8AE2
 
 | | Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | | 登録日 | 2022-07-12 | | 公開日 | 2022-10-26 | | 最終更新日 | 2022-11-09 | | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | | 主引用文献 | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer.
Nat Commun, 13, 2022
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8BPG
 | | FcMR binding at subunit Fcu3 of IgM pentamer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | | 登録日 | 2022-11-16 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
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8BPF
 | | FcMR binding at subunit Fcu1 of IgM pentamer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | | 登録日 | 2022-11-16 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
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8BPE
 | | 8:1 binding of FcMR on IgM pentameric core | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | | 登録日 | 2022-11-16 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Structural basis for Fc receptor recognition of immunoglobulin M.
Nat.Struct.Mol.Biol., 30, 2023
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7QDO
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4D90
 | | Crystal Structure of Del-1 EGF domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Chen, Q, Schurpf, T, Springer, T, Wang, J. | | 登録日 | 2012-01-11 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
Faseb J., 26, 2012
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1R3U
 | | Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis | | 分子名称: | ACETATE ION, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION | | 著者 | Chen, Q, Liang, Y.H, Gu, X.C, Luo, M, Su, X.D. | | 登録日 | 2003-10-03 | | 公開日 | 2004-10-19 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
To be published
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6X68
 | | Cryo-EM structure of piggyBac transposase synaptic complex with hairpin DNA (SNHP) | | 分子名称: | CALCIUM ION, Transposase, ZINC ION, ... | | 著者 | Chen, Q, Hickman, A.B, Dyda, F. | | 登録日 | 2020-05-27 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | | 主引用文献 | Structural basis of seamless excision and specific targeting by piggyBac transposase
Nat Commun, 11, 2020
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6LP7
 | | Crystal structure of human DHODH in complex with inhibitor 0944 | | 分子名称: | 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2020-01-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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7S03
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4XHQ
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4X9H
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4Z91
 | | ELIC cocrystallized with isofluorane in a desensitized state | | 分子名称: | (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 1.7.6 3-bromanylpropan-1-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | 著者 | Chen, Q, Kinde, M.N, Arjunan, P, Cohen, A, Xu, Y, Tang, P. | | 登録日 | 2015-04-09 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.3915 Å) | | 主引用文献 | Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
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4Z90
 | | ELIC bound with the anesthetic isoflurane in the resting state | | 分子名称: | (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Gamma-aminobutyric-acid receptor subunit beta-1 | | 著者 | Chen, Q, Kinde, M, Arjunan, P, Cohen, A, Xu, Y, Tang, P. | | 登録日 | 2015-04-09 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5, 2015
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5TV1
 | | active arrestin-3 with inositol hexakisphosphate | | 分子名称: | Beta-arrestin-2, GLYCEROL, INOSITOL HEXAKISPHOSPHATE | | 著者 | Chen, Q, Gilbert, N.C, Perry, N.A, Vishniveteskiy, S, Gurevich, V.V, Iverson, T.M. | | 登録日 | 2016-11-07 | | 公開日 | 2017-11-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of arrestin-3 activation and signaling.
Nat Commun, 8, 2017
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5WPT
 | | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | | 著者 | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | | 登録日 | 2017-08-07 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
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5WPV
 | | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | | 著者 | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | | 登録日 | 2017-08-07 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
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5WPQ
 | | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed I conformation at 3.64 Angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | | 著者 | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | | 登録日 | 2017-08-07 | | 公開日 | 2017-10-18 | | 最終更新日 | 2023-04-05 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
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4IRE
 | | Crystal structure of GLIC with mutations at the loop C region | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ACETATE ION, OXALATE ION, ... | | 著者 | Chen, Q, Pan, J, Liang, Y.H, Xu, Y, Tang, P. | | 登録日 | 2013-01-14 | | 公開日 | 2013-04-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Signal transduction pathways in the pentameric ligand-gated ion channels.
Plos One, 8, 2013
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6J2B
 | | CTX-M-64 beta-lactamase S130T sulbactam complex | | 分子名称: | Beta-lactamase, GLYCEROL, TRANS-ENAMINE INTERMEDIATE OF SULBACTAM | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2018-12-31 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
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6J2O
 | | Crystal structure of CTX-M-64 clavulanic acid complex | | 分子名称: | (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2019-01-02 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
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6J25
 | | CTX-M-64 beta-lactamase mutant-S130T | | 分子名称: | Beta-lactamase | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2018-12-30 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
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6J2K
 | | CTX-M-64 beta-lactamase S130T clavulanic acid complex | | 分子名称: | (2E)-3-[(4-hydroxy-2-oxobutyl)amino]prop-2-enal, Beta-lactamase | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2019-01-01 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
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6JV4
 | | Crystal structure of metallo-beta-lactamase VMB-1 | | 分子名称: | CITRIC ACID, VMB-1, ZINC ION | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2019-04-15 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Genetic and Biochemical Characterization of VMB-1, a Novel Metallo-beta-Lactamase Encoded by a Conjugative, Broad-Host Range IncC Plasmid from Vibrio spp.
Adv Biosyst, 4, 2020
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5ZB7
 | | CTX-M-64 apoenzyme | | 分子名称: | Beta-lactamase | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2018-02-10 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Structural Insight into the Mechanism of Inhibitor Resistance in CTX-M-199, a CTX-M-64 Variant Carrying the S130T Substitution.
Acs Infect Dis., 6, 2020
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