3UFM
 
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3UF7
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5NN7
 | | KSHV uracil-DNA glycosylase, apo form | | Descriptor: | Uracil-DNA glycosylase | | Authors: | Earl, C, Bagneris, C, Cole, A.R, Barrett, T, Savva, R. | | Deposit date: | 2017-04-08 | | Release date: | 2018-03-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Nucleic Acids Res., 46, 2018
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5NNU
 | | KSHV uracil-DNA glycosylase, product complex with dsDNA exhibiting duplex nucleotide flipping | | Descriptor: | DNA, DNA containing an abasic site, Uracil-DNA glycosylase | | Authors: | Earl, C, Bagneris, C, Barrett, T, Savva, R. | | Deposit date: | 2017-04-10 | | Release date: | 2018-03-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Nucleic Acids Res., 46, 2018
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4JGC
 | | Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC) | | Descriptor: | 4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, ... | | Authors: | Hashimoto, H, Zhang, X, Cheng, X. | | Deposit date: | 2013-02-28 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.582 Å) | | Cite: | Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH.
Dna Repair, 12, 2013
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6U17
 | | Human thymine DNA glycosylase bound to DNA with 2'-F-5-carboxyl-dC substrate analog | | Descriptor: | ACETATE ION, DNA (28-MER), DNA (30-MER), ... | | Authors: | Pidugu, L.S, Pozharski, E, Drohat, A.C. | | Deposit date: | 2019-08-15 | | Release date: | 2019-11-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
J.Am.Chem.Soc., 141, 2019
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5NNH
 | | KSHV uracil-DNA glycosylase, apo form | | Descriptor: | SULFATE ION, Uracil-DNA glycosylase | | Authors: | Earl, C, Bagneris, C, Cole, A.R, Barrett, T, Savva, R. | | Deposit date: | 2017-04-09 | | Release date: | 2018-03-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Nucleic Acids Res., 46, 2018
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6U15
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6U16
 | | Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate | | Descriptor: | 1,2-ETHANEDIOL, DNA (28-MER), G/T mismatch-specific thymine DNA glycosylase | | Authors: | Pidugu, L.S, Pozharski, E, Drohat, A.C. | | Deposit date: | 2019-08-15 | | Release date: | 2019-11-20 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
J.Am.Chem.Soc., 141, 2019
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5X55
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6L6S
 | | The structure of the UdgX mutant H109E crosslinked to single-stranded DNA | | Descriptor: | DNA (5'-D(P*TP*GP*(ORP)P*AP*GP*GP*CP*AP*TP*GP*C)-3'), IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein | | Authors: | Xie, W, Tu, J, Zeng, H. | | Deposit date: | 2019-10-29 | | Release date: | 2020-11-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.06425953 Å) | | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.
DNA Repair (Amst), 97, 2021
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6L5B
 | | The structure of the UdgX mutant H109E at a post-excision state | | Descriptor: | IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | | Authors: | Xie, W, Tu, J, Zeng, H. | | Deposit date: | 2019-10-22 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.00004983 Å) | | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.
DNA Repair (Amst), 97, 2021
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6L5A
 | | The structure of the UdgX mutant H109E at a pre-excision state | | Descriptor: | GLYCEROL, IRON/SULFUR CLUSTER, Uracil DNA glycosylase superfamily protein | | Authors: | Xie, W, Tu, J, Zeng, H. | | Deposit date: | 2019-10-22 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.80007327 Å) | | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability.
DNA Repair (Amst), 97, 2021
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2JHQ
 | | Crystal structure of Uracil DNA-glycosylase from Vibrio cholerae | | Descriptor: | CHLORIDE ION, URACIL DNA-GLYCOSYLASE | | Authors: | Raeder, I.L.U, Moe, E, Willassen, N.P, Smalas, A.O, Leiros, I. | | Deposit date: | 2007-02-23 | | Release date: | 2008-06-03 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of Uracil-DNA N-Glycosylase (Ung) from Vibrio Cholerae. Mapping Temperature Adaptation Through Structural and Mutational Analysis.
