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7B07
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BU of 7b07 by Molmil
TgoT_6G12 apo
Descriptor: CALCIUM ION, DNA polymerase
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-18
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.099 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
4FLU
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BU of 4flu by Molmil
Pyrococcus abyssi B family DNA polymerase bound to a dsDNA, in edition mode
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ...
Authors:Gouge, J, Delarue, M.
Deposit date:2012-06-15
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
J.Mol.Biol., 423, 2012
8WPP
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BU of 8wpp by Molmil
Structure of monkeypox virus polymerase complex F8-A22-E4-H5 with endogenous DNA
Descriptor: A22R DNA polymerase processivity factor, DNA polymerase, E4R Uracil-DNA glycosylase, ...
Authors:Wang, X, Li, N, Gao, N.
Deposit date:2023-10-10
Release date:2023-11-29
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5.
Mol.Cell, 83, 2023
4FYD
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BU of 4fyd by Molmil
Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*GP*AP*GP*CP*GP*TP*G*TP*GP*TP*AP*CP*CP*CP*CP*TP*GP*CP*CP*CP*GP*CP*CP*G)-3'), DNA polymerase alpha catalytic subunit A, ...
Authors:Perera, R.L, Pellegrini, L.
Deposit date:2012-07-04
Release date:2013-02-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
6V93
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BU of 6v93 by Molmil
Structure of DNA Polymerase Zeta/DNA/dNTP Ternary Complex
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA, ...
Authors:Malik, R, Kopylov, M, Jain, R, Ubarrextena-Belandia, I, Aggarwal, A.K.
Deposit date:2019-12-13
Release date:2020-08-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis.
Nat.Struct.Mol.Biol., 27, 2020
8HM0
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BU of 8hm0 by Molmil
F8-A22-E4 complex of MPXV in trimeric form
Descriptor: DNA polymerase, DNA polymerase processivity factor component A20, E4R
Authors:Li, Y.N, Shen, Y.P, Hu, Z.W, Yan, R.H.
Deposit date:2022-12-02
Release date:2023-05-31
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant.
Sci Adv, 9, 2023
4FM0
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BU of 4fm0 by Molmil
Pyrococcus abyssi B family DNA polymerase bound to a dsDNA, in edition mode
Descriptor: DNA polymerase 1, GLYCEROL, MAGNESIUM ION, ...
Authors:Gouge, J, Delarue, M.
Deposit date:2012-06-15
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
J.Mol.Biol., 423, 2012
7B0H
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BU of 7b0h by Molmil
TgoT_6G12 Ternary complex
Descriptor: DNA (5'-D(P*AP*AP*CP*GP*GP*CP*AP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*AP*TP*T)-3'), DNA polymerase, ...
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-19
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
3SUQ
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BU of 3suq by Molmil
RB69 DNA Polymerase (Y567A) Ternary Complex with dCTP Opposite 2AP (AT rich sequence)
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*G)-3', ...
Authors:Xia, S, Konigsberg, W.H, Wang, J.
Deposit date:2011-07-11
Release date:2011-11-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase.
Biochemistry, 50, 2011
3K5N
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BU of 3k5n by Molmil
Crystal structure of E.coli Pol II-abasic DNA binary complex
Descriptor: DNA (5'-D(*GP*TP*CP*CP*TP*GP*(3DR)*TP*AP*CP*GP*CP*TP*AP*GP*GP*CP*AP*CP*A)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*TP*AP*GP*CP*GP*TP*AP*G)-3'), DNA polymerase II
Authors:Yang, W, Wang, F.
Deposit date:2009-10-07
Release date:2010-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural insight into translesion synthesis by DNA Pol II.
Cell(Cambridge,Mass.), 139, 2009
4FLZ
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BU of 4flz by Molmil
Pyrococcus abyssi B family DNA polymerase bound to a dsDNA, in edition mode
Descriptor: DNA polymerase 1, GLYCEROL, MAGNESIUM ION, ...
Authors:Gouge, J, Delarue, M.
Deposit date:2012-06-15
Release date:2012-08-29
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
J.Mol.Biol., 423, 2012
6P1H
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BU of 6p1h by Molmil
Cryo-EM Structure of DNA Polymerase Delta Holoenzyme
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
Authors:Jain, R, Rice, W, Aggarwal, A.K.
