3X22
| Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W | 分子名称: | FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | 著者 | Bai, J, Yang, J, Zhou, Y, Yang, Q. | 登録日 | 2014-12-06 | 公開日 | 2015-11-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Structural basis of Escherichia coli nitroreductase NfsB triple mutants engineered for improved activity and regioselectivity toward the prodrug CB1954 PROCESS BIOCHEM, 50, 2015
|
|
5AX8
| Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase | 分子名称: | Aspartate aminotransferase, mitochondrial | 著者 | Jiang, X, Wang, J, Chang, H, Zhou, Y. | 登録日 | 2015-07-20 | 公開日 | 2016-03-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.989 Å) | 主引用文献 | Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase Biosci Trends, 10, 2016
|
|
1BK9
| PHOSPHOLIPASE A2 MODIFIED BY PBPB | 分子名称: | 1,4-BUTANEDIOL, CALCIUM ION, PHOSPHOLIPASE A2, ... | 著者 | Zhao, H, Tang, L, Wang, X, Lin, Z, Zhou, Y. | 登録日 | 1998-07-16 | 公開日 | 1999-03-02 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of a snake venom phospholipase A2 modified by p-bromo-phenacyl-bromide. Toxicon, 36, 1998
|
|
7YFN
| Core module of the NuA4 complex in S. cerevisiae | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ARP4 isoform 1, Actin, ... | 著者 | Ji, L.T, Zhao, L.X, Xu, K, Gao, H.H, Zhou, Y, Kornberg, R.D, Zhang, H.Q. | 登録日 | 2022-07-08 | 公開日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of the NuA4 histone acetyltransferase complex. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7YFP
| The NuA4 histone acetyltransferase complex from S. cerevisiae | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ARP4 isoform 1, Actin, ... | 著者 | Ji, L.T, Zhao, L.X, Xu, K, Gao, H.H, Zhou, Y, Kornberg, R.D, Zhang, H.Q. | 登録日 | 2022-07-08 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of the NuA4 histone acetyltransferase complex. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
5WIE
| Crystal structure of a Kv1.2-2.1 chimera K+ channel V406W mutant in an inactivated state | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | 著者 | Pau, V, Zhou, Y, Ramu, Y, Xu, Y, Lu, Z. | 登録日 | 2017-07-19 | 公開日 | 2017-08-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of an inactivated mutant mammalian voltage-gated K(+) channel. Nat. Struct. Mol. Biol., 24, 2017
|
|
3VM7
| Structure of an Alpha-Amylase from Malbranchea cinnamomea | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-amylase, ... | 著者 | Zhou, P, Hu, S.Q, Zhou, Y, Han, P, Yang, S.Q, Jiang, Z.Q. | 登録日 | 2011-12-09 | 公開日 | 2013-05-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | A Novel Multifunctional alpha-Amylase from the Thermophilic Fungus Malbranchea cinnamomea: Biochemical Characterization and Three-Dimensional Structure. Appl Biochem Biotechnol., 170, 2013
|
|
4M3Q
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | 著者 | Zhang, W, Zhang, D, Stashko, M.A, DeRyckere, D, Hunter, D, Kireev, D.B, Miley, M, Cummings, C, Lee, M, Norris-Drouin, J, Stewart, W.M, Sather, S, Zhou, Y, Kirkpatrick, G, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-06 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.718 Å) | 主引用文献 | Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors. J.Med.Chem., 56, 2013
|
|
4MH7
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-methylpyrimidine-5-carboxamide, ... | 著者 | Zhang, W, McIver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, M.J, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, DiPaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
|
|
4MHA
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817 | 分子名称: | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Zhang, W, Mciver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, D.B.M, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, Dipaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
|
|
5ZNT
| Insect chitin deacetylase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... | 著者 | Liu, L, Zhou, Y, Yang, Q. | 登録日 | 2018-04-10 | 公開日 | 2019-02-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | 主引用文献 | Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetylases of the carbohydrate esterase 4 family. J. Biol. Chem., 294, 2019
|
|
5ZNS
| Insect chitin deacetylase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... | 著者 | Liu, L, Zhou, Y, Yang, Q. | 登録日 | 2018-04-10 | 公開日 | 2019-02-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | 主引用文献 | Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetylases of the carbohydrate esterase 4 family. J. Biol. Chem., 294, 2019
|
|
7W0V
| C4'-SCF3-DT modifeid DNA-DNA duplex | 分子名称: | DNA (5'-D(*CP*CP*AP*TP*(DSW)P*AP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*TP*GP*G)-3') | 著者 | Li, Q, Trajkovski, M, Fan, C, Chen, J, Zhou, Y, Lu, K, Li, H, Su, X, Xi, Z, Plavec, J, Zhou, C. | 登録日 | 2021-11-18 | 公開日 | 2022-11-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | 4'-SCF 3 -Labeling Constitutes a Sensitive 19 F NMR Probe for Characterization of Interactions in the Minor Groove of DNA. Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7TAD
| CryoEM structure of the (NPR1)2-(TGA3)2 complex | 分子名称: | PALMITIC ACID, Regulatory protein NPR1, Transcription factor TGA3, ... | 著者 | Wu, Q, Zhou, Y, Bartesaghi, A, Dong, X, Zhou, P. | 登録日 | 2021-12-20 | 公開日 | 2022-03-16 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of NPR1 in activating plant immunity. Nature, 605, 2022
|
|
7TAC
| Cryo-EM structure of the (TGA3)2-(NPR1)2-(TGA3)2 complex | 分子名称: | PALMITIC ACID, Regulatory protein NPR1, Transcription factor TGA3, ... | 著者 | Wu, Q, Zhou, Y, Bartesaghi, A, Dong, X, Zhou, P. | 登録日 | 2021-12-20 | 公開日 | 2022-03-16 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of NPR1 in activating plant immunity. Nature, 605, 2022
|
|
5WUP
| |
5WVG
| |
5WUS
| |
5WVB
| |
5WVH
| |
5WVF
| |
5WV8
| |
5WV9
| |
8JBP
| Crystal structure of triosephosphate isomerase from Leishmania orientalis at 1.45 angstroms resolution with an arsenic atom bound at Cys57 | 分子名称: | ARSENIC, Triosephosphate isomerase | 著者 | Kuaprasert, B, Leartsakulpanich, U, Riangrungroj, P, Pornthanakasem, W, Suginta, W, Robinson, R.C, Zhou, Y, Mungthin, M, Leelayoova, S, Saehlee, S, Choowongkomon, K. | 登録日 | 2023-05-09 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Leishmania orientalis triosephosphate isomerase crystal structure at 1.45 angstroms resolution and its potential specific inhibitors To be published
|
|
5Y1B
| Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with a berberine derivative (SYSU-00679) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 9-O-3'-quinolinium propylberberine, Beta-hexosaminidase | 著者 | Duan, Y.W, Liu, T, Zhou, Y, Tang, J.Y, Li, M, Yang, Q. | 登録日 | 2017-07-20 | 公開日 | 2018-01-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.207 Å) | 主引用文献 | Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine. J. Biol. Chem., 293, 2018
|
|