3NFC
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4KT1
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![BU of 4kt1 by Molmil](/molmil-images/mine/4kt1) | Complex of R-spondin 1 with LGR4 extracellular domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing G-protein coupled receptor 4, ... | Authors: | Wang, X.Q, Wang, D.L. | Deposit date: | 2013-05-19 | Release date: | 2013-06-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.497 Å) | Cite: | Structural basis for R-spondin recognition by LGR4/5/6 receptors Genes Dev., 27, 2013
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1G9P
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3OD5
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![BU of 3od5 by Molmil](/molmil-images/mine/3od5) | Crystal structure of active caspase-6 bound with Ac-VEID-CHO | Descriptor: | CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO | Authors: | Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. | Deposit date: | 2010-08-11 | Release date: | 2010-10-27 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
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8VOH
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7FEE
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![BU of 7fee by Molmil](/molmil-images/mine/7fee) | Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, ... | Authors: | Wang, X, Zhao, C, Shao, Z. | Deposit date: | 2021-07-19 | Release date: | 2022-06-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nat.Chem.Biol., 18, 2022
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6X16
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![BU of 6x16 by Molmil](/molmil-images/mine/6x16) | Inward-facing state of the glutamate transporter homologue GltPh in complex with TBOA | Descriptor: | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, Glutamate transporter homologue GltPh, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Wang, X, Boudker, O. | Deposit date: | 2020-05-18 | Release date: | 2020-11-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. Elife, 9, 2020
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6X13
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![BU of 6x13 by Molmil](/molmil-images/mine/6x13) | Inward-facing sodium-bound state of the glutamate transporter homologue GltPh | Descriptor: | Glutamate transporter homologue GltPh, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Wang, X, Boudker, O. | Deposit date: | 2020-05-18 | Release date: | 2020-11-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. Elife, 9, 2020
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6X17
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6X12
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![BU of 6x12 by Molmil](/molmil-images/mine/6x12) | Inward-facing Apo-open state of the glutamate transporter homologue GltPh | Descriptor: | Glutamate transporter homologue GltPh, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Wang, X, Boudker, O. | Deposit date: | 2020-05-18 | Release date: | 2020-11-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. Elife, 9, 2020
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6X14
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![BU of 6x14 by Molmil](/molmil-images/mine/6x14) | Inward-facing state of the glutamate transporter homologue GltPh in complex with TFB-TBOA | Descriptor: | (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid, Glutamate transporter homologue GltPh, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Wang, X, Boudker, O. | Deposit date: | 2020-05-18 | Release date: | 2020-11-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters. Elife, 9, 2020
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8JUE
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![BU of 8jue by Molmil](/molmil-images/mine/8jue) | Crystal structure of glutaminase C in complex with compound 11 | Descriptor: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | Authors: | Wang, X, Hanyu, S, Tingting, D. | Deposit date: | 2023-06-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8JUB
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![BU of 8jub by Molmil](/molmil-images/mine/8jub) | Crystal structure of glutaminase C in complex with compound 27 | Descriptor: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | Authors: | Wang, X, Hanyu, S, Tingting, D. | Deposit date: | 2023-06-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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7V3L
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![BU of 7v3l by Molmil](/molmil-images/mine/7v3l) | MERS S ectodomain trimer in complex with neutralizing antibody 6516 | Descriptor: | Spike glycoprotein, antibody H, antibody L | Authors: | Wang, X, Zhao, J, Wang, Z, Wang, Y, Zeng, J. | Deposit date: | 2021-08-10 | Release date: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 6516 to be published
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4XSR
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![BU of 4xsr by Molmil](/molmil-images/mine/4xsr) | Crystal structure of Anabaena Alr3699/HepE in complex with UDP-glucose | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alr3699 protein, SULFATE ION, ... | Authors: | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2015-01-22 | Release date: | 2016-01-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology, 26, 2016
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4XSP
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![BU of 4xsp by Molmil](/molmil-images/mine/4xsp) | Crystal structure of Anabaena Alr3699/HepE in complex with UDP | Descriptor: | Alr3699 protein, GLYCEROL, URIDINE-5'-DIPHOSPHATE | Authors: | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2015-01-22 | Release date: | 2016-01-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology, 26, 2016
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4XSO
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![BU of 4xso by Molmil](/molmil-images/mine/4xso) | Crystal structure of apo-form Alr3699/HepE from Anabaena sp. strain PCC 7120 | Descriptor: | Alr3699 protein, GLYCEROL | Authors: | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2015-01-22 | Release date: | 2016-01-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology, 26, 2016
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4XSU
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![BU of 4xsu by Molmil](/molmil-images/mine/4xsu) | Crystal structure of Anabaena Alr3699/HepE in complex with UDP and glucose | Descriptor: | Alr3699 protein, GLYCEROL, SULFATE ION, ... | Authors: | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | Deposit date: | 2015-01-22 | Release date: | 2016-01-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis Glycobiology, 26, 2016
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8JNZ
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![BU of 8jnz by Molmil](/molmil-images/mine/8jnz) | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor | Descriptor: | 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | Authors: | Wang, X.Y, Wang, C.Y, Zhou, J, Xu, B.L. | Deposit date: | 2023-06-06 | Release date: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor To Be Published
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7V5K
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![BU of 7v5k by Molmil](/molmil-images/mine/7v5k) | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-17 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) to be published
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7V5J
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![BU of 7v5j by Molmil](/molmil-images/mine/7v5j) | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-17 | Release date: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) to be published
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7V6N
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![BU of 7v6n by Molmil](/molmil-images/mine/7v6n) | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 | Descriptor: | 111 H, 111 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-20 | Release date: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 to be published
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7V6O
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![BU of 7v6o by Molmil](/molmil-images/mine/7v6o) | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) | Descriptor: | 111 H, 111 L, Spike glycoprotein | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | Deposit date: | 2021-08-20 | Release date: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (4.56 Å) | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) to be published
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3O4O
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![BU of 3o4o by Molmil](/molmil-images/mine/3o4o) | Crystal structure of an Interleukin-1 receptor complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, ... | Authors: | Wang, X.Q, Wang, D.L, Zhang, S.Y, Li, L, Liu, X, Mei, K.R. | Deposit date: | 2010-07-27 | Release date: | 2010-09-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural insights into the assembly and activation of IL-1beta with its receptors Nat.Immunol., 11, 2010
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3TKR
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![BU of 3tkr by Molmil](/molmil-images/mine/3tkr) | Crystal structure of full-length human peroxiredoxin 4 with T118E mutation | Descriptor: | Peroxiredoxin-4 | Authors: | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | Deposit date: | 2011-08-28 | Release date: | 2011-10-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4 Biochem.J., 2011
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