8XZH
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![BU of 8xzh by Molmil](/molmil-images/mine/8xzh) | Cryo-EM structure of the MM07-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
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3NR9
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![BU of 3nr9 by Molmil](/molmil-images/mine/3nr9) | Structure of human CDC2-like kinase 2 (CLK2) | 分子名称: | (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one, Dual specificity protein kinase CLK2 | 著者 | Chaikuad, A, Savitsky, P, Krojer, T, Muniz, J.R.C, Filippakopoulos, P, Rellos, P, Keates, T, Fedorov, O, Pike, A.C.W, Eswaran, J, Berridge, G, Phillips, C, Zhang, Y, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2010-06-30 | 公開日 | 2010-08-25 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structure of human CDC2-like kinase 2 (CLK2) To be Published
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8GTP
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![BU of 8gtp by Molmil](/molmil-images/mine/8gtp) | cryo-EM structure of Omicron BA.5 S protein in complex with XGv289 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Xia, X.Y, Zhang, Y.Y, Chi, X.M, Huang, B.D, Wu, L.S, Zhou, Q. | 登録日 | 2022-09-08 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants. Cell Discov, 9, 2023
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8GTQ
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![BU of 8gtq by Molmil](/molmil-images/mine/8gtq) | cryo-EM structure of Omicron BA.5 S protein in complex with S2L20 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Xia, X.Y, Zhang, Y.Y, Chi, X.M, Huang, B.D, Wu, L.S, Zhou, Q. | 登録日 | 2022-09-08 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants. Cell Discov, 9, 2023
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4CKH
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![BU of 4ckh by Molmil](/molmil-images/mine/4ckh) | Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy | 分子名称: | ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 | 著者 | Pang, X.Y, Fan, J, Zhang, Y, Zhang, K, Gao, B.Q, Ma, J, Li, J, Deng, Y.C, Zhou, Q.J, Hsu, V, Sun, F. | 登録日 | 2014-01-06 | 公開日 | 2014-10-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (17 Å) | 主引用文献 | A Ph Domain in Acap1 Possesses Key Features of the Bar Domain in Promoting Membrane Curvature. Dev.Cell, 31, 2014
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5WPW
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4CKG
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![BU of 4ckg by Molmil](/molmil-images/mine/4ckg) | Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy | 分子名称: | ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 | 著者 | Pang, X.Y, Fan, J, Zhang, Y, Zhang, K, Gao, B.Q, Ma, J, Li, J, Deng, Y.C, Zhou, Q.J, Hsu, V, Sun, F. | 登録日 | 2014-01-06 | 公開日 | 2014-10-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (15 Å) | 主引用文献 | A Ph Domain in Acap1 Possesses Key Features of the Bar Domain in Promoting Membrane Curvature. Dev.Cell, 31, 2014
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1ZCN
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![BU of 1zcn by Molmil](/molmil-images/mine/1zcn) | human Pin1 Ng mutant | 分子名称: | PENTAETHYLENE GLYCOL, PHOSPHATE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Jager, M, Zhang, Y, Nguyen, H, Dendel, G, Bowman, M.E, Gruebele, M, Noel, J.P, Kelly, J.W. | 登録日 | 2005-04-12 | 公開日 | 2006-06-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-function-folding relationship in a WW domain. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1ZYW
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![BU of 1zyw by Molmil](/molmil-images/mine/1zyw) | Crystal Structure Of Mutant K8DP9SR58KP60G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | 分子名称: | ACETATE ION, Alpha-like neurotoxin BmK-I, SULFATE ION | 著者 | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | 登録日 | 2005-06-13 | 公開日 | 2006-05-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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5X57
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![BU of 5x57 by Molmil](/molmil-images/mine/5x57) | Structure of GAR domain of ACF7 | 分子名称: | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, NICKEL (II) ION | 著者 | Yang, F, Wang, T, Zhang, Y, Wu, X.Y. | 登録日 | 2017-02-15 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun, 8, 2017
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1ZUT
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![BU of 1zut by Molmil](/molmil-images/mine/1zut) | Crystal Structure Of Mutant K8DP9SR58K Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | 分子名称: | Alpha-like neurotoxin BmK-I, SULFATE ION | 著者 | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | 登録日 | 2005-06-01 | 公開日 | 2006-05-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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1ZXC
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![BU of 1zxc by Molmil](/molmil-images/mine/1zxc) | Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor | 分子名称: | (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ADAM 17, ZINC ION | 著者 | Levin, J.I, Chen, J.M, Laakso, L.M, Du, M, Schmid, J, Xu, W, Cummons, T, Xu, J, Zhang, Y, Jin, G, Cowling, R, Barone, D, Skotnicki, J.S. | 登録日 | 2005-06-07 | 公開日 | 2005-09-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates. Bioorg.Med.Chem.Lett., 15, 2005
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1ZYV
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![BU of 1zyv by Molmil](/molmil-images/mine/1zyv) | Crystal Structure Of Mutant K8DP9SR58KV59G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | 分子名称: | Alpha-like neurotoxin BmK-I | 著者 | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | 登録日 | 2005-06-12 | 公開日 | 2006-05-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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1ZU3
