4CLL
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![BU of 4cll by Molmil](/molmil-images/mine/4cll) | Crystal structure of human soluble Adenylyl Cyclase in complex with bicarbonate | Descriptor: | 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, BICARBONATE ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OYI
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![BU of 4oyi by Molmil](/molmil-images/mine/4oyi) | Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone | Descriptor: | (4-azanyl-1,2,5-oxadiazol-3-yl)-phenyl-methanone, Adenylate cyclase type 10, GLYCEROL | Authors: | Vinkovic, M. | Deposit date: | 2014-02-12 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OYW
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![BU of 4oyw by Molmil](/molmil-images/mine/4oyw) | Crystal Structure of Human Soluble Adenylate Cyclase | Descriptor: | Adenylate cyclase type 10, CHLORIDE ION, GLYCEROL | Authors: | Vinkovic, M. | Deposit date: | 2014-02-13 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OZ3
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![BU of 4oz3 by Molmil](/molmil-images/mine/4oz3) | Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole | Descriptor: | 4-phenyl-3-(trifluoromethyl)-1H-pyrazole, Adenylate cyclase type 10, GLYCEROL | Authors: | Vinkovic, M. | Deposit date: | 2014-02-13 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OYB
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![BU of 4oyb by Molmil](/molmil-images/mine/4oyb) | Crystal Structure Analysis of the solAC | Descriptor: | Adenylate cyclase type 10, GLYCEROL, ethyl 2-[3-[(4-azanyl-1,2,5-oxadiazol-3-yl)carbonyl]phenoxy]ethanoate | Authors: | Vinkovic, M. | Deposit date: | 2014-02-11 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OYM
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![BU of 4oym by Molmil](/molmil-images/mine/4oym) | Human solAC Complexed with (4-Amino-furazan-3-yl)-(3-methoxy-phenyl)-methanone | Descriptor: | (4-azanyl-1,2,5-oxadiazol-3-yl)-(3-methoxyphenyl)methanone, Adenylate cyclase type 10, GLYCEROL | Authors: | Vinkovic, M. | Deposit date: | 2014-02-12 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4CLF
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![BU of 4clf by Molmil](/molmil-images/mine/4clf) | Crystal structure of human soluble Adenylyl Cyclase (Apo form) | Descriptor: | ACETATE ION, ADENYLATE CYCLASE TYPE 10, GLYCEROL | Authors: | Kleinboelting, S, Moniot, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-14 | Release date: | 2014-03-05 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OYZ
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![BU of 4oyz by Molmil](/molmil-images/mine/4oyz) | Human solAC Complexed with Bicarbonate | Descriptor: | Adenylate cyclase type 10, BICARBONATE ION, GLYCEROL | Authors: | Vinkovic, M. | Deposit date: | 2014-02-13 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4OYO
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![BU of 4oyo by Molmil](/molmil-images/mine/4oyo) | Human solAC Complexed with 4-(2-Chlorophenyl)-3-methyl-1H-pyrazole | Descriptor: | 4-(2-chlorophenyl)-5-methyl-1H-pyrazole, Adenylate cyclase type 10, GLYCEROL | Authors: | Vinkovic, M. | Deposit date: | 2014-02-12 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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5IV4
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![BU of 5iv4 by Molmil](/molmil-images/mine/5iv4) | Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1 | Descriptor: | 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... | Authors: | Kleinboelting, S, Steegborn, C. | Deposit date: | 2016-03-18 | Release date: | 2016-08-17 | Last modified: | 2022-11-30 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
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4CM2
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![BU of 4cm2 by Molmil](/molmil-images/mine/4cm2) | Crystal structure of human soluble Adenylyl Cyclase soaked with bisulfite | Descriptor: | ADENYLATE CYCLASE TYPE 10, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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8B75
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![BU of 8b75 by Molmil](/molmil-images/mine/8b75) | CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861 | Descriptor: | Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol | Authors: | Steegborn, C, Kehr, M. | Deposit date: | 2022-09-28 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65, 2022
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4CLS
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![BU of 4cls by Molmil](/molmil-images/mine/4cls) | Crystal structure of human soluble Adenylyl Cyclase with Pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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5IV3
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![BU of 5iv3 by Molmil](/molmil-images/mine/5iv3) | Crystal structure of human soluble adenylyl cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate and the allosteric inhibitor LRE1 | Descriptor: | 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... | Authors: | Kleinboelting, S, Steegborn, C. | Deposit date: | 2016-03-18 | Release date: | 2016-08-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
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4OYX
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![BU of 4oyx by Molmil](/molmil-images/mine/4oyx) | Human solAC Complexed with AMPCPP | Descriptor: | Adenylate cyclase type 10, CALCIUM ION, CHLORIDE ION, ... | Authors: | Vinkovic, M. | Deposit date: | 2014-02-13 | Release date: | 2014-04-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
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4UST
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![BU of 4ust by Molmil](/molmil-images/mine/4ust) | |
4CLP
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![BU of 4clp by Molmil](/molmil-images/mine/4clp) | Crystal structure of human soluble Adenylyl Cyclase complex with adenosine-3',5'-cyclic-monophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLZ
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![BU of 4clz by Molmil](/molmil-images/mine/4clz) | Crystal structure of human soluble Adenylyl Cyclase with Inhibitor 4, 4'-Diisothiocyano-2,2'-stilbenedisulfonic acid | Descriptor: | 1,2-ETHANEDIOL, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ACETATE ION, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4CLU
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![BU of 4clu by Molmil](/molmil-images/mine/4clu) | Crystal structure of human soluble Adenylyl Cyclase with pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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8CO7
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![BU of 8co7 by Molmil](/molmil-images/mine/8co7) | |
4CLT
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![BU of 4clt by Molmil](/molmil-images/mine/4clt) | Crystal structure of human soluble Adenylyl Cyclase with adenosine-3', 5'-cyclic-monophosphate and pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ADENYLATE CYCLASE TYPE 10, ... | Authors: | Kleinboelting, S, Weyand, M, Steegborn, C. | Deposit date: | 2014-01-15 | Release date: | 2014-03-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
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4USU
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![BU of 4usu by Molmil](/molmil-images/mine/4usu) | Crystal structure of human soluble Adenylyl Cyclase in complex with alpha,beta-methyleneadenosine-5'-triphosphate | Descriptor: | 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, CALCIUM ION, ... | Authors: | Kleinboelting, S, Steegborn, C. | Deposit date: | 2014-07-13 | Release date: | 2014-07-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Analysis of Human Soluble Adenylyl Cyclase and Crystal Structures of its Nucleotide Complexes -Implications for Cyclase Catalysis and Evolution. FEBS J., 281, 2014
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8IL7
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![BU of 8il7 by Molmil](/molmil-images/mine/8il7) | |
8CNH
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![BU of 8cnh by Molmil](/molmil-images/mine/8cnh) | |
4USV
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![BU of 4usv by Molmil](/molmil-images/mine/4usv) | |