Acta Crystallogr.,Sect.F, 66, 2010
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2HXM
 | | Complex of UNG2 and a small Molecule synthetic Inhibitor | | Descriptor: | 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID, Uracil-DNA glycosylase | | Authors: | Bianchet, M.A, Krosky, D.J, Ghung, S, Seiple, L, Amzel, L.M, Stivers, J.T. | | Deposit date: | 2006-08-03 | | Release date: | 2006-12-05 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Mimicking damaged DNA with a small molecule inhibitor of human UNG2.
Nucleic Acids Res., 34, 2006
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6AIL
 | | CRYSTAL STRUCTURE AT 1.3 ANGSTROMS RESOLUTION OF A NOVEL UDG, UdgX, FROM Mycobacterium smegmatis | | Descriptor: | IRON/SULFUR CLUSTER, Uracil DNA glycosylase X | | Authors: | Ahn, W.C, Aroli, S, Varshney, V, Woo, E.J. | | Deposit date: | 2018-08-24 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.335 Å) | | Cite: | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
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6AJO
 | | Complex form of Uracil DNA glycosylase X and uracil-DNA. | | Descriptor: | DNA (5'-D(P*(ORP)P*TP*T)-3'), IRON/SULFUR CLUSTER, PHOSPHATE ION, ... | | Authors: | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | | Deposit date: | 2018-08-28 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.269 Å) | | Cite: | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
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6AJR
 | | Complex form of Uracil DNA glycosylase X and uracil | | Descriptor: | IRON/SULFUR CLUSTER, URACIL, Uracil DNA glycosylase superfamily protein | | Authors: | Ahn, W.C, Aroli, S, Varshney, U, Woo, E.J. | | Deposit date: | 2018-08-28 | | Release date: | 2019-05-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.341 Å) | | Cite: | Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision.
Nat.Chem.Biol., 15, 2019
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2L3F
 | | Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76 | | Descriptor: | Uncharacterized protein | | Authors: | Aramini, J.M, Hamilton, K, Ciccosanti, C.T, Wang, H, Lee, H.W, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2010-09-13 | | Release date: | 2010-10-20 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of a putative Uracil DNA glycosylase from Methanosarcina acetivorans, Northeast Structural Genomics Consortium Target MvR76
To be Published
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6IOD
 | | The structure of UdgX in complex with single-stranded DNA | | Descriptor: | DNA, IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein | | Authors: | Xie, W, Tu, J. | | Deposit date: | 2018-10-29 | | Release date: | 2019-07-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation.
Nat.Chem.Biol., 15, 2019
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1L9G
 | | CRYSTAL STRUCTURE OF URACIL-DNA GLYCOSYLASE FROM T. MARITIMA | | Descriptor: | Conserved hypothetical protein, IRON/SULFUR CLUSTER, SULFATE ION | | Authors: | Rajashankar, K.R, Dodatko, T, Thirumuruhan, R.A, Sandigursky, M, Bresnik, A, Chance, M.R, Franklin, W.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2002-03-22 | | Release date: | 2003-05-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of uracil-DNA glycosylase from T. Maritima
To be Published
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1LAU
 | | URACIL-DNA GLYCOSYLASE | | Descriptor: | DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-)) | | Authors: | Pearl, L.H, Savva, R. | | Deposit date: | 1996-01-03 | | Release date: | 1996-06-10 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
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6IO9
 | | The structure of apo-UdgX | | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, SULFATE ION | | Authors: | Xie, W, Tu, J. | | Deposit date: | 2018-10-29 | | Release date: | 2019-07-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation.
Nat.Chem.Biol., 15, 2019
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6IOB
 | | The structure of the H109A mutant of UdgX in complex with uracil | | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, URACIL | | Authors: | Xie, W, Tu, J. | | Deposit date: | 2018-10-29 | | Release date: | 2019-07-24 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation.
Nat.Chem.Biol., 15, 2019
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6IOA
 | | The structure of UdgX in complex with uracil | | Descriptor: | IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein, SULFATE ION, ... | | Authors: | Xie, W, Tu, J. | | Deposit date: | 2018-10-29 | | Release date: | 2019-07-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation.
Nat.Chem.Biol., 15, 2019
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