5EJ4
| EcMenD-ThDP-Mn2+ complex soaked with 2-ketoglutarate for 15 min | Descriptor: | (4S)-4-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3lambda~5~-thiazol-2-yl}-4-hydroxybutanoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, FORMIC ACID, ... | Authors: | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | Deposit date: | 2015-11-01 | Release date: | 2016-06-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.773 Å) | Cite: | A Thiamine-Dependent Enzyme Utilizes an Active Tetrahedral Intermediate in Vitamin K Biosynthesis J.Am.Chem.Soc., 138, 2016
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5A6U
| Native mammalian ribosome-bound Sec61 protein-conducting channel in the 'non-inserting' state | Descriptor: | SEC61A, SEC61B, SEC61G | Authors: | Pfeffer, S, Burbaum, L, Unverdorben, P, Pech, M, Chen, Y, Zimmermann, R, Beckmann, R, Foerster, F. | Deposit date: | 2015-07-01 | Release date: | 2015-10-07 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structure of the Native Sec61 Protein-Conducting Channel. Nat.Commun., 6, 2015
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4PQG
| Crystal structure of the pneumococcal O-GlcNAc transferase GtfA in complex with UDP and GlcNAc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosyltransferase Gtf1, URIDINE-5'-DIPHOSPHATE | Authors: | Shi, W.W, Jiang, Y.L, Zhu, F, Yang, Y.H, Wu, H, Ren, Y.M, Chen, Y, Zhou, C.Z. | Deposit date: | 2014-03-03 | Release date: | 2014-06-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of a Novel O-Linked N-Acetyl-d-glucosamine (O-GlcNAc) Transferase, GtfA, Reveals Insights into the Glycosylation of Pneumococcal Serine-rich Repeat Adhesins. J.Biol.Chem., 289, 2014
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5GOP
| Crystal structure of alkaline invertase InvA from Anabaena sp. PCC 7120 complexed with sucrose | Descriptor: | Alkaline Invertase, beta-D-fructofuranose, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | Authors: | Xie, J, Cai, K, Hu, H.X, Jiang, Y.L, Yang, F, Hu, P.F, Chen, Y, Zhou, C.Z. | Deposit date: | 2016-07-28 | Release date: | 2016-11-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural Analysis of the Catalytic Mechanism and Substrate Specificity of Anabaena Alkaline Invertase InvA Reveals a Novel Glucosidase J. Biol. Chem., 291, 2016
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1RCU
| X-RAY STRUCTURE OF TM1055 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET VT76 | Descriptor: | conserved hypothetical protein VT76 | Authors: | Kuzin, A.P, Chen, Y, Edwards, A, Skarina, T, Savchenko, A, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2003-11-04 | Release date: | 2003-12-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-RAY STRUCTURE OF TM1055 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET VT76 TO BE PUBLISHED
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4GOJ
| The Crystal Structure of full length Arl3GppNHp in complex with UNC119a | Descriptor: | ADP-ribosylation factor-like protein 3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A. | Deposit date: | 2012-08-20 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. Embo J., 31, 2012
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4GOK
| The Crystal structure of Arl2GppNHp in complex with UNC119a | Descriptor: | ADP-ribosylation factor-like protein 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Ismail, S, Xiang-Chen, Y, Miertzschke, M, Vetter, I, Koerner, C, Wittinghofer, A. | Deposit date: | 2012-08-20 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. Embo J., 31, 2012
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2KDM
| NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | Descriptor: | DESIGNED PROTEIN | Authors: | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2009-01-12 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | From the Cover: A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
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2LHD
| GB98 solution structure | Descriptor: | GB98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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2LU1
| pfsub2 solution NMR structure | Descriptor: | Subtilase | Authors: | He, Y, Chen, Y, Ruan, B, O'Brochta, D, Bryan, P, Orban, J. | Deposit date: | 2012-06-06 | Release date: | 2012-10-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum. Proteins, 80, 2012
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5GVV
| Crystal structure of the glycosyltransferase GlyE in Streptococcus pneumoniae TIGR4 | Descriptor: | Glycosyl transferase family 8, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE | Authors: | Jiang, Y.L, Jin, H, Zhao, R.L, Yang, H.B, Chen, Y, Zhou, C.Z. | Deposit date: | 2016-09-07 | Release date: | 2017-03-01 | Last modified: | 2017-12-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. J. Biol. Chem., 292, 2017
