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6U16

Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000700molecular_functionmismatch base pair DNA N-glycosylase activity
A0006285biological_processbase-excision repair, AP site formation
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue EDO A 401
ChainResidue
AARG110
AMET144
AARG281
AHOH538
CDG14

site_idAC2
Number of Residues4
Detailsbinding site for residue EDO A 402
ChainResidue
ALYS122
ATYR147
AHOH510
CDA15

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS103
ALYS248

Catalytic Information from CSA
site_idMCSA1
Number of Residues2
DetailsM-CSA 834
ChainResidueDetails
AALA140electrostatic interaction
AHIS151proton acceptor, proton donor

226707

PDB entries from 2024-10-30

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