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PDB: 1101 件
3ZP3
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INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid, ...
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZP1
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INFLUENZA VIRUS (VN1194) H5 HA with LSTc
分子名称: HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-2)-beta-D-galactopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZP2
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INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
7NHR
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Putative transmembrane protein Wzc K540M C1
分子名称: Putative transmembrane protein Wzc
著者Liu, J.W, Yang, Y, Naismith, J.H.
登録日2021-02-11
公開日2021-08-25
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献The molecular basis of regulation of bacterial capsule assembly by Wzc.
Nat Commun, 12, 2021
7SC4
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filamin complex-1
分子名称: Filamin-A/Integrin alpha-IIb light chain, form 2 chimera, SULFATE ION
著者Liu, J, Qin, J.
登録日2021-09-27
公開日2023-04-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage.
Blood, 141, 2023
6U3Y
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Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: ACETATE ION, Gamma-hemolysin subunit A, Panton-Valentine Leucocidin F, ...
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-22
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
6U49
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Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Alpha-hemolysin, SULFATE ION, fos-choline-14
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-23
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
5YJ8
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Identification of a small molecule inhibitor for the Tudor domain of TDRD3
分子名称: 5-(aminomethyl)-1,3-dimethyl-benzimidazol-2-one, SULFATE ION, Tudor domain-containing protein 3
著者Liu, J, Ruan, K.
登録日2017-10-09
公開日2018-05-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit.
FEBS J., 285, 2018
7RGW
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Crystal structure of HERC2 DOC domain
分子名称: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase HERC2
著者Liu, J, Tencer, A.H, Kutateladze, T.G.
登録日2021-07-15
公開日2022-07-20
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献The ZZ domain of HERC2 is a receptor of arginylated substrates.
Sci Rep, 12, 2022
4EWH
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Co-crystal structure of ACK1 with inhibitor
分子名称: 6-{4-[2-(dimethylamino)ethoxy]phenyl}-N-(1,3-dithiolan-2-ylmethyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Activated CDC42 kinase 1
著者Liu, J, Walker, N, Wang, Z.
登録日2012-04-27
公開日2012-09-19
最終更新日2012-10-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4MJ5
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BU of 4mj5 by Molmil
Crystal Structure of HLA-A*1101 in complex with H1-22, an influenza A(H1N1) virus epitope
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ...
著者Liu, J, Tan, S, Zhao, M, Qi, J, Gao, G.F.
登録日2013-09-03
公開日2014-10-08
最終更新日2022-08-24
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.
J.Infect.Dis., 214, 2016
4MJ6
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Crystal Structure of HLA-A*1101 in complex with H7-22, an influenza A(H7N9) virus epitope
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ...
著者Liu, J, Tan, S, Zhao, M, Qi, J, Gao, G.F.
登録日2013-09-03
公開日2014-10-08
最終更新日2022-08-24
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions.
J.Infect.Dis., 214, 2016
1P2A
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BU of 1p2a by Molmil
The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor
分子名称: 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE, Cell division protein kinase 2
著者Liu, J.-J, Dermatakis, A, Lukacs, C.M, Konzelmann, F, Chen, Y, Kammlott, U, Depinto, W, Yang, H, Yin, X, Chen, Y, Schutt, A, Simcox, M.E, Luk, K.-C.
登録日2003-04-15
公開日2003-07-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors
BIOORG.MED.CHEM., 13, 2003
6NY3
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CasX ternary complex with 30bp target DNA
分子名称: CasX, DNA Non-target strand, DNA target strand, ...
著者Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
登録日2019-02-10
公開日2019-02-27
最終更新日2019-12-25
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
6NY2
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CasX-gRNA-DNA(45bp) state I
分子名称: CasX, DNA Non-target strand, DNA target strand, ...
