6OLY
 
 | | Full-length MthK channel at 3.1 angstrom resolution | | Descriptor: | CALCIUM ION, Calcium-gated potassium channel MthK | | Authors: | Rothberg, B.S. | | Deposit date: | 2019-04-17 | | Release date: | 2019-12-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.112 Å) | | Cite: | Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling.
Nat Commun, 10, 2019
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2A9H
 | | NMR structural studies of a potassium channel / charybdotoxin complex | | Descriptor: | Voltage-gated potassium channel, charybdotoxin | | Authors: | Yu, L, Sun, C, Song, D, Shen, J, Xu, N, Gunasekera, A, Hajduk, P.J, Olejniczak, E.T. | | Deposit date: | 2005-07-11 | | Release date: | 2006-01-10 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.
Biochemistry, 44, 2005
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1R3J
 | | potassium channel KcsA-Fab complex in high concentration of Tl+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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1R3I
 | | potassium channel KcsA-Fab complex in Rb+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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1R3L
 | | potassium channel KcsA-Fab complex in Cs+ | | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CESIUM ION, ... | | Authors: | Zhou, Y, MacKinnon, R. | | Deposit date: | 2003-10-02 | | Release date: | 2003-11-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates
J.Mol.Biol., 333, 2003
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5U70
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7TKT
 | | SthK closed state, cAMP-bound in the presence of detergent | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | | Authors: | Rheinberger, J, Schmidpeter, P.A, Nimigean, C.M. | | Deposit date: | 2022-01-17 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Nat.Struct.Mol.Biol., 29, 2022
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7TJ5
 | | SthK closed state, cAMP-bound in the presence of POPA | | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | | Authors: | Schmidpeter, P.A, Nimigean, C.M. | | Deposit date: | 2022-01-14 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Nat.Struct.Mol.Biol., 29, 2022
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7TJ6
 | | SthK open state, cAMP-bound in the presence of POPA | | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | | Authors: | Schmidpeter, P.A, Nimigean, C.M. | | Deposit date: | 2022-01-14 | | Release date: | 2022-10-26 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family.
Nat.Struct.Mol.Biol., 29, 2022
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5U76
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7RTF
 | | SthK R120A Closed State | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | Authors: | Gao, X, Nimigean, C. | | Deposit date: | 2021-08-13 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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7RTJ
 | | SthK Y26F Activated State | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | Authors: | Gao, X, Nimigean, C. | | Deposit date: | 2021-08-13 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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7RSH
 | | SthK Y26F Closed State | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | | Authors: | Gao, X, Nimigean, C. | | Deposit date: | 2021-08-11 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.
Nat Commun, 13, 2022
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8FZ7
 | | TpeA bound closed MthK-A88F mutant in nanodisc | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(tripentyl-$l^{4}-azanyl)pentane, Calcium-gated potassium channel MthK, ... | | Authors: | Agarwal, S, Nimigean, C.M. | | Deposit date: | 2023-01-27 | | Release date: | 2023-10-11 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Nat.Chem.Biol., 20, 2024
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1K4D
 | | Potassium Channel KcsA-Fab complex in low concentration of K+ | | Descriptor: | DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... | | Authors: | Zhou, Y, Morais-Cabral, J.H, Kaufman, A, MacKinnon, R. | | Deposit date: | 2001-10-07 | | Release date: | 2001-11-14 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
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8HK6
 | | potassium channel | | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | | Authors: | Jiang, D.H, Zhang, J.T. | | Deposit date: | 2022-11-25 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HKK
 | | ion channel | | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | | Authors: | Jiang, D.H, Zhang, J.T. | | Deposit date: | 2022-11-27 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HKF
 | | ion channel | | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION | | Authors: | Jiang, D.H, Zhang, Z.T. | | Deposit date: | 2022-11-25 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HKM
 | | ion channel | | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, ZINC ION, ... | | Authors: | Jiang, D.H, Zhang, J.T. | | Deposit date: | 2022-11-27 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HKQ
 | | ion channel | | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | | Authors: | Jiang, D.H, Zhang, J.T. | | Deposit date: | 2022-11-27 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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8HIR
 | | potassium channels | | Descriptor: | POTASSIUM ION, Potassium channel subfamily T member 1, SODIUM ION, ... | | Authors: | Jiang, D.H, Zhang, J.T. | | Deposit date: | 2022-11-21 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Structural basis of human Slo2.2 channel gating and modulation.
Cell Rep, 42, 2023
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1LNQ
 | | CRYSTAL STRUCTURE OF MTHK AT 3.3 A | | Descriptor: | CALCIUM ION, POTASSIUM CHANNEL RELATED PROTEIN | | Authors: | Jiang, Y, Lee, A, Chen, J, Cadene, M, Chait, B.T, Mackinnon, R. | | Deposit date: | 2002-05-03 | | Release date: | 2002-06-19 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
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2QKS
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4GX0
 | | Crystal structure of the GsuK L97D mutant | | Descriptor: | CALCIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
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4GX5
 | | GsuK Channel | | Descriptor: | CALCIUM ION, POTASSIUM ION, TrkA domain protein, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
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