6D1W
| human PKD2 F604P mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E. | Deposit date: | 2018-04-12 | Release date: | 2018-06-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun, 9, 2018
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8EHX
| cryo-EM structure of TMEM63B in LMNG | Descriptor: | CSC1-like protein 2 | Authors: | Zheng, W, Fu, T.M, Holt, J.R. | Deposit date: | 2022-09-14 | Release date: | 2023-08-23 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron, 111, 2023
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8EHW
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7EHW
| BRD4-BD1 in complex with LT-642-602 | Descriptor: | 1-[4-ethyl-2-methyl-5-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | Deposit date: | 2021-03-30 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | BRD4-BD1 in complex with LT-642-602 To Be Published
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7EHY
| BRD4-BD1 in complex with LT-448-138 | Descriptor: | 1-[2,4-dimethyl-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | Deposit date: | 2021-03-30 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | BRD4-BD1 in complex with LT-642-602 To Be Published
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7EIG
| BRD4-BD1 in complex with LT-730-903 | Descriptor: | 1-[5-(5-azanyl-1H-benzimidazol-2-yl)-2-methyl-4-phenyl-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | Deposit date: | 2021-03-31 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | BRD4-BD1 in complex with LT-730-903 To Be Published
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7EIK
| RD4-BD1 in complex with LT-872-297 | Descriptor: | 1-[2-methyl-5-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-4-(1-methylpyrazol-4-yl)-1H-pyrrol-3-yl]ethanone, Bromodomain-containing protein 4 | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | Deposit date: | 2021-03-31 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | RD4-BD1 in complex with LT-872-297 To Be Published
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7EIL
| BRD4-BD1 in complex with LT-909-110 | Descriptor: | Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide | Authors: | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | Deposit date: | 2021-03-31 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy Eur.J.Med.Chem., 227, 2022
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8UEQ
| In-situ complex I with Q10 (State-beta) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UEY
| In-situ complex I, Deactive class07 | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGG
| In-situ complex III, state IV | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UD1
| High resolution in-situ structure of complex I in respiratory supercomplex (composite) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-09-27 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UEP
| In-situ complex I, Active-Q10 (State-alpha) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UEU
| In-situ complex I, Deactive class03 | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGD
| In-situ complex III, state I | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGK
| High resolution in-situ structure of complex III in respiratory supercomplex (composite) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGE
| In-situ complex III, state II | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGF
| In-situ complex III, state III | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UEW
| In-situ complex I, Deactive class05 | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGH
| In-situ structure of typeA supercomplex with lipids in respiratory chain (composite) | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGI
| High resolution in-situ structure of typeA supercomplex in respiratory chain (I1III2IV1,composite) | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGJ
| In-situ structure of typeB supercomplex in respiratory chain (composite) | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGN
| In-situ structure of typeO supercomplex in respiratory chain (composite) | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-05 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UGR
| In-situ structure of typeX supercomplex in respiratory chain (composite) | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Zheng, W, Zhang, K, Zhu, J. | Deposit date: | 2023-10-06 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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8UET
| In-situ complex I, Deactive class02 | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | Authors: | Zheng, W, Zhu, J, Zhang, K. | Deposit date: | 2023-10-02 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 2024
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