8IF0
 
 | | NmeHNH-AcrIIC1 complex | | 分子名称: | Anti-CRISPR protein (AcrIIC1), CRISPR-associated endonuclease Cas9 | | 著者 | Zhu, Y.L. | | 登録日 | 2023-02-16 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Inhibition Mechanism of CRISPR-Cas9 by Anti-CRISPR Protein AcrIIC1
To Be Published
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6J9M
 | | NmeBH+AcrIIC2 | | 分子名称: | AcrIIC2, CRISPR-associated endonuclease Cas9 | | 著者 | Zhu, Y.L, Gao, A, Serganov, A, Gao, P. | | 登録日 | 2019-01-23 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.394 Å) | | 主引用文献 | Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.
Mol. Cell, 74, 2019
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6J9K
 | | Apo-AcrIIC2 | | 分子名称: | AcrIIC2, MAGNESIUM ION | | 著者 | Zhu, Y.L, Gao, A, Serganov, A, Gao, P. | | 登録日 | 2019-01-23 | | 公開日 | 2019-03-06 | | 最終更新日 | 2022-03-23 | | 実験手法 | X-RAY DIFFRACTION (2.234 Å) | | 主引用文献 | Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.
Mol. Cell, 74, 2019
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6J9L
 | | FnoBH+AcrIIC2 | | 分子名称: | AcrIIC2, HNH endonuclease family protein | | 著者 | Zhu, Y.L, Gao, A, Serganov, A, Gao, P. | | 登録日 | 2019-01-23 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.
Mol. Cell, 74, 2019
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6J9N
 | | NmeHNH+AcrIIC3 | | 分子名称: | AcrIIC3, CRISPR-associated endonuclease Cas9 | | 著者 | Zhu, Y.L, Gao, A, Serganov, A, Gao, P. | | 登録日 | 2019-01-23 | | 公開日 | 2019-03-06 | | 最終更新日 | 2022-03-23 | | 実験手法 | X-RAY DIFFRACTION (2.606 Å) | | 主引用文献 | Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins.
Mol. Cell, 74, 2019
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4I11
 | | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. | | 分子名称: | Beta-secretase 1, N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-phenylalanine, ZINC ION | | 著者 | Bowers, B, Xu, Y, Yuan, S, Probst, G.D, Hom, R.K, Chan, W, Konradi, A.W, Sham, H.L, Zhu, Y.L, Beroza, P, Pan, H, Brecht, E, Yao, N, Lougheed, J, Artis, D.R, Tam, D, Bova, M. | | 登録日 | 2012-11-19 | | 公開日 | 2013-03-06 | | 最終更新日 | 2013-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg.Med.Chem.Lett., 23, 2013
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4IFL
 | | Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes | | 分子名称: | Nrf2 peptide, kelch-like ECH-associated protein 1 | | 著者 | Pan, H, Lin, M, Yang, Y, Callaway, K, Baker, J, Diep, L, Yan, J, Tanaka, K, Zhu, Y.L, Konradi, A.W, Jobling, M, Tam, D, Ren, Z, Cheung, H, Bova, M, Riley, B.E, Yao, N, Artis, D.R. | | 登録日 | 2012-12-14 | | 公開日 | 2013-12-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
Acta Crystallogr.,Sect.D
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4IFN
 | | Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes | | 分子名称: | (1R,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, kelch-like ECH-associated protein 1 | | 著者 | Pan, H, Lin, M, Yang, Y, Callaway, K, Baker, J, Diep, L, Yan, J, Tanaka, K, Zhu, Y.L, Konradi, A.W, Jobling, M, Tam, D, Ren, Z, Cheung, H, Bova, M, Riley, B.E, Yao, N, Artis, D.R. | | 登録日 | 2012-12-14 | | 公開日 | 2013-12-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
Acta Crystallogr.,Sect.D
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4IFJ
 | | Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes | | 分子名称: | Kelch-like ECH-associated protein 1 | | 著者 | Pan, H, Lin, M, Yang, Y, Callaway, K, Baker, J, Diep, L, Yan, J, Tanaka, K, Zhu, Y.L, Konradi, A.W, Jobling, M, Tam, D, Ren, Z, Cheung, H, Bova, M, Riley, B.E, Yao, N, Artis, D.R. | | 登録日 | 2012-12-14 | | 公開日 | 2014-08-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
To be Published
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4I5M
 | | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | | 分子名称: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Serine/threonine-protein kinase PLK2 | | 著者 | Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P, Neitz, R.J, Yao, N, Lin, M, Tonn, G, Zhang, H, Bova, M.P, Ren, Z, Tam, D, Ruslim, L, Baker, J, Diep, L, Fitzgerald, K, Hoffman, J, Motter, R, Fauss, D, Tanaka, P, Dappen, M, Jagodzinski, J, Chan, W, Konradi, A.W, Latimer, L, Zhu, Y.L, Artis, D.R, Sham, H.L, Anderson, J.P, Bergeron, M. | | 登録日 | 2012-11-28 | | 公開日 | 2013-12-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain.
Chemmedchem, 8, 2013
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8GOE
 | | Structure of hSLC19A1+5-MTHF | | 分子名称: | N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, Reduced folate transporter | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-08-24 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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8GOF
 | | Structure of hSLC19A1+PMX | | 分子名称: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Reduced folate transporter | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-08-24 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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5X6D
 | | Crystal structure of PrfA-DNA binary complex | | 分子名称: | DNA (28-MER), DNA (29-MER), Listeriolysin positive regulatory factor A | | 著者 | Wang, Y, Feng, H, Zhu, Y.L, Gao, P. | | 登録日 | 2017-02-21 | | 公開日 | 2017-04-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes
Protein Cell, 8, 2017
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5X6E
 | | Crystal structure of PrfA-DNA binary complex | | 分子名称: | DNA (28-MER), DNA (29-MER), GLUTATHIONE, ... | | 著者 | Wang, Y, Feng, H, Zhu, Y.L, Gao, P. | | 登録日 | 2017-02-21 | | 公開日 | 2017-04-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Structural insights into glutathione-mediated activation of the master regulator PrfA in Listeria monocytogenes
Protein Cell, 8, 2017
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7XPZ
 | | Structure of Apo-hSLC19A1 | | 分子名称: | Reduced folate transporter | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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7XQ0
 | | Structure of hSLC19A1+3'3'-CDA | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Reduced folate transporter | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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7XQ2
 | | Structure of hSLC19A1+2'3'-cGAMP | | 分子名称: | Reduced folate transporter, cGAMP | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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7XQ1
 | | Structure of hSLC19A1+2'3'-CDAS | | 分子名称: | (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, Reduced folate transporter | | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1.
Nature, 612, 2022
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