The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling

Summary for 3NJP

DescriptorEpidermal growth factor receptor, Epidermal growth factor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordsreceptor tyrosine kinase, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total molecular weight151812.47
Lu, C.,Mi, L.-Z.,Grey, M.J.,Zhu, J.,Graef, E.,Yokoyama, S.,Springer, T.A. (deposition date: 2010-06-17, release date: 2010-10-13, Last modification date: 2020-07-29)
Primary citation
Lu, C.,Mi, L.Z.,Grey, M.J.,Zhu, J.,Graef, E.,Yokoyama, S.,Springer, T.A.
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.
Mol.Cell.Biol., 30:5432-5443, 2010
PubMed: 20837704 (PDB entries with the same primary citation)
DOI: 10.1128/MCB.00742-10
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28211 0.8% 0.2% 7.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02