6U16

Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000700	molecular_function	mismatch base pair DNA N-glycosylase activity
A	0006285	biological_process	base-excision repair, AP site formation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 401

Chain	Residue
A	ARG110
A	MET144
A	ARG281
A	HOH538
C	DG14

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site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 402

Chain	Residue
A	LYS122
A	TYR147
A	HOH510
C	DA15

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 834

Chain	Residue	Details
A	ALA140	electrostatic interaction
A	HIS151	proton acceptor, proton donor

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