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PDB: 303 results

7XUG
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BU of 7xug by Molmil
cryo-EM structure of HK022 putRNA-less E.coli RNA polymerase elongation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Hwang, S, Kang, J.Y.
Deposit date:2022-05-18
Release date:2022-08-10
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.
Nat Commun, 13, 2022
7KHE
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BU of 7khe by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp
Descriptor: CHAPSO, DNA (46-MER), DNA (54-MER), ...
Authors:Shin, Y, Qayyum, M.Z, Murakami, K.S.
Deposit date:2020-10-21
Release date:2020-12-09
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7YP9
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BU of 7yp9 by Molmil
Cryo-EM structure of Escherichia coli paused complex of transcription termination (TTC-pause)
Descriptor: DNA (31-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:You, L.L, Zhang, Y.
Deposit date:2022-08-03
Release date:2022-11-16
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis for intrinsic transcription termination.
Nature, 613, 2023
7CHW
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Cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo)
Descriptor: DNA (63-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lin, W, Feng, Y.
Deposit date:2020-07-06
Release date:2020-08-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis for transcription inhibition by E. coli SspA
Nucleic Acids Res., 2020
6X4Y
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BU of 6x4y by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - IV state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-24
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
6X43
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BU of 6x43 by Molmil
Mfd-bound E.coli RNA polymerase elongation complex - II state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A.
Deposit date:2020-05-22
Release date:2021-02-03
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for transcription complex disruption by the Mfd translocase.
Elife, 10, 2021
5IPL
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BU of 5ipl by Molmil
SigmaS-transcription initiation complex with 4-nt nascent RNA
Descriptor: DIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Zuo, Y, Steitz, T.A.
Deposit date:2016-03-09
Release date:2016-03-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5UAQ
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BU of 5uaq by Molmil
Escherichia coli RNA polymerase RpoB H526Y mutant
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
Deposit date:2016-12-19
Release date:2017-01-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
6BYU
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BU of 6byu by Molmil
X-ray crystal structure of Escherichia coli RNA polymerase (RpoB-H526Y) and ppApp complex
Descriptor: (5R)-5-(6-amino-9H-purin-9-yl)-2-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-4-oxo-4,5-dihydrofuran-3-yl trihydrogen diphosphate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S, Molodtsov, V.
Deposit date:2017-12-21
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro.
Biochim. Biophys. Acta, 1861, 2018
6FLQ
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BU of 6flq by Molmil
CryoEM structure of E.coli RNA polymerase paused elongation complex bound to NusA
Descriptor: DNA (31-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Guo, X, Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-21
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6RH3
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BU of 6rh3 by Molmil
Cryo-EM structure of E. coli RNA polymerase elongation complex bound to CTP substrate
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Abdelkareem, M, Saint-Andre, C, Takacs, M, Papai, G, Crucifix, C, Guo, X, Ortiz, J, Weixlbaumer, A.
Deposit date:2019-04-18
Release date:2019-07-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation.
Mol.Cell, 75, 2019
7XUI
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BU of 7xui by Molmil
Cryo-EM structure of sigma70 bound HK022 putRNA-associated E.coli RNA polymerase elongation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Hwang, S, Kang, J.Y.
Deposit date:2022-05-18
Release date:2022-08-10
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.
Nat Commun, 13, 2022
7KHI
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BU of 7khi by Molmil
Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp
Descriptor: CHAPSO, DNA (28-MER), DNA (36-MER), ...
Authors:Shin, Y, Qayyum, M.Z, Murakami, K.S.
Deposit date:2020-10-21
Release date:2020-10-28
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
7DY6
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BU of 7dy6 by Molmil
A refined cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) with SspA
Descriptor: DNA (63-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lin, W.
Deposit date:2021-01-20
Release date:2021-11-17
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:A unique binding between SspA and RNAP beta' NTH across low-GC Gram-negative bacteria facilitates SspA-mediated transcription regulation.
Biochem.Biophys.Res.Commun., 583, 2021
6N60
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BU of 6n60 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Microcin J25 (MccJ25)
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
Deposit date:2018-11-23
Release date:2019-01-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.68 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
7C97
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BU of 7c97 by Molmil
Cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) with SspA
Descriptor: DNA (63-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lin, W, Feng, Y.
Deposit date:2020-06-05
Release date:2020-08-12
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structural basis for transcription inhibition by E. coli SspA
Nucleic Acids Res., 2020
4KN7
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BU of 4kn7 by Molmil
X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c
Descriptor: Benzoxazinorifamycin-2c, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Murakami, K.S.
Deposit date:2013-05-08
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.686 Å)
Cite:X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56, 2013
6LDI
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BU of 6ldi by Molmil
The cryo-EM structure of E. coli CueR transcription activation complex
Descriptor: DNA (50-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Fang, C.L, Zhang, Y.
Deposit date:2019-11-21
Release date:2020-09-30
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:CueR activates transcription through a DNA distortion mechanism.
Nat.Chem.Biol., 17, 2021
6ALG
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BU of 6alg by Molmil
CryoEM structure of HK022 Nun - E.coli RNA polymerase elongation complex
Descriptor: DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Kang, J.Y, Darst, S.A.
Deposit date:2017-08-07
Release date:2017-08-16
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of transcription arrest by coliphage HK022 Nun in anEscherichia coliRNA polymerase elongation complex.
Elife, 6, 2017
7MKE
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BU of 7mke by Molmil
Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2)
Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Saecker, R.M, Darst, S.A, Chen, J.
Deposit date:2021-04-23
Release date:2021-09-29
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
6RIN
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BU of 6rin by Molmil
Cryo-EM structure of E. coli RNA polymerase backtracked elongation complex bound to GreB transcription factor
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Abdelkareem, M, Saint-Andre, C, Takacs, M, Papai, G, Crucifix, C, Guo, X, Ortiz, J, Weixlbaumer, A.
Deposit date:2019-04-24
Release date:2019-07-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation.
Mol.Cell, 75, 2019
8EHA
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BU of 8eha by Molmil
Cryo-EM structure of his-elemental paused elongation complex with a folded TL and a rotated RH-FL (out)
Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Kang, J.Y, Chen, J, Llewellyn, E, Landick, R, Darst, S.A.
Deposit date:2022-09-14
Release date:2023-03-01
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options.
Proc.Natl.Acad.Sci.USA, 120, 2023
6N57
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BU of 6n57 by Molmil
Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I
Descriptor: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A.
Deposit date:2018-11-21
Release date:2020-02-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Elife, 8, 2019
6R9G
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BU of 6r9g by Molmil
Structural basis of transcription inhibition by the DNA mimic Ocr protein of bacteriophage T7
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Ye, F.Z, Zhang, X.D.
Deposit date:2019-04-03
Release date:2020-02-26
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7.
Elife, 9, 2020
6PSW
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BU of 6psw by Molmil
Escherichia coli RNA polymerase promoter unwinding intermediate (TRPo) with TraR and rpsT P2 promoter
Descriptor: CHAPSO, DNA (85-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A.
Deposit date:2019-07-13
Release date:2020-03-25
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Stepwise Promoter Melting by Bacterial RNA Polymerase.
Mol.Cell, 78, 2020

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PDB entries from 2024-07-31

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