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PDB: 91 件
8VIW
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BU of 8viw by Molmil
Cryo-EM structure of heparosan synthase 2 from Pasteurella multocida with polysaccharide in the GlcNAc-T active site
分子名称: Heparosan synthase B, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE, ...
著者Krahn, J.M, Pedersen, L.C, Liu, J, Stancanelli, E, Borgnia, M, Vivarette, E.
登録日2024-01-05
公開日2024-07-24
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin
Acs Catalysis, 14, 2024
2RK1
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DHFR R67 Complexed with NADP and dihydrofolate
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, DIHYDROFOLIC ACID, Dihydrofolate reductase type 2, ...
著者Krahn, J.M, London, R.E.
登録日2007-10-16
公開日2008-06-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
2RK2
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DHFR R-67 complexed with NADP
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Krahn, J.M, London, R.E.
登録日2007-10-16
公開日2008-06-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
2RH2
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High Resolution DHFR R-67
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Dihydrofolate reductase type 2
著者Krahn, J.M, London, R.E.
登録日2007-10-05
公開日2008-06-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (0.96 Å)
主引用文献Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex
Biochemistry, 46, 2007
1ECF
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ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE
分子名称: GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
著者Krahn, J.M.
登録日1996-04-23
公開日1996-11-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli.
Protein Sci., 7, 1998
1ECG
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BU of 1ecg by Molmil
DON INACTIVATED ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE
分子名称: 5-OXO-L-NORLEUCINE, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
著者Krahn, J.M.
登録日1996-04-23
公開日1996-11-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site.
J.Biol.Chem., 271, 1996
1ECC
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BU of 1ecc by Molmil
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH MN-CPRPP AND 5-OXO-NORLEUCINE
分子名称: 1-ALPHA-PYROPHOSPHORYL-2-ALPHA,3-ALPHA-DIHYDROXY-4-BETA-CYCLOPENTANE-METHANOL-5-PHOSPHATE, 5-OXO-L-NORLEUCINE, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, ...
著者Krahn, J.M, Smith, J.L.
登録日1997-07-09
公開日1998-04-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Biochemistry, 36, 1997
1ECB
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ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH 2 GMP, 1 MG PER SUBUNIT
分子名称: GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION
著者Krahn, J.M, Smith, J.L.
登録日1997-07-15
公開日1998-04-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Biochemistry, 36, 1997
1MQ3
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Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine Template Paired with dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ...
著者Krahn, J.M, Beard, W.A, Miller, H, Grollman, A.P, Wilson, S.H.
登録日2002-09-13
公開日2003-01-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1MQ2
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Human DNA Polymerase Beta Complexed With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine and dAMP
分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3', ...
著者Krahn, J.M, Beard, W.A, Miller, H, Grollman, A.P, Wilson, S.H.
登録日2002-09-13
公開日2003-01-28
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1TVA
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BU of 1tva by Molmil
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE
分子名称: 5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
著者Krahn, J.M, Beard, W.A, Wilson, S.H.
登録日2004-06-29
公開日2004-11-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity
Structure, 12, 2004
1TV9
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BU of 1tv9 by Molmil
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE
分子名称: 5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
著者Krahn, J.M, Beard, W.M, Wilson, S.H.
登録日2004-06-29
公開日2004-11-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY
Structure, 12, 2004
4NDZ
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BU of 4ndz by Molmil
Structure of Maltose Binding Protein fusion to 2-O-Sulfotransferase with bound heptasaccharide and PAP
分子名称: ADENOSINE-3'-5'-DIPHOSPHATE, Maltose-binding periplasmic protein, Heparan sulfate 2-O-sulfotransferase 1 fusion, ...
著者Liu, C, Sheng, J, Krahn, J.M, Perera, L, Xu, Y, Hsieh, P, Liu, J, Pedersen, L.C.
登録日2013-10-28
公開日2014-03-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献Deciphering the role of 2-O-sulfotransferase in regulating heparan sulfate biosynthesis
To be Published
8V5D
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BU of 8v5d by Molmil
Human mitochondrial DNA polymerase catalytic subunit, PolG, in an APO conformation
分子名称: DNA polymerase subunit gamma-1
著者Riccio, A.A, Brannon, A.J, Krahn, J.M, Bouvette, J, Borgnia, J.M, Copeland, W.C.
