4EZ3

CDK2 in complex with NSC 134199

Summary for 4EZ3

Related4ERW 4EZ7
DescriptorCyclin-dependent kinase 2, 4-[(E)-(6-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)diazenyl]benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsprotein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, centrosome P24941
Total number of polymer chains1
Total molecular weight35117.7
Authors
Alam, R.,Martin, M.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2012-05-02, release date: 2012-08-22, Last modification date: 2012-10-03)
Primary citation
Martin, M.P.,Alam, R.,Betzi, S.,Ingles, D.J.,Zhu, J.Y.,Schonbrunn, E.
A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2.
Chembiochem, 13:2128-2136, 2012
PubMed: 22893598 (PDB entries with the same primary citation)
DOI: 10.1002/cbic.201200316
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244130.3%0.8%11.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution