3NFC
 
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4KT1
 | | Complex of R-spondin 1 with LGR4 extracellular domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing G-protein coupled receptor 4, ... | | 著者 | Wang, X.Q, Wang, D.L. | | 登録日 | 2013-05-19 | | 公開日 | 2013-06-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | Structural basis for R-spondin recognition by LGR4/5/6 receptors
Genes Dev., 27, 2013
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1G9P
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3OD5
 | | Crystal structure of active caspase-6 bound with Ac-VEID-CHO | | 分子名称: | CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO | | 著者 | Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. | | 登録日 | 2010-08-11 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
Embo Rep., 11, 2010
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8VOH
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7FEE
 | | Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, ... | | 著者 | Wang, X, Zhao, C, Shao, Z. | | 登録日 | 2021-07-19 | | 公開日 | 2022-06-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Nat.Chem.Biol., 18, 2022
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6X16
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6X13
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6X17
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6X12
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6X14
 | | Inward-facing state of the glutamate transporter homologue GltPh in complex with TFB-TBOA | | 分子名称: | (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid, Glutamate transporter homologue GltPh, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | 著者 | Wang, X, Boudker, O. | | 登録日 | 2020-05-18 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters.
Elife, 9, 2020
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8JUE
 | | Crystal structure of glutaminase C in complex with compound 11 | | 分子名称: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | | 著者 | Wang, X, Hanyu, S, Tingting, D. | | 登録日 | 2023-06-26 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8JUB
 | | Crystal structure of glutaminase C in complex with compound 27 | | 分子名称: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | | 著者 | Wang, X, Hanyu, S, Tingting, D. | | 登録日 | 2023-06-26 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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7V3L
 | | MERS S ectodomain trimer in complex with neutralizing antibody 6516 | | 分子名称: | Spike glycoprotein, antibody H, antibody L | | 著者 | Wang, X, Zhao, J, Wang, Z, Wang, Y, Zeng, J. | | 登録日 | 2021-08-10 | | 公開日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 6516
to be published
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4XSR
 | | Crystal structure of Anabaena Alr3699/HepE in complex with UDP-glucose | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alr3699 protein, SULFATE ION, ... | | 著者 | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis
Glycobiology, 26, 2016
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4XSP
 | | Crystal structure of Anabaena Alr3699/HepE in complex with UDP | | 分子名称: | Alr3699 protein, GLYCEROL, URIDINE-5'-DIPHOSPHATE | | 著者 | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis
Glycobiology, 26, 2016
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4XSO
 | | Crystal structure of apo-form Alr3699/HepE from Anabaena sp. strain PCC 7120 | | 分子名称: | Alr3699 protein, GLYCEROL | | 著者 | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis
Glycobiology, 26, 2016
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4XSU
 | | Crystal structure of Anabaena Alr3699/HepE in complex with UDP and glucose | | 分子名称: | Alr3699 protein, GLYCEROL, SULFATE ION, ... | | 著者 | Wang, X.P, Dai, Y.N, Jiang, Y.L, Cheng, W, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2015-01-22 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis
Glycobiology, 26, 2016
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8JNZ
 | | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor | | 分子名称: | 6-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | | 著者 | Wang, X.Y, Wang, C.Y, Zhou, J, Xu, B.L. | | 登録日 | 2023-06-06 | | 公開日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a pyrazolopyrimidine carboxamide inhibitor
To Be Published
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7V5K
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) | | 分子名称: | 0722 H, 0722 L, Spike glycoprotein | | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | 登録日 | 2021-08-17 | | 公開日 | 2022-08-24 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1)
to be published
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7V5J
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | | 分子名称: | 0722 H, 0722 L, Spike glycoprotein | | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | 登録日 | 2021-08-17 | | 公開日 | 2022-09-21 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2)
to be published
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7V6N
 | | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 | | 分子名称: | 111 H, 111 L, Spike glycoprotein | | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | 登録日 | 2021-08-20 | | 公開日 | 2022-09-14 | | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1
to be published
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7V6O
 | | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) | | 分子名称: | 111 H, 111 L, Spike glycoprotein | | 著者 | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | 登録日 | 2021-08-20 | | 公開日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (4.56 Å) | | 主引用文献 | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2)
to be published
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3O4O
 | | Crystal structure of an Interleukin-1 receptor complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, ... | | 著者 | Wang, X.Q, Wang, D.L, Zhang, S.Y, Li, L, Liu, X, Mei, K.R. | | 登録日 | 2010-07-27 | | 公開日 | 2010-09-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural insights into the assembly and activation of IL-1beta with its receptors
Nat.Immunol., 11, 2010
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3TKR
 | | Crystal structure of full-length human peroxiredoxin 4 with T118E mutation | | 分子名称: | Peroxiredoxin-4 | | 著者 | Wang, X, Wang, L, Wang, X, Sun, F, Wang, C.-C. | | 登録日 | 2011-08-28 | | 公開日 | 2011-10-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4
Biochem.J., 2011
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