5EVI
| Crystal Structure of Beta-Lactamase/D-Alanine Carboxypeptidase from Pseudomonas syringae | Descriptor: | 1,2-ETHANEDIOL, Beta-Lactamase/D-Alanine Carboxypeptidase, SULFATE ION | Authors: | Kim, Y, Hatzos-Skintges, C, Endres, M, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-11-19 | Release date: | 2016-01-13 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Beta-Lactamase/D-Alanine Carboxypeptidase from Pseudomonas syringae To Be Published
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6T7L
| Crystal structure of AmpC from E.coli with Nacubactam (OP0595) | Descriptor: | (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-10-22 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65, 2021
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6T5Y
| Crystal structure of AmpC from E.coli with Zidebactam (WCK 5107) | Descriptor: | (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, Beta-lactamase, CHLORIDE ION, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-10-17 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65, 2021
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6T3D
| Crystal structure of AmpC from E.coli | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-10-10 | Release date: | 2020-06-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase from Escherichia coli . Biomolecules, 10, 2020
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5E2G
| Crystal Structure of D-alanine Carboxypeptidase AmpC from Burkholderia cenocepacia | Descriptor: | ACETIC ACID, Beta-lactamase, THIOCYANATE ION | Authors: | Kim, Y, Joachimiak, G, Endres, M, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-10-01 | Release date: | 2015-10-14 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | Crystal Structure of D-alanine Carboxypeptidase AmpC from Burkholderia cenocepacia To Be Published
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5E2H
| Crystal Structure of D-alanine Carboxypeptidase AmpC from Mycobacterium smegmatis | Descriptor: | Beta-lactamase, CHLORIDE ION, GLYCEROL | Authors: | Kim, Y, Hatzos-Skintges, C, Endres, M, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-10-01 | Release date: | 2015-10-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of D-alanine Carboxypeptidase AmpC from Mycobacterium smegmatis To Be Published
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6T35
| Crystal structure of AmpC from E.coli with Enmetazobactam (AAI-101) | Descriptor: | Beta-lactamase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-10-10 | Release date: | 2020-11-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors. Proc.Natl.Acad.Sci.USA, 119, 2022
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5GGW
| Crystal structure of Class C beta-lactamase | Descriptor: | Beta-lactamase, PHOSPHATE ION, SULFATE ION | Authors: | An, Y.J, Na, J.H, Cha, S.S. | Deposit date: | 2016-06-16 | Release date: | 2017-05-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.762 Å) | Cite: | Structural basis for the extended substrate spectrum of AmpC BER and structure-guided discovery of the inhibition activity of citrate against the class C beta-lactamases AmpC BER and CMY-10. Acta Crystallogr D Struct Biol, 72, 2016
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6UQS
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5GMX
| Crystal structure of a family VIII carboxylesterase | Descriptor: | Carboxylesterase, phenylmethanesulfonic acid | Authors: | An, Y.J, Cha, S.S. | Deposit date: | 2016-07-18 | Release date: | 2017-07-26 | Last modified: | 2019-02-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of EstSRT1, a family VIII carboxylesterase displaying hydrolytic activity toward oxyimino cephalosporins Biochem. Biophys. Res. Commun., 478, 2016
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6TPM
| Crystal structure of AmpC from E.coli with Relebactam (MK-7655) | Descriptor: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, ... | Authors: | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | Deposit date: | 2019-12-13 | Release date: | 2020-11-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65, 2021
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5GHY
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5GHZ
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5GKV
| Crystal Structure of a Novel Penicillin-Binding Protein (PBP) Homolog from Caulobacter crescentus | Descriptor: | Esterase A | Authors: | Ngo, T.D, Ryu, B.H, Kim, B.Y, Yoo, W.K, Lee, E.J, Lee, S.J, Kim, T.D, Kim, K.K. | Deposit date: | 2016-07-07 | Release date: | 2017-07-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Biochemical and Structural Analysis of a Novel Penicillin-Binding Protein (PBP) Homolog from Caulobacter crescentus To Be Published
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5GHX
| Crystal structure of beta-lactamase PenP mutant-E166H | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, Beta-lactamase | Authors: | Pan, X, Zhao, Y. | Deposit date: | 2016-06-21 | Release date: | 2017-01-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis J. Biol. Chem., 292, 2017
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5GSC
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1KE0
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1KVM
| X-ray Crystal Structure of AmpC WT beta-Lactamase in Complex with Covalently Bound Cephalothin | Descriptor: | 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, PHOSPHATE ION, beta-lactamase | Authors: | Beadle, B.M, Trehan, I, Focia, P.J, Shoichet, B.K. | Deposit date: | 2002-01-27 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase. Structure, 10, 2002
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4IVK
| Crystal structure of a fammily VIII carboxylesterase in a complex with cephalothin. | Descriptor: | CEPHALOTHIN GROUP, Carboxylesterases, SULFATE ION | Authors: | An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S. | Deposit date: | 2013-01-23 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase. Proteins, 81, 2013
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1KE4
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4IVI
| Crystal structure of a family VIII carboxylesterase. | Descriptor: | Carboxylesterase, SULFATE ION | Authors: | An, Y.J, Kim, M.-K, Jeong, C.-S, Cha, S.-S. | Deposit date: | 2013-01-23 | Release date: | 2013-06-19 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the beta-lactamase activity of EstU1, a family VIII carboxylesterase. Proteins, 81, 2013
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1FR1
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1FCM
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4OLD
| Crystal structure of AmpC beta-lactamase in complex with the product form of (6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | Descriptor: | (2R)-2-[(R)-amino(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Shoichet, B.K, Barelier, S. | Deposit date: | 2014-01-23 | Release date: | 2014-05-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Substrate deconstruction and the nonadditivity of enzyme recognition. J.Am.Chem.Soc., 136, 2014
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4OOY
| Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | Authors: | Lahiri, S.D, Olivier, N.B, Alm, R.A. | Deposit date: | 2014-02-04 | Release date: | 2014-08-20 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Avibactam and Class C beta-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance. Antimicrob.Agents Chemother., 58, 2014
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