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PDB: 71 件
4A50
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Crystal structure of human kinesin Eg5 in complex with 2-Amino-5-(3-methylphenyl)-5,5-diphenylpentanoic acid
分子名称: (2R)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, (2S)-2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ...
著者Kaan, H.Y.K, Kozielski, F.
登録日2011-10-24
公開日2012-10-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
J.Med.Chem., 55, 2012
4BBG
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Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol
分子名称: 3-[(R)-2-azanylethylsulfanyl-(3-ethylphenyl)-phenyl-methyl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者Kaan, H.Y.K, Kozielski, F.
登録日2012-09-22
公開日2013-05-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
J.Med.Chem., 56, 2013
2X7C
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BU of 2x7c by Molmil
Crystal structure of human kinesin Eg5 in complex with (S)-enastron
分子名称: (S)-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4,7,8-HEXAHYDROQUINAZOLIN-5(6H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ...
著者Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F.
登録日2010-02-26
公開日2010-07-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2WOG
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BU of 2wog by Molmil
Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ...
著者Kaan, H.Y.K, Ulaganathan, V, Hackney, D.D, Kozielski, F.
登録日2009-07-23
公開日2010-08-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
Biochem.J., 425, 2010
2Y5W
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Crystal structure of Drosophila melanogaster kinesin-1 motor domain dimer
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN HEAVY CHAIN, MAGNESIUM ION
著者Kaan, H.Y.K, Hackney, D.D, Kozielski, F.
登録日2011-01-18
公開日2011-08-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
2Y65
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Crystal structure of Drosophila melanogaster kinesin-1 motor domain dimer-tail complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN HEAVY CHAIN, MAGNESIUM ION
著者Kaan, H.Y.K, Hackney, D.D, Kozielski, F.
登録日2011-01-19
公開日2011-08-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
2XT3
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HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION
著者Klejnot, M, Kozielski, F.
登録日2010-10-04
公開日2011-12-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.882 Å)
主引用文献Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
2X7D
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BU of 2x7d by Molmil
Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron
分子名称: (4S)-4-(3-HYDROXYPHENYL)-7,7-DIMETHYL-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ...
著者Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F.
登録日2010-02-26
公開日2010-07-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7E
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BU of 2x7e by Molmil
Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol
分子名称: (4R)-5-[(S)-(3,4-DIFLUOROPHENYL)(HYDROXY)METHYL]-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-3,4-DIHYDROPYRIMIDINE-2(1H)-THIONE, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ...
著者Kaan, H.Y.K, Ulaganathan, V, Rath, O, Laggner, C, Prokopcova, H, Dallinger, D, Kappe, C.O, Kozielski, F.
登録日2010-02-26
公開日2010-07-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
3PYM
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BU of 3pym by Molmil
Structure of GAPDH 3 from S.cerevisiae at 2.0 A resolution
分子名称: Glyceraldehyde-3-phosphate dehydrogenase 3, MESO-ERYTHRITOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Garcia-Saez, I, Kozielski, F, Job, D, Boscheron, C.
登録日2010-12-13
公開日2012-01-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献

4BEX
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BU of 4bex by Molmil
Structure of human Cofilin1
分子名称: COFILIN-1
著者Klejnot, M, Gabrielsen, M, Cameron, J, Mleczak, A, Talapatra, S.K, Kozielski, F, Pannifer, A, Olson, M.F.
登録日2013-03-12
公開日2013-08-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Analysis of the Human Cofilin1 Structure Reveals Conformational Changes Required for Actin-Binding
Acta Crystallogr.,Sect.D, 69, 2013
4AS7
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Eg5 complex 1
分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ...
著者Talapatra, S.K, Kozielski, F.
登録日2012-04-29
公開日2013-05-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A1Z
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BU of 4a1z by Molmil
Eg5-1
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, ...
著者Talapatra, S.K, Kozielski, F.
登録日2011-09-20
公開日2012-10-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4AP0
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BU of 4ap0 by Molmil
The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ...
著者Schuettelkopf, A.W, Talapatra, S.K, Kozielski, F.
登録日2012-03-30
公開日2012-09-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.594 Å)
主引用文献The Structure of the Ternary Eg5-Adp-Ispinesib Complex
Acta Crystallogr.,Sect.D, 68, 2012
4B7B
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Eg5-3
分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CALCIUM ION, ...
著者Talapatra, S.K, Kozielski, F.
登録日2012-08-17
公開日2013-07-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A28
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Eg5-2
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION
著者Talapatra, S.K, Kozielski, F.
登録日2011-09-22
公開日2012-10-31
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
4A14
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HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF7, MAGNESIUM ION
著者Klejnot, M, Kozielski, F.
登録日2011-09-14
公開日2012-01-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
4A5Y
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Intermediate state of human kinesin Eg5 in complex with Ispinesib
分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ISPINESIB MESILATE, ...
著者Kaan, H.Y.K, Kozielski, F.
登録日2011-10-29
公開日2012-11-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献"Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5.
J.Biol.Chem., 288, 2013
3ZCW
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Eg5 - New allosteric binding site
分子名称: (2E)-2-(3-fluoranyl-4-methoxy-phenyl)imino-1-[[2-(trifluoromethyl)phenyl]methyl]-3H-benzimidazole-5-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ...
著者Ulaganathan, V, Talapatra, S.K, Kozielski, F, Pannifer, A.D.
登録日2012-11-23
公開日2013-01-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.691 Å)
主引用文献Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135, 2013
4BN2
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The crystal structure of kinesin-like protein KIF15
分子名称: ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF15, MAGNESIUM ION
著者Klejnot, M, Falnikar, A, Ulaganathan, V, Cross, R, Baas, P, Kozielski, F.
登録日2013-05-13
公開日2014-01-15
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.695 Å)
主引用文献The Crystal Structure and Biochemical Characterization of Kif15: A Bifunctional Molecular Motor Involved in Bipolar Spindle Formation and Neuronal Development
Acta Crystallogr.,Sect.D, 70, 2014
4BXN
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Eg5(WT) complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, CHLORIDE ION, ...
著者Talapatra, S.K, Anthony, N.G, Mackay, S.P, Kozielski, F.
登録日2013-07-15
公開日2013-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.793 Å)
主引用文献The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56, 2013
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