著者Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
登録日2019-02-10
公開日2019-02-27
最終更新日2019-12-25
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
5L0O
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IQGAP1 calponin homology domain fragment (CHDF) mutant K161C under oxidizing conditions
分子名称: Ras GTPase-activating-like protein IQGAP1
著者Liu, J, Worthylake, D.
登録日2016-07-27
公開日2016-09-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献The IQGAP1 N-Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F-Actin and Calcium-Bound Calmodulin.
Biochemistry, 55, 2016
6NY1
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CasX-gRNA-DNA(30bp) State II
分子名称: CasX, DNA Non-target strand, DNA target strand, ...
著者Liu, J.J, Orlova, N, Nogales, E, Doudna, J.A.
登録日2019-02-10
公開日2019-02-27
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature, 566, 2019
2YPG
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BU of 2ypg by Molmil
Haemagglutinin of 1968 Human H3N2 Virus in Complex with Human Receptor Analogue LSTc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Liu, J, Xiong, X, Haire, L.F, Lin, Y.P, Wharton, S.A, Martin, S.R, Coombs, P.J, Vachieri, S.G, Christodoulou, E, Walker, P.A, Skehel, J.J, Gamblin, S.J, Hay, A.J, Daniels, R.S, McCauley, J.W.
登録日2012-10-30
公開日2012-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Evolution of the Receptor Binding Properties of the Influenza A(H3N2) Hemagglutinin.
Proc.Natl.Acad.Sci.USA, 109, 2012
7LKY
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Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641
分子名称: DIMETHYL SULFOXIDE, Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ...
著者Liu, J, Kutateladze, T.G.
登録日2021-02-03
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1).
J.Med.Chem., 64, 2021
1JPX
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Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Wild type.
分子名称: gp41 envelope protein
著者Liu, J, Wang, S, LaBranche, C.C, Hoxie, J.A, Lu, M.
登録日2001-08-03
公開日2002-04-24
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
J.Biol.Chem., 277, 2002
3I6K
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Newly identified epitope from SARS-CoV membrane protein complexed with HLA-A*0201
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Liu, J, Sun, Y, Qi, J, Chu, F, Wu, H, Gao, F, Li, T, Yan, J, Gao, G.F.
登録日2009-07-07
公開日2010-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes
J Infect Dis, 202, 2010
1I5X
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HIV-1 GP41 CORE
分子名称: SULFATE ION, TRANSMEMBRANE GLYCOPROTEIN (GP41)
著者Liu, J, Lu, M.
登録日2001-03-01
公開日2002-09-10
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional analysis of interhelical interactions in the human immunodeficiency virus type 1 gp41 envelope glycoprotein by alanine-scanning mutagenesis.
J.Virol., 75, 2001
1I5Y
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HIV-1 GP41 CORE
分子名称: SULFATE ION, TRANSMEMBRANE GLYCOPROTEIN (GP41)
著者Liu, J, Lu, M.
登録日2001-03-01
公開日2002-09-10
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and functional analysis of interhelical interactions in the human immunodeficiency virus type 1 gp41 envelope glycoprotein by alanine-scanning mutagenesis.
J.Virol., 75, 2001
3I6G
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Newly identified epitope Mn2 from SARS-CoV M protein complexed withHLA-A*0201
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Liu, J.
登録日2009-07-07
公開日2010-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献The membrane protein of severe acute respiratory syndrome coronavirus acts as a dominant immunogen revealed by a clustering region of novel functionally and structurally defined cytotoxic T-lymphocyte epitopes.
J.INFECT.DIS., 202, 2010
1JCD
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Crystal Structure of a Novel Alanine-Zipper Trimer at 1.3 A Resolution, I6A,L9A,V13A,L16A,V20A,L23A,V27A,M30A,V34A,L48A,M51A mutations
分子名称: MAJOR OUTER MEMBRANE LIPOPROTEIN
著者Liu, J, Lu, M.
登録日2001-06-08
公開日2003-06-17
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献An Alanine-Zipper Structure Determined by Long Range Intermolecular Interactions
J.Biol.Chem., 277, 2002

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