4DEB
 
 | | Aurora A in complex with RK2-17-01 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-2-yl)amino]benzamide, Aurora kinase A | | 著者 | Martin, M.P, Zhu, J.-Y, Schonbrunn, E. | | 登録日 | 2012-01-20 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors.
J.Med.Chem., 55, 2012
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8EQN
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4ZMG
 | | Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 | | 分子名称: | 1-(3,5-difluoro-3'-methoxybiphenyl-4-yl)-3-(1,3-thiazol-5-yl)urea, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Ren, X.L, Zhu, J.S, Zhu, L.L, Li, H.L. | | 登録日 | 2015-05-04 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338
To Be Published
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7BYJ
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3MME
 | | Structure and functional dissection of PG16, an antibody with broad and potent neutralization of HIV-1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PG16 HEAVY CHAIN FAB, ... | | 著者 | Pancera, M, McLellan, J, Zhou, T, Zhu, J, Kwong, P. | | 登録日 | 2010-04-19 | | 公開日 | 2010-06-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.97 Å) | | 主引用文献 | Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84, 2010
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3K72
 | | Structure of integrin alphaX beta2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Xie, C, Zhu, J, Chen, X, Mi, L, Nishida, N, Springer, T.A. | | 登録日 | 2009-10-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
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3K6S
 | | Structure of integrin alphaXbeta2 ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Xie, C, Zhu, J, Chen, X, Mi, L, Nishida, N, Springer, T.A. | | 登録日 | 2009-10-09 | | 公開日 | 2010-01-12 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
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3K1Q
 | | Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics | | 分子名称: | Core protein VP6, Outer capsid VP5, Outer capsid VP7, ... | | 著者 | Cheng, L.P, Zhu, J, Hiu, W.H, Zhang, X.K, Honig, B, Fang, Q, Zhou, Z.H. | | 登録日 | 2009-09-28 | | 公開日 | 2010-03-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Backbone Model of an Aquareovirus Virion by Cryo-Electron Microscopy and Bioinformatics
J.Mol.Biol., 397, 2010
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3K71
 | | Structure of integrin alphaX beta2 ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Xie, C, Zhu, J, Chen, X, Mi, L, Nishida, N, Springer, T.A. | | 登録日 | 2009-10-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.95 Å) | | 主引用文献 | Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
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6IDX
 | | Crystal Structure of BAI1/ELMO2 complex | | 分子名称: | Adhesion G protein-coupled receptor B1, Engulfment and cell motility protein 2 | | 著者 | Weng, Z.F, Lin, L, Zhu, J.W, Zhang, R.G. | | 登録日 | 2018-09-11 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds
Nat Commun, 10, 2019
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4ERW
 | | CDK2 in complex with staurosporine | | 分子名称: | 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, STAUROSPORINE | | 著者 | Alam, R, Martin, M.P, Zhu, J.-Y, Schonbrunn, E. | | 登録日 | 2012-04-20 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.
Chembiochem, 13, 2012
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6IE1
 | | Crystal Structure of ELMO2(Engulfment and cell motility protein 2) | | 分子名称: | Engulfment and cell motility protein 2, GLYCEROL | | 著者 | Weng, Z.F, Lin, L, Zhang, R.G, Zhu, J.W. | | 登録日 | 2018-09-12 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds
Nat Commun, 10, 2019
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3H3B
 | | Crystal structure of the single-chain Fv (scFv) fragment of an anti-ErbB2 antibody chA21 in complex with residues 1-192 of ErbB2 extracellular domain | | 分子名称: | Receptor tyrosine-protein kinase erbB-2, anti-ErbB2 antibody chA21 | | 著者 | Zhou, H, Liu, Y, Niu, L, Zhu, J, Teng, M. | | 登録日 | 2009-04-16 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structural Insights into the Down-regulation of Overexpressed p185her2/neu Protein of Transformed Cells by the Antibody chA21.
J.Biol.Chem., 286, 2011
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4EZ3
 | | CDK2 in complex with NSC 134199 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(E)-(6-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)diazenyl]benzenesulfonamide, Cyclin-dependent kinase 2 | | 著者 | Alam, R, Martin, M, Zhu, J.-Y, Schonbrunn, E. | | 登録日 | 2012-05-02 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.
Chembiochem, 13, 2012
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4EZ7
 | | CDK2 in complex with staurosporine and 2 molecules of 8-anilino-1-naphthalene sulfonic acid | | 分子名称: | 1,2-ETHANEDIOL, 8-ANILINO-1-NAPHTHALENE SULFONATE, Cyclin-dependent kinase 2, ... | | 著者 | Alam, R, Martin, M.P, Zhu, J.-Y, Schonbrunn, E. | | 登録日 | 2012-05-02 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.
