6U16

Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate

Summary for 6U16

• Entry DOI: 10.2210/pdb6u16/pdb
• Descriptor: G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: protein-dna complex, hydrolase-dna complex, dna binding protein, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 43275.28

Authors

Pidugu, L.S.,Pozharski, E.,Drohat, A.C. (deposition date: 2019-08-15, release date: 2019-11-20, Last modification date: 2023-11-15)

• Primary citation: Pidugu, L.S.,Dai, Q.,Malik, S.S.,Pozharski, E.,Drohat, A.C.; Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.; J.Am.Chem.Soc., 141:18851-18861, 2019; PubMed: 31693361; DOI: 10.1021/jacs.9b10376

Experimental method

X-RAY DIFFRACTION (1.6 Å)