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![BU of 1zu3 by Molmil](/molmil-images/mine/1zu3) | Crystal Structure Of Mutant K8A Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | 分子名称: | Alpha-like neurotoxin BmK-I | 著者 | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | 登録日 | 2005-05-30 | 公開日 | 2006-05-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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1ZVE
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![BU of 1zve by Molmil](/molmil-images/mine/1zve) | Crystal Structure Of Mutant K8G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | 分子名称: | ACETATE ION, Alpha-like neurotoxin BmK-I | 著者 | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | 登録日 | 2005-06-01 | 公開日 | 2006-05-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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1ZVG
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![BU of 1zvg by Molmil](/molmil-images/mine/1zvg) | Crystal Structure Of Mutant K8DP9S Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch | 分子名称: | Alpha-like neurotoxin BmK-I | 著者 | Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J. | 登録日 | 2005-06-02 | 公開日 | 2006-06-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1 J.Mol.Biol., 353, 2005
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6DUP
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![BU of 6dup by Molmil](/molmil-images/mine/6dup) | CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH COMPOUND 7 | 分子名称: | (2S)-2-({[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy}methyl)-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one, Nuclear receptor subfamily 1 group I member 2 | 著者 | Chen, X, Zhang, Y, Mclean, L.R. | 登録日 | 2018-06-21 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators. Bioorg. Med. Chem. Lett., 28, 2018
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1ZWZ
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![BU of 1zwz by Molmil](/molmil-images/mine/1zwz) | |
1Z68
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![BU of 1z68 by Molmil](/molmil-images/mine/1z68) | Crystal Structure Of Human Fibroblast Activation Protein alpha | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Aertgeerts, K, Levin, I, Shi, L, Prasad, G.S, Zhang, Y, Kraus, M.L, Salakian, S, Snell, G.P, Sridhar, V, Wijnands, R, Tennant, M.G. | 登録日 | 2005-03-21 | 公開日 | 2005-04-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. J.Biol.Chem., 280, 2005
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2AQ7
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![BU of 2aq7 by Molmil](/molmil-images/mine/2aq7) | Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli | 分子名称: | (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | 著者 | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | 登録日 | 2005-08-17 | 公開日 | 2006-01-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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2AQB
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![BU of 2aqb by Molmil](/molmil-images/mine/2aqb) | Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli | 分子名称: | (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE, 3-oxoacyl-[acyl-carrier-protein] synthase I | 著者 | Kim, P, Zhang, Y.M, Shenoy, G, Nguyen, Q.A, Boshoff, H.I, Manjunatha, U.H, Goodwin, M.B, Lonsdale, J, Price, A.C, Miller, D.J. | 登録日 | 2005-08-17 | 公開日 | 2006-01-17 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structure-Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli J.Med.Chem., 49, 2006
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2I0L
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![BU of 2i0l by Molmil](/molmil-images/mine/2i0l) | X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6. | 分子名称: | Disks large homolog 1, peptide E6 | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | 登録日 | 2006-08-10 | 公開日 | 2007-02-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein. J.Virol., 81, 2007
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2I04
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![BU of 2i04 by Molmil](/molmil-images/mine/2i04) | X-ray crystal structure of MAGI-1 PDZ1 bound to the C-terminal peptide of HPV18 E6 | 分子名称: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, SULFATE ION, ... | 著者 | Chen, X.S, Zhang, Y, Dasgupta, J, Banks, L, Thomas, M. | 登録日 | 2006-08-09 | 公開日 | 2007-02-20 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein. J.Virol., 81, 2007
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7KOK
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![BU of 7kok by Molmil](/molmil-images/mine/7kok) | The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder496 inhibitor | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[(E)-(hydroxyimino)methyl]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ACETATE ION, ... | 著者 | Osipiuk, J, Tesar, C, Endres, M, Lisnyak, V, Maki, S, Taylor, C, Zhang, Y, Zhou, Z, Azizi, S.A, Jones, K, Kathayat, R, Snyder, S.A, Dickinson, B.C, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-11-09 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder496 to be published
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2ITK
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![BU of 2itk by Molmil](/molmil-images/mine/2itk) | human Pin1 bound to D-PEPTIDE | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, D-Peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | 著者 | Noel, J.P, Zhang, Y. | 登録日 | 2006-10-19 | 公開日 | 2007-05-22 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chem.Biol., 2, 2007
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