5C6V
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![BU of 5c6v by Molmil](/molmil-images/mine/5c6v) | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal domain (1-209) in complex with Arabidopsis NINJA peptide | Descriptor: | AFP homolog 2, ASPR2 protein | Authors: | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | Deposit date: | 2015-06-23 | Release date: | 2015-08-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors. Sci Adv, 1, 2015
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1P2G
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![BU of 1p2g by Molmil](/molmil-images/mine/1p2g) | Crystal Structure of Glycogen Phosphorylase B in complex with Gamma Cyclodextrin | Descriptor: | Cyclooctakis-(1-4)-(alpha-D-glucopyranose), Glycogen phosphorylase, muscle form, ... | Authors: | Pinotsis, N, Leonidas, D.D, Chrysina, E.D, Oikonomakos, N.G, Mavridis, I.M. | Deposit date: | 2003-04-15 | Release date: | 2003-09-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The binding of beta- and gamma-cyclodextrins to glycogen phosphorylase b: Kinetic and crystallographic studies. Protein Sci., 12, 2003
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7KCC
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![BU of 7kcc by Molmil](/molmil-images/mine/7kcc) | Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270 | Descriptor: | 1,2-ETHANEDIOL, 3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-[(pyridin-2-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ... | Authors: | Padyana, A, Jin, L. | Deposit date: | 2020-10-05 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J.Med.Chem., 64, 2021
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5F07
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![BU of 5f07 by Molmil](/molmil-images/mine/5f07) | Crystal structure of glutathione transferase F8 from Populus trichocarpa | Descriptor: | GLUTATHIONE, Putative glutathione S-transferase family protein | Authors: | Didierjean, C, Rouhier, N, Pegeot, H, Gense, F. | Deposit date: | 2015-11-27 | Release date: | 2016-12-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural plasticity among glutathione transferase Phi members: natural combination of catalytic residues confers dual biochemical activities. FEBS J., 284, 2017
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7K3Z
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![BU of 7k3z by Molmil](/molmil-images/mine/7k3z) | P. falciparum Cpn60 D474A mutant bound to ATP | Descriptor: | 60 kDa chaperonin, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Tolia, N.H, Shi, D, Nguyen, B. | Deposit date: | 2020-09-14 | Release date: | 2021-04-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.69 Å) | Cite: | Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding. Sci Rep, 11, 2021
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5F0L
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![BU of 5f0l by Molmil](/molmil-images/mine/5f0l) | Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Natural resistance-associated macrophage protein 2, ... | Authors: | Lucas, M, Gershlick, D, Vidaurrazaga, A, Rojas, A.L, Bonifacino, J.S, Hierro, A. | Deposit date: | 2015-11-27 | Release date: | 2016-12-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural Mechanism for Cargo Recognition by the Retromer Complex. Cell, 167, 2016
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1OQ9
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![BU of 1oq9 by Molmil](/molmil-images/mine/1oq9) | The Crystal Structure of the Complex between Stearoyl Acyl Carrier Protein Desaturase from Ricinus Communis (Castor Bean) and Acetate. | Descriptor: | ACETATE ION, Acyl-[acyl-carrier protein] desaturase, FE (III) ION | Authors: | Moche, M, Shanklin, J, Ghoshal, A.K, Lindqvist, Y. | Deposit date: | 2003-03-07 | Release date: | 2003-05-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Azide and Acetate Complexes plus two iron-depleted Crystal Structures of the Di-iron Enzyme delta9 Stearoyl-ACP Desaturase-Implications for Oxygen Activation and Catalytic Intermediates J.Biol.Chem., 278, 2003
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8TL6
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![BU of 8tl6 by Molmil](/molmil-images/mine/8tl6) | Cryo-EM structure of DDB1deltaB-DDA1-DCAF5 | Descriptor: | DDB1- and CUL4-associated factor 5, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1 | Authors: | Yue, H, Hunkeler, M, Roy Burman, S.S, Fischer, E.S. | Deposit date: | 2023-07-26 | Release date: | 2024-04-03 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature, 628, 2024
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4HD6
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![BU of 4hd6 by Molmil](/molmil-images/mine/4hd6) | Crystal Structure of Tyrosinase from Bacillus megaterium V218F mutant soaked in CuSO4 | Descriptor: | COPPER (II) ION, Tyrosinase | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2012-10-02 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Influencing the monophenolase/diphenolase activity ratio in tyrosinase. Biochim.Biophys.Acta, 1834, 2013
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8T6E
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![BU of 8t6e by Molmil](/molmil-images/mine/8t6e) | Crystal structure of T33-28.3: Deep-learning sequence design of co-assembling tetrahedron protein nanoparticles | Descriptor: | T33-28.3: A, T33-28.3: B | Authors: | Bera, A.K, de Haas, R.J, Kang, A, Sankaran, B, King, N.P. | Deposit date: | 2023-06-15 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Rapid and automated design of two-component protein nanomaterials using ProteinMPNN. Proc.Natl.Acad.Sci.USA, 121, 2024
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7PQ1
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![BU of 7pq1 by Molmil](/molmil-images/mine/7pq1) | Ligand-free crystal structure of a staphylococcal orthologue of CYP134A1 | Descriptor: | Cytochrome P450 protein, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Snee, M, Levy, C, Leys, D, Katariya, M, Munro, A.W. | Deposit date: | 2021-09-15 | Release date: | 2022-09-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Crystal structure of a staphylococcal orthologue of CYP134A1 (CYPX) in complex with Cyclo-L-leucyl-L-leucine To Be Published
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5F1I
