8JED
| Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors | Descriptor: | mRNA-capping enzyme regulatory subunit OPG124 | Authors: | Wang, D, Zhao, R, Shu, W, Hu, W, Wang, M, Cao, J, Zhou, X. | Deposit date: | 2023-05-15 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors. Int.J.Biol.Macromol., 253, 2023
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7D5I
| Structure of Mycobacterium smegmatis bd complex in the apo-form. | Descriptor: | CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, Cytochrome D ubiquinol oxidase subunit 1, HEME B/C, ... | Authors: | Wang, W, Gong, H, Gao, Y, Zhou, X, Rao, Z. | Deposit date: | 2020-09-26 | Release date: | 2021-06-23 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.79 Å) | Cite: | Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels. Nat Commun, 12, 2021
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7CMU
| Dopamine Receptor D3R-Gi-Pramipexole complex | Descriptor: | (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | Deposit date: | 2020-07-29 | Release date: | 2021-03-10 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
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7CMV
| Dopamine Receptor D3R-Gi-PD128907 complex | Descriptor: | (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Mao, C, Krumm, B, Zhou, X, Tan, Y, Huang, X.-P, Liu, Y, Shen, D.-D, Jiang, Y, Yu, X, Jiang, H, Melcher, K, Roth, B, Cheng, X, Zhang, Y, Xu, H. | Deposit date: | 2020-07-29 | Release date: | 2021-03-10 | Last modified: | 2021-04-07 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structures of the human dopamine D3 receptor-G i complexes. Mol.Cell, 81, 2021
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7Y9B
| Crystal structure of the membrane (M) protein of a SARS-COV-2-related coronavirus | Descriptor: | 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Membrane protein | Authors: | Wang, X, Sun, Z, Zhou, X. | Deposit date: | 2022-06-24 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.214 Å) | Cite: | Crystal structure of the membrane (M) protein from a bat betacoronavirus. Pnas Nexus, 2, 2023
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7Y96
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7CYG
| Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter before disulfide bond formation | Descriptor: | Transporter, sodium/bile acid symporter family | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-09-03 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.198 Å) | Cite: | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter. Acta Crystallogr D Struct Biol, 77, 2021
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7CYK
| Crystal structure of a second cysteine-pair mutant (V110C-I197C) of a bacterial bile acid transporter before disulfide bond formation | Descriptor: | MERCURY (II) ION, Transporter, sodium/bile acid symporter family | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | Deposit date: | 2020-09-03 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.785 Å) | Cite: | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter. Acta Crystallogr D Struct Biol, 77, 2021
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7Y5H
| Cryo-EM structure of a eukaryotic ZnT8 at a low pH | Descriptor: | ZINC ION, Zinc transporter 8 | Authors: | Zhang, S, Fu, C, Luo, Y, Sun, Z, Su, Z, Zhou, X. | Deposit date: | 2022-06-17 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn 2+ -releasing mechanism. J.Struct.Biol., 215, 2022
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7Y5G
| Cryo-EM structure of a eukaryotic ZnT8 in the presence of zinc | Descriptor: | ZINC ION, Zinc transporter 8 | Authors: | Zhang, S, Fu, C, Luo, Y, Sun, Z, Su, Z, Zhou, X. | Deposit date: | 2022-06-17 | Release date: | 2022-12-14 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn 2+ -releasing mechanism. J.Struct.Biol., 215, 2022
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7W2B
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7W2H
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7W2C
| The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 | Descriptor: | 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, GOLD ION, Sigma non-opioid intracellular receptor 1, ... | Authors: | Meng, F, Sun, Z, Zhou, X. | Deposit date: | 2021-11-23 | Release date: | 2022-03-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.335 Å) | Cite: | An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway. Nat Commun, 13, 2022
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7W2E
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7W2G
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7W2F
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7W2D
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7C72
| Structure of a mycobacterium tuberculosis puromycin-hydrolyzing peptidase | Descriptor: | D-MALATE, GLYCEROL, Prolyl oligopeptidase | Authors: | Ruiz-Carrillo, D, Zhao, Y.H, Feng, Q, Zhou, X, Zhang, Y, Jiang, J, Lukman, M. | Deposit date: | 2020-05-22 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.00004458 Å) | Cite: | Mycobacterium tuberculosis puromycin hydrolase displays a prolyl oligopeptidase fold and an acyl aminopeptidase activity. Proteins, 89, 2021
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7WXG
| GPR domain closed form of Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WXF
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7WXI
| GPR domain of Drosophila P5CS filament with glutamate and ATPgammaS | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WXH
| GPR domain open form of Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-03-30 | Last modified: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WX4
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7WX3
| GK domain of Drosophila P5CS filament with glutamate, ATP, and NADPH | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Delta-1-pyrroline-5-carboxylate synthase, GAMMA-GLUTAMYL PHOSPHATE, ... | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | Deposit date: | 2022-02-14 | Release date: | 2022-04-06 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of dynamic P5CS filaments. Elife, 11, 2022
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7WD4
| Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, NS3 helicase | Authors: | Wang, D.P, Wang, M.Y, Zhou, X, Wang, W.M, Cao, J.M. | Deposit date: | 2021-12-21 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design To Be Published
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