7Y57
 
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5Z1V
 | | Crystal structure of AvrPib | | Descriptor: | AvrPib protein | | Authors: | Zhang, X, He, D, Zhao, Y.X, Taylor, I.A, Peng, Y.L, Yang, J, Liu, J.F. | | Deposit date: | 2017-12-28 | | Release date: | 2018-09-05 | | Last modified: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (1.661 Å) | | Cite: | A positive-charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus.
Plant J., 96, 2018
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6IMI
 | | Crystal structure of PDE4D complexed with a novel inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 6-ethoxy-7-methoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde, MAGNESIUM ION, ... | | Authors: | Zhang, X, Su, H, Xu, Y. | | Deposit date: | 2018-10-23 | | Release date: | 2019-10-23 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.
J.Med.Chem., 62, 2019
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5ZIW
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5ZKZ
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8IEW
 | | Cas005-crRNA-DNA complex | | Descriptor: | Cas005, DNA (55-MER), RNA (38-MER) | | Authors: | Zhang, X, Duan, Z.Q, Zhu, J.K. | | Deposit date: | 2023-02-16 | | Release date: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of Cas005-crRNA-DNA complex at 3.1 Angstroms resolution
To Be Published
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4OA7
 | | Crystal structure of Tankyrase1 in complex with IWR1 | | Descriptor: | 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide, Tankyrase-1, ZINC ION | | Authors: | Zhang, X, He, H. | | Deposit date: | 2014-01-03 | | Release date: | 2015-01-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Mol.Cell.Biol., 35, 2015
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5ZII
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1CFA
 | | SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES | | Descriptor: | COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST, SYNTHETIC N-TERMINAL TAIL | | Authors: | Zhang, X, Boyar, W, Galakatos, N, Gonnella, N.C. | | Deposit date: | 1996-09-21 | | Release date: | 1997-09-17 | | Last modified: | 2024-06-05 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
Protein Sci., 6, 1997
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6K5L
 | | The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli | | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Isocitrate dehydrogenase kinase/phosphatase, ... | | Authors: | Zhang, X, Lei, Z, Zheng, J, Jia, Z. | | Deposit date: | 2019-05-29 | | Release date: | 2019-07-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.
Sci Rep, 9, 2019
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7DV8
 | | The crystal structure of rice immune receptor RGA5-HMA2. | | Descriptor: | Disease resistance protein RGA5 | | Authors: | Zhang, X, Liu, J.F. | | Deposit date: | 2021-01-12 | | Release date: | 2021-10-20 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.447 Å) | | Cite: | A designer rice NLR immune receptor confers resistance to the rice blast fungus carrying noncorresponding avirulence effectors.
Proc.Natl.Acad.Sci.USA, 118, 2021
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5XUR
 | | Crystal Structure of Rv2466c C22S Mutant | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Thioredoxin-like reductase Rv2466c | | Authors: | Zhang, X, Li, H. | | Deposit date: | 2017-06-25 | | Release date: | 2018-03-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.996 Å) | | Cite: | Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
ACS Infect Dis, 4, 2018
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6JK8
 | | Cryo-EM structure of the full-length human IGF-1R in complex with insulin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | | Authors: | Zhang, X, Yu, D, Wang, T. | | Deposit date: | 2019-02-27 | | Release date: | 2020-03-04 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis.
Structure, 28, 2020
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7KI0
 | | Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein | | Descriptor: | 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | | Deposit date: | 2020-10-22 | | Release date: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes.
Cell Rep, 36, 2021
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7KI1
 | | Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein | | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | | Deposit date: | 2020-10-22 | | Release date: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes.
Cell Rep, 36, 2021
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2MQ0
 | | NMR structure of the c3 domain of human cardiac myosin binding protein-c | | Descriptor: | Myosin-binding protein C, cardiac-type | | Authors: | Zhang, X, De, S, Mcintosh, L.P, Paetzel, M. | | Deposit date: | 2014-06-10 | | Release date: | 2014-07-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant.
Biochemistry, 53, 2014
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2MQ3
 | | NMR structure of the c3 domain of human cardiac myosin binding protein-c with a hypertrophic cardiomyopathy-related mutation R502W. | | Descriptor: | Myosin-binding protein C, cardiac-type | | Authors: | Zhang, X, De, S, Mcintosh, L.P, Paetzel, M. | | Deposit date: | 2014-06-12 | | Release date: | 2014-07-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant.
Biochemistry, 53, 2014
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3J4U
 | | A new topology of the HK97-like fold revealed in Bordetella bacteriophage: non-covalent chainmail secured by jellyrolls | | Descriptor: | cementing protein, major capsid protein | | Authors: | Zhang, X, Guo, H, Jin, L, Czornyj, E, Hodes, A, Hui, W.H, Nieh, A.W, Miller, J.F, Zhou, Z.H. | | Deposit date: | 2013-10-09 | | Release date: | 2013-12-25 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 A resolution.
Elife, 2, 2013
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5XWY
 | | Electron cryo-microscopy structure of LbuCas13a-crRNA binary complex | | Descriptor: | A type VI-A CRISPR-Cas RNA-guided RNA ribonuclease, Cas13a, RNA (59-MER) | | Authors: | Zhang, X, Wang, Y, Ma, J, Liu, L, Li, X, Li, Z, You, L, Wang, J, Wang, M. | | Deposit date: | 2017-06-30 | | Release date: | 2017-09-13 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017
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2GS7
 | | Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP | | Descriptor: | Epidermal growth factor receptor, IODIDE ION, MAGNESIUM ION, ... | | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | | Deposit date: | 2006-04-25 | | Release date: | 2006-06-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Cell(Cambridge,Mass.), 125, 2006
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7MDO
 | | Structure of human p97 ATPase L464P mutant | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F. | | Deposit date: | 2021-04-05 | | Release date: | 2021-08-25 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.12 Å) | | Cite: | Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity.
Biochem.J., 478, 2021
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7MDM
 | | Structure of human p97 ATPase L464P mutant | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Zhang, X, Gui, L, Li, S, Nandi, P, Columbres, R.C, Wong, D.E, Moen, D.R, Lin, H.J, Chiu, P.-L, Chou, T.-F. | | Deposit date: | 2021-04-05 | | Release date: | 2021-08-25 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.86 Å) | | Cite: | Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity.
Biochem.J., 478, 2021
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2RFD
 | | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION | | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | | Deposit date: | 2007-09-28 | | Release date: | 2007-12-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
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5XJC
 | | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | | Deposit date: | 2017-04-30 | | Release date: | 2017-07-05 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | An Atomic Structure of the Human Spliceosome
Cell, 169, 2017
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6IMM
 | | Cryo-EM structure of an alphavirus, Sindbis virus | | Descriptor: | Assembly protein E3, Octadecane, Spike glycoprotein E1, ... | | Authors: | Zhang, X, Ma, J, Chen, L. | | Deposit date: | 2018-10-23 | | Release date: | 2019-03-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Implication for alphavirus host-cell entry and assembly indicated by a 3.5 angstrom resolution cryo-EM structure.
Nat Commun, 9, 2018
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