUR, position 5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S5Z
| Human KATP channel in open conformation, focused on Kir and one SUR, position 3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S60
| Human KATP channel in open conformation, focused on Kir and one SUR, position 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2021-09-12 | Release date: | 2021-12-01 | Last modified: | 2021-12-08 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular structure of an open human K ATP channel. Proc.Natl.Acad.Sci.USA, 118, 2021
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4XDK
| Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine | Descriptor: | (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2014-12-19 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
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4XDL
| Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative. | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[2-bromanyl-4-(trifluoromethyl)phenoxy]-N-methyl-3-phenyl-propan-1-amine, CADMIUM ION, ... | Authors: | Mackenzie, A, Pike, A.C.W, Dong, Y.Y, Mukhopadhyay, S, Ruda, G.F, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2014-12-19 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
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7U1E
| CryoEM structure of the pancreatic ATP-sensitive potassium channel bound to ATP with Kir6.2-CTD in the down conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Shyng, S.L, Sung, M.W, Driggers, C.M. | Deposit date: | 2022-02-21 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (4.52 Å) | Cite: | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7UAA
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7U24
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... | Authors: | Shyng, S.L, Sung, M.W, Driggers, C.M. | Deposit date: | 2022-02-23 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7U2X
| Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the down conformation | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Shyng, S.L, Sung, M.W, Driggers, C.M. | Deposit date: | 2022-02-25 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022
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7SIT
| Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXYGEN ATOM, POTASSIUM ION, ... | Authors: | Reddi, R, Matulef, K, Riederer, E.A, Whorton, M.R, Valiyaveetil, F.I. | Deposit date: | 2021-10-14 | Release date: | 2022-05-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv, 8, 2022
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6O9U
| KirBac3.1 at a resolution of 2 Angstroms | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3,3',3''-phosphoryltripropanoic acid, BARIUM ION, ... | Authors: | Gulbis, J.M, Clarke, O.B. | Deposit date: | 2019-03-15 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A constricted opening in Kir channels does not impede potassium conduction. Nat Commun, 11, 2020
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6O9T
| KirBac3.1 mutant at a resolution of 4.1 Angstroms | Descriptor: | 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione, Inward rectifier potassium channel Kirbac3.1, POTASSIUM ION | Authors: | Gulbis, J.M, Black, K.A, Miller, D.M. | Deposit date: | 2019-03-15 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.01 Å) | Cite: | A constricted opening in Kir channels does not impede potassium conduction. Nat Commun, 11, 2020
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6O9V
| KirBac3.1 mutant at a resolution of 3.1 Angstroms | Descriptor: | 1,1-Methanediyl Bismethanethiosulfonate, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, Inward rectifier potassium channel Kirbac3.1, ... | Authors: | Gulbis, J.M, Black, K.A, Miller, D.M. | Deposit date: | 2019-03-15 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.094 Å) | Cite: | A constricted opening in Kir channels does not impede potassium conduction. Nat Commun, 11, 2020
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4XDJ
| Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, ... | Authors: | Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2014-12-19 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
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7SIZ
| C-type inactivation in a voltage gated K+ channel | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Voltage gated potassium channel Kv1.2-Kv2.1, ... | Authors: | Reddi, R, Riederer, E.A, Matulef, K, Whorton, M.R, Valiyaveetil, F.I. | Deposit date: | 2021-10-15 | Release date: | 2022-05-04 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv, 8, 2022
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6CNM
| Cryo-EM structure of the human SK4/calmodulin channel complex | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Lee, C.H, MacKinnon, R. | Deposit date: | 2018-03-08 | Release date: | 2018-05-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science, 360, 2018
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6BY3
| Open and conductive conformation of KcsA-T75A mutant | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | Deposit date: | 2017-12-19 | Release date: | 2018-05-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BY2
| Closed and deep-inactivated conformation of KcsA-T75A mutant | Descriptor: | Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ... | Authors: | Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G. | Deposit date: | 2017-12-19 | Release date: | 2018-05-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Inverted allosteric coupling between activation and inactivation gates in K+channels. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4JTD
| Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of Charybdotoxin | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | Authors: | Banerjee, A, Lee, A, Campbell, E, MacKinnon, R. | Deposit date: | 2013-03-23 | Release date: | 2013-06-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife, 2, 2013
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6HDC
| Crystal structure of the potassium channel MtTMEM175 T38A variant in complex with a Nanobody-MBP fusion protein | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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6HDB
| Crystal structure of the potassium channel MtTMEM175 with zinc | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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