6T5Y

Crystal structure of AmpC from E.coli with Zidebactam (WCK 5107)

Summary for 6T5Y

Entry DOI	10.2210/pdb6t5y/pdb
Descriptor	Beta-lactamase, DI(HYDROXYETHYL)ETHER, (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, ... (6 entities in total)
Functional Keywords	beta lactamase, antibiotic resistance, diazabicyclooctane, dbo, hydrolase
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	1
Total formula weight	40188.32
Authors	Lang, P.A.,Leissing, T.M.,Schofield, C.J.,Brem, J. (deposition date: 2019-10-17, release date: 2020-11-18, Last modification date: 2024-01-24)
Primary citation	Lang, P.A.,Leissing, T.M.,Page, M.G.P.,Schofield, C.J.,Brem, J. Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65:-, 2021 Cited by PubMed: 33199391 DOI: 10.1128/AAC.02073-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation