6F90
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![BU of 6f90 by Molmil](/molmil-images/mine/6f90) | Structure of the family GH92 alpha-mannosidase BT3130 from Bacteroides thetaiotaomicron in complex with Mannoimidazole (ManI) | Descriptor: | (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, Alpha-1,2-mannosidase, putative, ... | Authors: | Thompson, A.J, Spears, R.J, Zhu, Y, Suits, M.D.L, Williams, S.J, Gilbert, H.J, Davies, G.J. | Deposit date: | 2017-12-13 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Bacteroides thetaiotaomicron generates diverse alpha-mannosidase activities through subtle evolution of a distal substrate-binding motif. Acta Crystallogr D Struct Biol, 74, 2018
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8GOF
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![BU of 8gof by Molmil](/molmil-images/mine/8gof) | Structure of hSLC19A1+PMX | Descriptor: | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Reduced folate transporter | Authors: | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | Deposit date: | 2022-08-24 | Release date: | 2022-10-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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8GOE
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![BU of 8goe by Molmil](/molmil-images/mine/8goe) | Structure of hSLC19A1+5-MTHF | Descriptor: | N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, Reduced folate transporter | Authors: | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | Deposit date: | 2022-08-24 | Release date: | 2022-10-05 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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6F92
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![BU of 6f92 by Molmil](/molmil-images/mine/6f92) | Structure of the family GH92 alpha-mannosidase BT3965 from Bacteroides thetaiotaomicron in complex with Mannoimidazole (ManI) | Descriptor: | (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Thompson, A.J, Spears, R.J, Zhu, Y, Suits, M.D.L, Williams, S.J, Gilbert, H.J, Davies, G.J. | Deposit date: | 2017-12-13 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bacteroides thetaiotaomicron generates diverse alpha-mannosidase activities through subtle evolution of a distal substrate-binding motif. Acta Crystallogr D Struct Biol, 74, 2018
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6F8Z
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![BU of 6f8z by Molmil](/molmil-images/mine/6f8z) | Structure of the family GH92 alpha-mannosidase BT3130 from Bacteroides thetaiotaomicron | Descriptor: | 1,2-ETHANEDIOL, Alpha-1,2-mannosidase, putative, ... | Authors: | Thompson, A.J, Spears, R.J, Zhu, Y, Suits, M.D.L, Williams, S.J, Gilbert, H.J, Davies, G.J. | Deposit date: | 2017-12-13 | Release date: | 2018-05-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Bacteroides thetaiotaomicron generates diverse alpha-mannosidase activities through subtle evolution of a distal substrate-binding motif. Acta Crystallogr D Struct Biol, 74, 2018
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8VQM
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![BU of 8vqm by Molmil](/molmil-images/mine/8vqm) | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6R prime | Descriptor: | (S~1~S,3R)-N-{3,5-dichloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, T.H, Zhu, Y, Wilson, I.A. | Deposit date: | 2024-01-18 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc.Natl.Acad.Sci.USA, 121, 2024
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8VQN
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![BU of 8vqn by Molmil](/molmil-images/mine/8vqn) | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule 6R | Descriptor: | (S~1~S,3R)-N-{3-chloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-(dimethylamino)pyrrolidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... | Authors: | Lin, T.H, Zhu, Y, Wilson, I.A. | Deposit date: | 2024-01-18 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry. Proc.Natl.Acad.Sci.USA, 121, 2024
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1SBW
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![BU of 1sbw by Molmil](/molmil-images/mine/1sbw) | CRYSTAL STRUCTURE OF MUNG BEAN INHIBITOR LYSINE ACTIVE FRAGMENT COMPLEX WITH BOVINE BETA-TRYPSIN AT 1.8A RESOLUTION | Descriptor: | CALCIUM ION, PROTEIN (BETA-TRYPSIN), PROTEIN (MUNG BEAN INHIBITOR LYSIN ACTIVE FRAGMENT), ... | Authors: | Huang, Q, Zhu, Y, Chi, C, Tang, Y. | Deposit date: | 1999-04-29 | Release date: | 1999-05-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of mung bean inhibitor lysine active fragment complex with bovine beta-trypsin at 1.8A resolution. J.Biomol.Struct.Dyn., 16, 1999
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1PQ0
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![BU of 1pq0 by Molmil](/molmil-images/mine/1pq0) | Crystal structure of mouse Bcl-xl | Descriptor: | Apoptosis regulator Bcl-X | Authors: | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | Deposit date: | 2003-06-17 | Release date: | 2003-09-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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1PQ1
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![BU of 1pq1 by Molmil](/molmil-images/mine/1pq1) | Crystal structure of Bcl-xl/Bim | Descriptor: | Apoptosis regulator Bcl-X, BCL2-like protein 11 | Authors: | Liu, X, Dai, S, Zhu, Y, Marrack, P, Kappler, J.W. | Deposit date: | 2003-06-17 | Release date: | 2003-09-23 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The structure of a Bcl-xl/Bim fragment complex: Implications for Bim function Immunity, 19, 2003
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7BOR
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![BU of 7bor by Molmil](/molmil-images/mine/7bor) | Structure of Pseudomonas aeruginosa CoA-bound OdaA | Descriptor: | COENZYME A, Probable enoyl-CoA hydratase/isomerase | Authors: | Zhao, N, Zhao, C, Liu, L, Li, T, Li, C, He, L, Zhu, Y, Song, Y, Bao, R. | Deposit date: | 2020-03-19 | Release date: | 2020-05-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Structural and molecular dynamic studies of Pseudomonas aeruginosa OdaA reveal the regulation role of a C-terminal hinge element. Biochim Biophys Acta Gen Subj, 1865, 2020
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4QYY
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![BU of 4qyy by Molmil](/molmil-images/mine/4qyy) | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | Descriptor: | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. | Deposit date: | 2014-07-26 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
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8W6Z
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![BU of 8w6z by Molmil](/molmil-images/mine/8w6z) | Substrate-bound crystal structure of a P450 enzyme DmlH that catalyze intramolecular phenol coupling in the biosynthesis of cihanmycins | Descriptor: | (E)-3-[2-[(2R,3S)-3-[(1R)-1-aminocarbonyloxypropyl]oxiran-2-yl]phenyl]prop-2-enoic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Fang, C, Zhang, L, Zhu, Y, Zhang, C. | Deposit date: | 2023-08-30 | Release date: | 2024-06-12 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Substrate-bound crystal structure of a P450 enzyme DmlH that catalyze intramolecular phenol coupling in the biosynthesis of cihanmycins To Be Published
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8W72
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![BU of 8w72 by Molmil](/molmil-images/mine/8w72) | |
5DNP
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![BU of 5dnp by Molmil](/molmil-images/mine/5dnp) | Crystal structure of Mmi1 YTH domain | Descriptor: | PHOSPHATE ION, YTH domain-containing protein mmi1 | Authors: | Wang, C.Y, Zhu, Y.W, Shi, Y.Y, Wu, J.H. | Deposit date: | 2015-09-10 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1 Nucleic Acids Res., 44, 2016
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4EAY
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![BU of 4eay by Molmil](/molmil-images/mine/4eay) | Crystal structures of mannonate dehydratase from Escherichia coli strain K12 complexed with D-mannonate | Descriptor: | CHLORIDE ION, D-MANNONIC ACID, MANGANESE (II) ION, ... | Authors: | Qiu, X, Zhu, Y, Yuan, Y, Zhang, Y, Liu, H, Gao, Y, Teng, M, Niu, L. | Deposit date: | 2012-03-23 | Release date: | 2013-03-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. J.Struct.Biol., 180, 2012
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4EF4
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![BU of 4ef4 by Molmil](/molmil-images/mine/4ef4) | Crystal structure of STING CTD complex with c-di-GMP | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173 | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | Deposit date: | 2012-03-29 | Release date: | 2012-05-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.147 Å) | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding Immunity, 36, 2012
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4EAC
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![BU of 4eac by Molmil](/molmil-images/mine/4eac) | Crystal structure of mannonate dehydratase from Escherichia coli strain K12 | Descriptor: | CHLORIDE ION, MANGANESE (II) ION, Mannonate dehydratase | Authors: | Qiu, X, Zhu, Y, Yuan, Y, Zhang, Y, Liu, H, Gao, Y, Teng, M, Niu, L. | Deposit date: | 2012-03-22 | Release date: | 2013-03-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. J.Struct.Biol., 180, 2012
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5DNO
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![BU of 5dno by Molmil](/molmil-images/mine/5dno) | Crystal structure of Mmi1 YTH domain complex with RNA | Descriptor: | RNA (5'-R(*CP*UP*UP*AP*AP*AP*C)-3'), YTH domain-containing protein mmi1 | Authors: | Wang, C.Y, Zhu, Y.W, Wu, J.H, Shi, Y.Y. | Deposit date: | 2015-09-10 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1 Nucleic Acids Res., 44, 2016
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4EF5
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![BU of 4ef5 by Molmil](/molmil-images/mine/4ef5) | Crystal structure of STING CTD | Descriptor: | Transmembrane protein 173 | Authors: | Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J. | Deposit date: | 2012-03-29 | Release date: | 2012-05-16 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding Immunity, 36, 2012
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8IQ0
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![BU of 8iq0 by Molmil](/molmil-images/mine/8iq0) | Crystal structure of hydrogen sulfide-bound superoxide dismutase in oxidized state | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ... | Authors: | Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C. | Deposit date: | 2023-03-15 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme. Cell Rep, 42, 2023
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8IQ1
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![BU of 8iq1 by Molmil](/molmil-images/mine/8iq1) | Crystal structure of hydrogen sulfide-bound superoxide dismutase in reduced state | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ... | Authors: | Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C. | Deposit date: | 2023-03-15 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme. Cell Rep, 42, 2023
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3VNI
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![BU of 3vni by Molmil](/molmil-images/mine/3vni) | Crystal structures of D-Psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars | Descriptor: | MANGANESE (II) ION, Xylose isomerase domain protein TIM barrel | Authors: | Chan, H.C, Zhu, Y, Hu, Y, Ko, T.P, Huang, C.H, Ren, F, Chen, C.C, Guo, R.T, Sun, Y. | Deposit date: | 2012-01-16 | Release date: | 2012-08-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars. Protein Cell, 3, 2012
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6UI4
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![BU of 6ui4 by Molmil](/molmil-images/mine/6ui4) | Crystal structure of phenamacril-bound F. graminearum myosin I | Descriptor: | Calmodulin, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Zhou, Y, Zhou, X.E, Gong, Y, Zhu, Y, Xu, H.E, Zhou, M, Melcher, K, Zhang, F. | Deposit date: | 2019-09-30 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis of Fusarium myosin I inhibition by phenamacril. Plos Pathog., 16, 2020
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3VNJ
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![BU of 3vnj by Molmil](/molmil-images/mine/3vnj) | Crystal structures of D-Psicose 3-epimerase with D-psicose from Clostridium cellulolyticum H10 | Descriptor: | D-psicose, MANGANESE (II) ION, Xylose isomerase domain protein TIM barrel | Authors: | Chan, H.C, Zhu, Y, Hu, Y, Ko, T.P, Huang, C.H, Ren, F, Chen, C.C, Guo, R.T, Sun, Y. | Deposit date: | 2012-01-16 | Release date: | 2012-08-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars. Protein Cell, 3, 2012
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