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5GVW
| Crystal structure of the apo-form glycosyltransferase GlyE in Streptococcus pneumoniae TIGR4 | Descriptor: | Glycosyl transferase family 8, MANGANESE (II) ION | Authors: | Jiang, Y.L, Jin, H, Zhao, R.L, Yang, H.B, Chen, Y, Zhou, C.Z. | Deposit date: | 2016-09-07 | Release date: | 2017-03-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Defining the enzymatic pathway for polymorphic O-glycosylation of the pneumococcal serine-rich repeat protein PsrP. J. Biol. Chem., 292, 2017
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3T5I
| Structure of Fully modified farnesylated Rheb Peptide in complex with PDE6D | Descriptor: | C-terminal Farnesylated Rheb peptide CSQQGKSS(CMT), FARNESYL, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Authors: | Ismail, S.A, Chen, Y.-X, Wittinghofer, A. | Deposit date: | 2011-07-27 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat.Chem.Biol., 7, 2011
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3T5G
| Structure of fully modified farnesylated Rheb in complex with PDE6D | Descriptor: | FARNESYL, GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ismail, S.A, Chen, Y.-X, Wittinghofer, A. | Deposit date: | 2011-07-27 | Release date: | 2011-10-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat.Chem.Biol., 7, 2011
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5GOR
| Crystal structure of alkaline invertase InvA from Anabaena sp. PCC 7120 | Descriptor: | Alkaline Invertase, GLYCEROL, SULFATE ION | Authors: | Xie, J, Cai, K, Hu, H.X, Jiang, Y.L, Yang, F, Hu, P.F, Chen, Y, Zhou, C.Z. | Deposit date: | 2016-07-28 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.673 Å) | Cite: | Structural Analysis of the Catalytic Mechanism and Substrate Specificity of Anabaena Alkaline Invertase InvA Reveals a Novel Glucosidase J. Biol. Chem., 291, 2016
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8HLL
| Crystal structure of p53/BCL2 fusion complex (complex 1) | Descriptor: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | Authors: | Wei, H, Guo, M, Wang, H, Chen, Y. | Deposit date: | 2022-11-30 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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8HLM
| Crystal structure of p53/BCL2 fusion complex (complex 2) | Descriptor: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | Authors: | Guo, M, Wang, H, Wei, H, Chen, Y. | Deposit date: | 2022-11-30 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.522 Å) | Cite: | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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8HLN
| Crystal structure of p53/BCL2 fusion complex(complex3) | Descriptor: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | Authors: | Guo, M, Wei, H, Wang, H, Chen, Y. | Deposit date: | 2022-11-30 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.354 Å) | Cite: | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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2KDL
| NMR structures of GA95 and GB95, two designed proteins with 95% sequence identity but different folds and functions | Descriptor: | designed protein | Authors: | He, Y, Alexander, P, Chen, Y, Bryan, P, Orban, J. | Deposit date: | 2009-01-12 | Release date: | 2009-12-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A minimal sequence code for switching protein structure and function. Proc.Natl.Acad.Sci.USA, 106, 2009
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2LHG
| GB98-T25I solution structure | Descriptor: | GB98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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7BZV
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7CBY
| Structure of FOXG1 DNA binding domain bound to DBE2 DNA site | Descriptor: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), ... | Authors: | Dai, S.Y, Li, J, Chen, Y.H. | Deposit date: | 2020-06-15 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.646 Å) | Cite: | Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J.Mol.Biol., 432, 2020
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2LHE
| Gb98-T25I,L20A | Descriptor: | Gb98 | Authors: | He, Y, Chen, Y, Alexander, P, Bryan, P, Orban, J. | Deposit date: | 2011-08-08 | Release date: | 2012-02-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mutational tipping points for switching protein folds and functions. Structure, 20, 2012
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2OE1
| Crystal Structure of Mitochondrial Thioredoxin 3 from Saccharomyces cerevisiae (reduced form) | Descriptor: | SULFATE ION, Thioredoxin-3 | Authors: | Bao, R, Zhang, Y.R, Zhou, C.Z, Chen, Y.X. | Deposit date: | 2006-12-28 | Release date: | 2008-01-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues Biochim.Biophys.Acta, 1794, 2009
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2OE0
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