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1L26	REPLACEMENTS OF PRO86 IN PHAGE T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Bell, J.A, Dao-Pin, S, Matthews, B.W. Deposit date: 1989-05-01 Release date: 1990-01-15 Last modified: 2022-11-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability. Science, 239, 1988
1DQ9	COMPLEX OF CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG-COA Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, PROTEIN (HMG-COA REDUCTASE) Authors: Istvan, E.S, Palnitkar, M, Buchanan, S.K, Deisenhofer, J. Deposit date: 1999-12-30 Release date: 2000-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J., 19, 2000
1DRU	ESCHERICHIA COLI DHPR/NADH COMPLEX Descriptor: DIHYDRODIPICOLINATE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE Authors: Reddy, S.G, Scapin, G, Blanchard, J.S. Deposit date: 1996-06-28 Release date: 1997-01-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Interaction of pyridine nucleotide substrates with Escherichia coli dihydrodipicolinate reductase: thermodynamic and structural analysis of binary complexes. Biochemistry, 35, 1996
6I53	Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ... Authors: Laverty, D, Desai, R, Uchanski, T, Masiulis, S, Wojciech, J.S, Malinauskas, T, Zivanov, J, Pardon, E, Steyaert, J, Miller, K.W, Aricescu, A.R. Deposit date: 2018-11-12 Release date: 2019-01-02 Last modified: 2022-03-30 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer. Nature, 565, 2019
1L44	CUMULATIVE SITE-DIRECTED CHARGE-CHANGE REPLACEMENTS IN BACTERIOPHAGE T4 LYSOZYME SUGGEST THAT LONG-RANGE ELECTROSTATIC INTERACTIONS CONTRIBUTE LITTLE TO PROTEIN STABILITY Descriptor: T4 LYSOZYME Authors: Daopin, S, Matthews, B.W. Deposit date: 1991-01-28 Release date: 1991-10-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cumulative site-directed charge-change replacements in bacteriophage T4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. J.Mol.Biol., 221, 1991
4DVY	Crystal structure of the Helicobacter pylori CagA oncoprotein Descriptor: Cytotoxicity-associated immunodominant antigen Authors: Hayashi, T, Senda, M, Morohashi, H, Higashi, H, Horio, M, Kashiba, Y, Nagase, L, Sasaya, D, Shimizu, T, Venugopalan, N, Kumeta, H, Noda, N, Inagaki, F, Senda, T, Hatakeyama, M. Deposit date: 2012-02-23 Release date: 2012-07-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA Cell Host Microbe, 12, 2012
1L58	ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, T4 LYSOZYME Authors: Nicholson, H, Matthews, B.W. Deposit date: 1991-05-06 Release date: 1991-10-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: To be Published
1LJ3	CRYSTAL STRUCTURE OF MONOCLINIC LYSOZYME GROWN AT PH 4.6 Descriptor: Lysozyme C, NITRATE ION Authors: Saraswathi, N.T, Sankaranarayanan, R, Vijayan, M. Deposit date: 2002-04-19 Release date: 2002-10-19 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Effect of stabilizing additives on the structure and hydration of proteins: a study involving monoclinic lysozyme. Acta Crystallogr.,Sect.D, 58, 2002
1LJK	CRYSTAL STRUCTURE OF MONOCLINIC LYSOZYME GROWN IN PRESENCE OF 15% TREHALOSE Descriptor: Lysozyme C, NITRATE ION Authors: Saraswathi, N.T, Sankaranarayanan, R, Vijayan, M. Deposit date: 2002-04-21 Release date: 2002-10-19 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Effect of stabilizing additives on the structure and hydration of proteins: a study involving monoclinic lysozyme. Acta Crystallogr.,Sect.D, 58, 2002
1L64	TOLERANCE OF T4 LYSOZYME TO MULTIPLE XAA (RIGHT ARROW) ALA SUBSTITUTIONS: A POLYALANINE ALPHA-HELIX CONTAINING TEN CONSECUTIVE ALANINES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Heinz, D, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc.Natl.Acad.Sci.USA, 89, 1992
1DYE	DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1993-05-13 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J.Mol.Biol., 235, 1994
1LL7	STRUCTURE OF THE E171Q MUTANT OF C. IMMITIS CHITINASE 1 Descriptor: CHITINASE 1 Authors: Bortone, K, Monzingo, A.F, Ernst, S, Robertus, J.D. Deposit date: 2002-04-26 Release date: 2002-12-18 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: THE STRUCTURE OF AN ALLOSAMIDIN COMPLEX WITH THE COCCIDIOIDES IMMITIS CHITINASE DEFINES A ROLE FOR A SECOND ACID RESIDUE IN SUBSTRATE-ASSISTED MECHANISM J.Mol.Biol., 320, 2002
3GHU	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Forth stage of radiation damage. Descriptor: Aldose reductase, CITRIC ACID, IDD594, ... Authors: Petrova, T, Ginell, S, Hazemann, I, Mitschler, A, Podjarny, A, Joachimiak, A. Deposit date: 2009-03-04 Release date: 2009-03-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.2 Å) Cite: X-ray-radiation-induced cooperative atomic movements in protein. J.Mol.Biol., 387, 2009