Deposit date:2019-05-19
Release date:2019-10-02
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure and dynamics of eukaryotic DNA polymerase delta holoenzyme.
Nat.Struct.Mol.Biol., 26, 2019
1WAF
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BU of 1waf by Molmil
DNA POLYMERASE FROM BACTERIOPHAGE RB69
Descriptor: DNA POLYMERASE, GUANOSINE
Authors:Wang, J, Satter, A.K.M.A, Wang, C.C, Karam, J.D, Konigsberg, W.H, Steitz, T.A.
Deposit date:1997-04-13
Release date:1998-01-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
Cell(Cambridge,Mass.), 89, 1997
8G9F
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BU of 8g9f by Molmil
Complete auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase
Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ...
Authors:Mullins, E.A, Chazin, W.J, Eichman, B.F.
Deposit date:2023-02-21
Release date:2023-04-12
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
7PMK
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BU of 7pmk by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7PMN
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BU of 7pmn by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7PFO
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BU of 7pfo by Molmil
Core human replisome
Descriptor: Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ...
Authors:Jones, M.J, Yeeles, J.T.P.
Deposit date:2021-08-11
Release date:2021-11-10
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Embo J., 40, 2021
5VU8
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BU of 5vu8 by Molmil
TNA polymerase, closed ternary complex
Descriptor: DNA polymerase, DNA template, DNA/TNA hybrid primer, ...
Authors:Chim, N, Chaput, J.C.
Deposit date:2017-05-18
Release date:2017-12-06
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for TNA synthesis by an engineered TNA polymerase.
Nat Commun, 8, 2017
7KC0
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BU of 7kc0 by Molmil
Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ...
Authors:Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E.
Deposit date:2020-10-04
Release date:2020-12-02
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
2ATQ
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BU of 2atq by Molmil
RB69 single-stranded DNA binding protein-DNA polymerase fusion
Descriptor: DNA polymerase, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ...
Authors:Sun, S, Geng, L, Shamoo, Y.
Deposit date:2005-08-25
Release date:2006-05-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and enzymatic properties of a chimeric bacteriophage RB69 DNA polymerase and single-stranded DNA binding protein with increased processivity.
Proteins, 65, 2006
6ISI
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BU of 6isi by Molmil
Structure of 9N-I DNA polymerase incorporation with 3'-CL in the active site
Descriptor: 3-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]propanoic acid, CALCIUM ION, DNA (5'-D(P*AP*CP*GP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ...
Authors:Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
Deposit date:2018-11-16
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
8J86
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BU of 8j86 by Molmil
Monkeypox virus DNA replication holoenzyme F8, A22 and E4 complex in a DNA binding form
Descriptor: CALCIUM ION, DNA (5'-D(P*AP*GP*CP*TP*GP*CP*TP*AP*TP*GP*TP*GP*AP*GP*AP*TP*TP*AP*AP*GP*TP*TP*AP*T)-3'), DNA (5'-D(P*GP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*GP*AP*TP*AP*AP*CP*TP*TP*AP*AP*TP*CP*TP*CP*AP*CP*AP*TP*AP*GP*CP*AP*GP*CP*TP*)-3'), ...
Authors:Xu, Y, Wu, Y, Wu, X, Zhang, Y, Yang, Y, Li, D, Yang, B, Gao, K, Zhang, Z, Dong, C.
Deposit date:2023-04-30
Release date:2024-05-01
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir.
Int.J.Biol.Macromol., 270, 2024
6ISH
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BU of 6ish by Molmil
Structure of 9N-I DNA polymerase incorporation with 3'-AL in the active site
Descriptor: CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*(DAL))-3'), ...
Authors:Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
Deposit date:2018-11-16
Release date:2019-08-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
8G9L
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BU of 8g9l by Molmil
DNA initiation subcomplex of Xenopus laevis DNA polymerase alpha-primase
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ...
Authors:Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F.
Deposit date:2023-02-21
Release date:2023-04-12
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
7QHS
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BU of 7qhs by Molmil
S. cerevisiae CMGE nucleating origin DNA melting
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
Authors:Lewis, J.S, Sousa, J.S, Costa, A.
Deposit date:2021-12-14
Release date:2022-06-15
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022

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