7TX9
 
 | | Human Synaptotagmin-1 C2B Y312F Ca2+ bound | | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Dominguez, M.J, Karmakar, S, Fuson, K.L, Sutton, R.B. | | Deposit date: | 2022-02-08 | | Release date: | 2023-03-29 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.34 Å) | | Cite: | Human Synaptotagmin-1 C2B Y312F Ca2+ bound
To Be Published
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4Y1S
 | | Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes | | Descriptor: | CALCIUM ION, Perforin-1 | | Authors: | Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S. | | Deposit date: | 2015-02-09 | | Release date: | 2015-09-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.611 Å) | | Cite: | Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
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6TZ3
 | | Crystal Structure of Human Synaptotagmin 1 C2B without Ca2+ | | Descriptor: | SULFATE ION, Synaptotagmin-1 | | Authors: | Dominguez, M.J, Karmakar, S, Meyer, A.G, Sutton, R.B. | | Deposit date: | 2019-08-09 | | Release date: | 2020-05-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Neuron, 107, 2020
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6U41
 | | 1.7 angstrom structure of a pathogenic human Syt 1 C2B (D304G) | | Descriptor: | SULFATE ION, Synaptotagmin-1 | | Authors: | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | | Deposit date: | 2019-08-22 | | Release date: | 2020-05-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Neuron, 107, 2020
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6U4U
 | | 1.3 A structure of a pathogenic human Syt 1 C2B (I368T) | | Descriptor: | SULFATE ION, Synaptotagmin-1 | | Authors: | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | | Deposit date: | 2019-08-26 | | Release date: | 2020-05-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Neuron, 107, 2020
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7JOF
 | | Calcium-bound C2A Domain from Human Dysferlin | | Descriptor: | CALCIUM ION, Isoform 6 of Dysferlin | | Authors: | Tadayon, R, Wang, Y, Santamaria, L, Mercier, P, Forristal, C, Shaw, G.S. | | Deposit date: | 2020-08-06 | | Release date: | 2021-06-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Biochem.J., 478, 2021
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4Y1T
 | | Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes | | Descriptor: | CALCIUM ION, Perforin-1 | | Authors: | Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S. | | Deposit date: | 2015-02-09 | | Release date: | 2015-09-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.666 Å) | | Cite: | Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
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7K6B
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7KRB
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3RDJ
 | | Rat PKC C2 domain Apo | | Descriptor: | Protein kinase C alpha type | | Authors: | Li, P. | | Deposit date: | 2011-04-01 | | Release date: | 2011-09-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Pb2+ as modulator of protein-membrane interactions.
J.Am.Chem.Soc., 133, 2011
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3HN8
 | | Crystal structure of synaptotagmin | | Descriptor: | CALCIUM ION, Synaptotagmin-3, ZINC ION | | Authors: | Strop, P, Vrljic, M, Ernst, J, Brunger, A.T. | | Deposit date: | 2009-05-30 | | Release date: | 2010-02-23 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.
Nat.Struct.Mol.Biol., 17, 2010
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5A52
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3TWY
 | | RAT PKC C2 DOMAIN BOUND TO PB | | Descriptor: | LEAD (II) ION, Protein kinase C alpha type, SULFATE ION | | Authors: | Li, P. | | Deposit date: | 2011-09-22 | | Release date: | 2011-11-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Pb2+ as Modulator of Protein-Membrane Interactions.
J.Am.Chem.Soc., 133, 2011
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3L9B
 | | Crystal Structure of Rat Otoferlin C2A | | Descriptor: | MAGNESIUM ION, Otoferlin | | Authors: | Helfmann, S, Neumann, P. | | Deposit date: | 2010-01-04 | | Release date: | 2011-01-19 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | The crystal structure of the C2A domain of otoferlin reveals an unconventional top loop region.
J.Mol.Biol., 406, 2011
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3RPB
 | | THE C2B-DOMAIN OF RABPHILIN: STRUCTURAL VARIATIONS IN A JANUS-FACED DOMAIN | | Descriptor: | RABPHILIN 3-A | | Authors: | Ubach, J, Garcia, J, Nittler, M.P, Sudhof, T.C, Rizo, J. | | Deposit date: | 1999-04-19 | | Release date: | 1999-12-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of the Janus-faced C2B domain of rabphilin.
Nat.Cell Biol., 1, 1999
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2YOA
 | | Synaptotagmin-1 C2B domain with phosphoserine | | Descriptor: | CALCIUM ION, PHOSPHOSERINE, SYNAPTOTAGMIN-1, ... | | Authors: | Honigmann, A, van den Bogaart, G, Iraheta, E, Risselada, H.J, Milovanovic, D, Mueller, V, Muellar, S, Diederichsen, U, Fasshauer, D, Grubmuller, H, Hell, S.W, Eggeling, C, Kuhnel, K, Jahn, R. | | Deposit date: | 2012-10-22 | | Release date: | 2013-03-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Phosphatidylinositol 4,5-Bisphosphate Clusters Act as Molecular Beacons for Vesicle Recruitment
Nat.Struct.Mol.Biol., 20, 2013
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7A1R
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2Z0U
 | | Crystal structure of C2 domain of KIBRA protein | | Descriptor: | WW domain-containing protein 1 | | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-05-07 | | Release date: | 2008-05-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of C2 domain of KIBRA protein
To be Published
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7ATP
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7AS6
 | | 2.0 angstrom structure of plant Extended Synaptotagmin 1, C2A domain | | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | | Authors: | Benavente, J.L, Albert, A. | | Deposit date: | 2020-10-27 | | Release date: | 2021-08-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites.
Life Sci Alliance, 4, 2021
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4IQH
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4ICX
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4IHB
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4ICW
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1GMI
 | | Structure of the c2 domain from novel protein kinase C epsilon | | Descriptor: | MAGNESIUM ION, PROTEIN KINASE C, EPSILON TYPE | | Authors: | Ochoa, W.F, Garcia-Garcia, J, Fita, I, Corbalan-Garcia, S, Verdaguer, N, Gomez-Fernandez, J.C. | | Deposit date: | 2001-09-14 | | Release date: | 2001-10-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the C2 Domain from Novel Protein Kinase Cepsilon. A Membrane Binding Model for Ca(2+ )-Independent C2 Domains
J.Mol.Biol., 311, 2001
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