1L71	MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Zhang, X, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992
4TM1	Kutzneria sp. 744 ornithine N-hydroxylase, KtzI-FADred-NADP+-Br Descriptor: BROMIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, KtzI, ... Authors: Setser, J.W, Drennan, C.L. Deposit date: 2014-05-30 Release date: 2014-09-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase. Biochemistry, 53, 2014
1PRN	REFINED STRUCTURE OF PORIN FROM RHODOPSEUDOMONAS BLASTICA AND COMPARISON WITH THE PORIN FROM RHODOBACTER CAPSULATUS Descriptor: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, PORIN Authors: Kreusch, A, Schulz, G.E. Deposit date: 1994-07-13 Release date: 1994-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Refined structure of the porin from Rhodopseudomonas blastica. Comparison with the porin from Rhodobacter capsulatus. J.Mol.Biol., 243, 1994
4RQ5	Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine (8-oxoG)and dATP soaked with MgCl2 for 60 s Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CHLORIDE ION, ... Authors: Vyas, R, Suo, Z. Deposit date: 2014-10-31 Release date: 2015-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography. J.Am.Chem.Soc., 137, 2015
3HHN	Crystal structure of class I ligase ribozyme self-ligation product, in complex with U1A RBD Descriptor: Class I ligase ribozyme, self-ligation product, MAGNESIUM ION, ... Authors: Shechner, D.M, Grant, R.A, Bagby, S.C, Bartel, D.P. Deposit date: 2009-05-15 Release date: 2009-11-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.987 Å) Cite: Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science, 326, 2009
1L76	TOLERANCE OF T4 LYSOZYME TO PROLINE SUBSTITUTIONS WITHIN THE LONG INTERDOMAIN ALPHA-HELIX ILLUSTRATES THE ADAPTABILITY OF PROTEINS TO POTENTIALLY DESTABILIZING LESIONS Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME Authors: Sauer, U, Matthews, B.W. Deposit date: 1991-09-23 Release date: 1991-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions. J.Biol.Chem., 267, 1992
1DWH	Study on radiation damage on a cryocooled crystal. Part 4: Structure after irradiation with 27.2*10e15 photons/mm2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... Authors: Burmeister, W.P. Deposit date: 1999-12-05 Release date: 2000-03-03 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Changes in a Cryo-Cooled Protein Crystal due to Radiation Damage Acta Crystallogr.,Sect.D, 56, 2000
1LQ2	Crystal structure of barley beta-D-glucan glucohydrolase isoenzyme Exo1 in complex with gluco-phenylimidazole Descriptor: (5R,6R,7S,8S)-5-(HYDROXYMETHYL)-2-PHENYL-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Hrmova, M, De Gori, R, Smith, B.J, Vasella, A, Varghese, J.N, Fincher, G.B. Deposit date: 2002-05-09 Release date: 2003-11-18 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Three-dimensional Structure of the Barley {beta}-D-Glucan Glucohydrolase in Complex with a Transition State Mimic. J.Biol.Chem., 279, 2004
6FZE	BBE31 from Lyme disease agent Borrelia (Borreliella) burgdorferi playing a vital role in successful colonization of the mammalian host (native data) Descriptor: GLUTATHIONE, Putative surface protein, SULFATE ION Authors: Brangulis, K, Akopjana, I, Petrovskis, I, Kazaks, A, Tars, K. Deposit date: 2018-03-14 Release date: 2019-03-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.26 Å) Cite: BBE31 from the Lyme disease agent Borrelia burgdorferi, known to play an important role in successful colonization of the mammalian host, shows the ability to bind glutathione. Biochim Biophys Acta Gen Subj, 1864, 2019
2Z4V	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and GGPP (inhibitory site) Descriptor: GERANYLGERANYL DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION Authors: Chen, C.K.-M, Guo, R.T, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. Deposit date: 2007-06-26 Release date: 2008-07-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
2Z78	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806 Descriptor: 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium, Geranylgeranyl pyrophosphate synthetase Authors: Chen, C.K.-M, Guo, R.T, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. Deposit date: 2007-08-16 Release date: 2008-07-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
1L91	SIMILAR HYDROPHOBIC REPLACEMENTS OF LEU 99 AND PHE 153 WITHIN THE CORE OF T4 LYSOZYME HAVE DIFFERENT STRUCTURAL AND THERMODYNAMIC CONSEQUENCES Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME Authors: Eriksson, A.E, Matthews, B.W. Deposit date: 1992-01-21 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J.Mol.Biol., 229, 1993

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