3NJP
The Extracellular and Transmembrane Domain Interfaces in Epidermal Growth Factor Receptor Signaling
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 614 | 67987.4 | 2 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Homo sapiens (human) | Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1 |
| 2 | C, D (C, D) | Epidermal growth factor | polymer | 47 | 5555.3 | 2 | UniProt (Q6QBS2) Pfam (PF00008) UniProt (by SIFTS) (P01133) | Homo sapiens (human) | |
| 3 | E, F, G, H, I... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 4 | Q, R, S, T, U (B, D) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 5 | Chemie (2PE) | |||
| 5 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 614 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Lys 516 | Asn 540 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 147085.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4726.9 | |
| All* | Total formula weight | 151812.5 |