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![BU of 5f1i by Molmil](/molmil-images/mine/5f1i) | MHC with 9-mer peptide | Descriptor: | 9-mer peptide, Beta2M, MHC class I DLA-88 | Authors: | Liu, J, Chai, Y, QI, J, Gao, G.F. | Deposit date: | 2015-11-30 | Release date: | 2016-11-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.904 Å) | Cite: | Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I J Immunol., 197, 2016
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1P3Y
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![BU of 1p3y by Molmil](/molmil-images/mine/1p3y) | MrsD from Bacillus sp. HIL-Y85/54728 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MrsD protein | Authors: | Blaesse, M, Kupke, T, Huber, R, Steinbacher, S. | Deposit date: | 2003-04-19 | Release date: | 2003-08-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structure of MrsD, an FAD-binding protein of the HFCD family. Acta Crystallogr.,Sect.D, 59, 2003
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8TK1
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![BU of 8tk1 by Molmil](/molmil-images/mine/8tk1) | Structure of Gabija AB complex 1 | Descriptor: | Endonuclease GajA, Gabija protein GajB | Authors: | Shen, Z.F, Yang, X.Y, Fu, T.M. | Deposit date: | 2023-07-25 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 2024
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7PFZ
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![BU of 7pfz by Molmil](/molmil-images/mine/7pfz) | |
8TO5
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![BU of 8to5 by Molmil](/molmil-images/mine/8to5) | Central rod disk in C1 symmetry of high-resolution phycobilisome quenched by OCP (local refinement) | Descriptor: | C-phycocyanin alpha subunit, C-phycocyanin beta subunit, PHYCOCYANOBILIN, ... | Authors: | Sauer, P.V, Sutter, M, Cupellini, L. | Deposit date: | 2023-08-02 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (1.87 Å) | Cite: | Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes. Sci Adv, 10, 2024
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4MFF
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![BU of 4mff by Molmil](/molmil-images/mine/4mff) | Structure of human DNA polymerase beta complexed with O6MG in the template base paired with incoming non-hydrolyzable TTP | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA polymerase beta, MAGNESIUM ION, ... | Authors: | Koag, M.C, Min, K, Monzingo, A.F, Lee, S. | Deposit date: | 2013-08-27 | Release date: | 2014-04-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta. J.Am.Chem.Soc., 136, 2014
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3EN4
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![BU of 3en4 by Molmil](/molmil-images/mine/3en4) | Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor | Descriptor: | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src | Authors: | Blair, J.A, Apsel, B, Knight, Z.A, Shokat, K.M. | Deposit date: | 2008-09-25 | Release date: | 2008-10-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol., 4, 2008
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7K5J
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![BU of 7k5j by Molmil](/molmil-images/mine/7k5j) | Structure of an E1-E2-ubiquitin thioester mimetic | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin, Ubiquitin-activating enzyme E1 1, ... | Authors: | Yuan, L, Lv, Z, Olsen, S.K. | Deposit date: | 2020-09-16 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification. Nat Commun, 12, 2021
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7JTR
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![BU of 7jtr by Molmil](/molmil-images/mine/7jtr) | Complex of maltose-binding protein (MBP) with single-chain Fv (scFv) | Descriptor: | CHLORIDE ION, Maltose/maltodextrin-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Loll, P.J. | Deposit date: | 2020-08-18 | Release date: | 2021-05-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A useful epitope tag derived from maltose binding protein. Protein Sci., 30, 2021
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2RL0
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![BU of 2rl0 by Molmil](/molmil-images/mine/2rl0) | |
5C90
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![BU of 5c90 by Molmil](/molmil-images/mine/5c90) | Staphylococcus aureus ClpP mutant - Y63A | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ATP-dependent Clp protease proteolytic subunit | Authors: | Ye, F, Liu, H, Zhang, J, Gan, J, Yang, C.-G. | Deposit date: | 2015-06-26 | Release date: | 2016-05-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure Acs Chem.Biol., 11, 2016
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1ORV
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![BU of 1orv by Molmil](/molmil-images/mine/1orv) | Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | Authors: | Engel, M, Hoffmann, T, Wagner, L, Wermann, M, Heiser, U, Kiefersauer, R, Huber, R, Bode, W, Demuth, H.U, Brandstetter, H. | Deposit date: | 2003-03-16 | Release date: | 2003-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism Proc.Natl.Acad.Sci.USA, 100, 2003
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1P77
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![BU of 1p77 by Molmil](/molmil-images/mine/1p77) | CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE | Descriptor: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, ACETATE ION, Shikimate 5-dehydrogenase | Authors: | Ye, S, von Delft, F, Brooun, A, Knuth, M.W, Swanson, R.V, McRee, D.E. | Deposit date: | 2003-04-30 | Release date: | 2003-08-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode J.Bacteriol., 185, 2003
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3A1M
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![BU of 3a1m by Molmil](/molmil-images/mine/3a1m) | A fusion protein of a beta helix region of gene product 5 and the foldon region of bacteriophage T4 | Descriptor: | POTASSIUM ION, chimera of thrombin cleavage site, Tail-associated lysozyme, ... | Authors: | Yokoi, N, Suzuki, A, Hikage, T, Koshiyama, T, Terauchi, M, Yutani, K, Kanamaru, S, Arisaka, F, Yamane, T, Watanabe, Y, Ueno, T. | Deposit date: | 2009-04-11 | Release date: | 2010-04-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Construction of Robust Bio-nanotubes using the Controlled Self-Assembly of Component Proteins of Bacteriophage T4 Small, 6, 2010
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