登録日2023-11-30
公開日2024-07-10
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Nucleic Acids Res., 52, 2024
8VH7
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BU of 8vh7 by Molmil
Crystal structure of heparosan synthase 2 from Pasteurella multocida at 1.98 A
分子名称: 1,2-ETHANEDIOL, Heparosan synthase B, MANGANESE (II) ION, ...
著者Pedersen, L.C, Liu, J, Stancanelli, E, Krahn, J.M.
登録日2023-12-31
公開日2024-07-24
実験手法X-RAY DIFFRACTION (1.982 Å)
主引用文献Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida to Improve the Synthesis of Heparin
Acs Catalysis, 14, 2024
8V55
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BU of 8v55 by Molmil
Human mitochondrial DNA polymerase gamma bound to a replication fork in an open conformation
分子名称: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ...
著者Riccio, A.A, Krahn, J.M, Bouvette, J, Borgnia, M.J, Copeland, W.C.
登録日2023-11-30
公開日2024-07-10
最終更新日2024-07-31
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Coordinated DNA polymerization by Pol gamma and the region of LonP1 regulated proteolysis.
Nucleic Acids Res., 52, 2024
6MAT
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BU of 6mat by Molmil
Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Rix7 mutant, unknown protein
著者Lo, Y.H, Sobhany, M, Hsu, A.L, Ford, B.L, Krahn, J.M, Borgnia, M.J, Stanley, R.E.
登録日2018-08-28
公開日2019-02-06
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.
Nat Commun, 10, 2019
6OF2
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BU of 6of2 by Molmil
Precursor ribosomal RNA processing complex, State 2.
分子名称: CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
著者Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
登録日2019-03-28
公開日2019-09-11
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
1TVK
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The binding mode of epothilone A on a,b-tubulin by electron crystallography
分子名称: EPOTHILONE A, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Nettles, J.H, Li, H, Cornett, B, Krahn, J.M, Snyder, J.P, Downing, K.H.
登録日2004-06-29
公開日2004-09-14
最終更新日2023-08-23
実験手法ELECTRON CRYSTALLOGRAPHY (2.89 Å)
主引用文献The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography
Science, 305, 2004
6VCJ
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BU of 6vcj by Molmil
Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen
分子名称: (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, Dihydrofolate reductase, FOLIC ACID, ...
著者Pedersen, L.C, London, R.E, Gabel, S.A, Krahn, J.M, DeRose, E.F.
登録日2019-12-21
公開日2020-10-28
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase.
J.Med.Chem., 63, 2020
2PFP
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BU of 2pfp by Molmil
DNA Polymerase lambda in complex with DNA and dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase lambda, Downstream Primer, ...
著者Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A.
登録日2007-04-05
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
2PFQ
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BU of 2pfq by Molmil
Manganese promotes catalysis in a DNA polymerase lambda-DNA crystal
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase lambda, Downstream Primer, ...
著者Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A.
登録日2007-04-05
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
2PFN
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Na in the active site of DNA Polymerase lambda
分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA polymerase lambda, Downstream Primer, ...
著者Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A.
登録日2007-04-05
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
2PFO
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DNA Polymerase lambda in complex with DNA and dUPNPP
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA polymerase lambda, ...
著者Garcia-Diaz, M, Bebenek, K, Krahn, J.M, Pedersen, L.C, Kunkel, T.A.
登録日2007-04-05
公開日2007-05-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of the catalytic metal during polymerization by DNA polymerase lambda.
DNA Repair, 6, 2007
4XDS
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BU of 4xds by Molmil
Deoxyguanosinetriphosphate Triphosphohydrolase from Escherichia coli with Nickel
分子名称: Deoxyguanosinetriphosphate triphosphohydrolase, NICKEL (II) ION, SULFATE ION
著者Singh, D, Gawel, D, Itsko, M, Krahn, J.M, London, R.E, Schaaper, R.M.
登録日2014-12-19
公開日2015-02-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.354 Å)
主引用文献Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES.
J.Biol.Chem., 290, 2015

 

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