Chembiochem, 13, 2012
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5LDX
 | | Structure of mammalian respiratory Complex I, class3. | | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Vinothkumar, K.R, Zhu, J, Hirst, J. | | 登録日 | 2016-06-28 | | 公開日 | 2016-09-14 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | | 主引用文献 | Structure of mammalian respiratory complex I.
Nature, 536, 2016
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5LC5
 | | Structure of mammalian respiratory Complex I, class2 | | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Vinothkumar, K.R, Zhu, J, Hirst, J. | | 登録日 | 2016-06-19 | | 公開日 | 2016-09-07 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | | 主引用文献 | Structure of mammalian respiratory complex I.
Nature, 536, 2016
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5LDW
 | | Structure of mammalian respiratory Complex I, class1 | | 分子名称: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Vinothkumar, K.R, Zhu, J, Hirst, J. | | 登録日 | 2016-06-28 | | 公開日 | 2016-09-07 | | 最終更新日 | 2019-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | | 主引用文献 | Structure of mammalian respiratory complex I.
Nature, 536, 2016
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1T49
 | | Allosteric Inhibition of Protein Tyrosine Phosphatase 1B | | 分子名称: | 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE, MAGNESIUM ION, Protein-tyrosine phosphatase, ... | | 著者 | Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K. | | 登録日 | 2004-04-28 | | 公開日 | 2004-07-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Allosteric inhibition of protein tyrosine phosphatase 1B.
Nat.Struct.Mol.Biol., 11, 2004
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1T4J
 | | Allosteric Inhibition of Protein Tyrosine Phosphatase 1B | | 分子名称: | 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID [4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE, Protein-tyrosine phosphatase, non-receptor type 1 | | 著者 | Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K. | | 登録日 | 2004-04-29 | | 公開日 | 2004-07-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
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1T48
 | | Allosteric Inhibition of Protein Tyrosine Phosphatase 1B | | 分子名称: | 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID DIMETHYLAMIDE, Protein-tyrosine phosphatase, non-receptor type 1 | | 著者 | Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Erlanson, D.A, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K. | | 登録日 | 2004-04-28 | | 公開日 | 2004-07-20 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Allosteric inhibition of protein tyrosine phosphatase 1B
Nat.Struct.Mol.Biol., 11, 2004
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2FQO
 | | Crystal structure of B. subtilis LuxS in complex with (2S)-2-Amino-4-[(2R,3R)-2,3-dihydroxy-3-N- hydroxycarbamoyl-propylmercapto]butyric acid | | 分子名称: | (2S)-2-AMINO-4-[(2R,3R)-2,3-DIHYDROXY-3-N-HYDROXYCARBAMOYL-PROPYLMERCAPTO]BUTYRIC ACID, COBALT (II) ION, S-ribosylhomocysteine lyase, ... | | 著者 | Shen, G, Rajan, R, Zhu, J, Bell, C.E, Pei, D. | | 登録日 | 2006-01-18 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Design and Synthesis of Substrate and Intermediate Analogue Inhibitors of S-Ribosylhomocysteinase
J.Med.Chem., 49, 2006
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2FQT
 | | Crystal structure of B.subtilis LuxS in complex with (2S)-2-Amino-4-[(2R,3S)-2,3-dihydroxy-3-N-hydroxycarbamoyl-propylmercapto]butyric acid | | 分子名称: | (2S)-2-AMINO-4-[(2R,3S)-2,3-DIHYDROXY-3-N-HYDROXYCARBAMOYL-PROPYLMERCAPTO]BUTYRIC ACID, COBALT (II) ION, S-ribosylhomocysteine lyase, ... | | 著者 | Shen, G, Rajan, R, Zhu, J, Bell, C.E, Pei, D. | | 登録日 | 2006-01-18 | | 公開日 | 2006-05-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Design and Synthesis of Substrate Analogue Inhibitors of S-Ribosylhomocysteinase (LuxS)
J.Med.Chem., 49, 2006
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8G57
 | | Structure of nucleosome-bound Sirtuin 6 deacetylase | | 分子名称: | DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ... | | 著者 | Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P. | | 登録日 | 2023-02-11 | | 公開日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Cryo-EM structure of the human Sirtuin 6-nucleosome complex.
Sci Adv, 9, 2023
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3NJP
 | | The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, Epidermal growth factor receptor, ... | | 著者 | Lu, C, Mi, L.-Z, Grey, M.J, Zhu, J, Graef, E, Yokoyama, S, Springer, T.A. | | 登録日 | 2010-06-17 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | | 主引用文献 | Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.
Mol.Cell.Biol., 30, 2010
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