2L7E
 
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4DDL
 | | PDE10a Crystal Structure Complexed with Novel Inhibitor | | 分子名称: | 2-{1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]piperidin-4-yl}propan-2-ol, SULFATE ION, ZINC ION, ... | | 著者 | Chmait, S, Jordan, S, Zhang, J. | | 登録日 | 2012-01-18 | | 公開日 | 2012-03-21 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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1A7M
 | | LEUKAEMIA INHIBITORY FACTOR CHIMERA (MH35-LIF), NMR, 20 STRUCTURES | | 分子名称: | LEUKEMIA INHIBITORY FACTOR | | 著者 | Hinds, M.G, Maurer, T, Zhang, J.-G, Nicola, N.A, Norton, R.S. | | 登録日 | 1998-03-16 | | 公開日 | 1999-04-20 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of leukemia inhibitory factor.
J.Biol.Chem., 273, 1998
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5CUQ
 | | Identification and characterization of novel broad spectrum inhibitors of the flavivirus methyltransferase | | 分子名称: | N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, Nonstructural protein NS5 | | 著者 | Brecher, B, Chen, H, Li, Z, Banavali, N.K, Jones, S.A, Zhang, J, Kramer, L.D, Li, H.M. | | 登録日 | 2015-07-24 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase.
Acs Infect Dis., 1, 2015
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2LKZ
 | | Solution structure of the second RRM domain of RBM5 | | 分子名称: | RNA-binding protein 5 | | 著者 | Song, Z, Wu, P, Zhang, J, Wu, J, Shi, Y. | | 登録日 | 2011-10-23 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets
Biochemistry, 2012
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7DK2
 | | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MW07 heavy chain, MW07 light chain, ... | | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M, Chen, S. | | 登録日 | 2020-11-22 | | 公開日 | 2021-12-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Architectural versatility of spike neutralization by a SARS-CoV-2 antibody
To Be Published
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7XMG
 | | Cryo-EM structure of human NaV1.7/beta1/beta2-TCN-1752 | | 分子名称: | (1~{Z})-~{N}-[2-methyl-3-[(~{E})-[6-[4-[[4-(trifluoromethyloxy)phenyl]methoxy]piperidin-1-yl]-1~{H}-1,3,5-triazin-2-ylidene]amino]phenyl]ethanimidic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jiang, D.H, Zhang, J.T. | | 登録日 | 2022-04-25 | | 公開日 | 2022-11-30 | | 最終更新日 | 2022-12-28 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural basis for Na V 1.7 inhibition by pore blockers.
Nat.Struct.Mol.Biol., 29, 2022
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7YHN
 | | ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | | 登録日 | 2022-07-14 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.
J.Med.Chem., 65, 2022
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7Y71
 | | SARS-CoV-2 spike glycoprotein trimer complexed with Fab fragment of anti-RBD antibody E7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab E7 heavy chain, ... | | 著者 | Chia, W.N, Tan, C.W, Tan, A.W.K, Young, B, Starr, T.N, Lopez, E, Fibriansah, G, Barr, J, Cheng, S, Yeoh, A.Y.Y, Yap, W.C, Lim, B.L, Ng, T.S, Sia, W.R, Zhu, F, Chen, S, Zhang, J, Greaney, A.J, Chen, M, Au, G.G, Paradkar, P, Peiris, M, Chung, A.W, Bloom, J.D, Lye, D, Lok, S.M, Wang, L.F. | | 登録日 | 2022-06-21 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor.
Sci Adv, 9, 2023
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3MEX
 | | Crystal structure of MexR in oxidized state | | 分子名称: | Multidrug resistance operon repressor | | 著者 | Chen, H, Yi, C, Zhang, J, Zhang, W, Yang, C.-G, He, C. | | 登録日 | 2010-04-01 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR
Embo Rep., 11, 2010
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7YRZ
 | | Crystal structure of HCoV 229E main protease in complex with PF07321332 | | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase | | 著者 | Zhou, Y.R, Zeng, P, Zhou, X.L, Lin, C, Zhang, J, Yin, X.S, Li, J. | | 登録日 | 2022-08-11 | | 公開日 | 2023-08-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332.
Biochem.Biophys.Res.Commun., 657, 2023
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3VPP
 | | Crystal Structure of the Human CLEC9A C-type Lectin-Like Domain | | 分子名称: | C-type lectin domain family 9 member A, CALCIUM ION | | 著者 | Czabotar, P.E, Zhang, J.G, Policheni, A.N, Shortman, K, Lahoud, M.H, Colman, P.M. | | 登録日 | 2012-03-07 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.642 Å) | | 主引用文献 | The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
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3QYC
 | | Structure of a dimeric anti-HER2 single domain antibody | | 分子名称: | VH domain of IgG molecule | | 著者 | Baral, T.N, Chao, S, Li, S, Tanha, J, Arbabai, M, Wang, S, Zhang, J. | | 登録日 | 2011-03-03 | | 公開日 | 2012-02-08 | | 最終更新日 | 2014-02-05 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of a Human Single Domain Antibody Dimer Formed through V(H)-V(H) Non-Covalent Interactions.
Plos One, 7, 2012
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3HAG
 | | Crystal structure of the Hepatitis E Virus-like Particle | | 分子名称: | Capsid protein | | 著者 | Guu, T.S.Y, Liu, Z, Ye, Q, Mata, D.A, Li, K, Yin, C, Zhang, J, Tao, Y.J. | | 登録日 | 2009-05-01 | | 公開日 | 2009-09-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2OQF
 | | Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A | | 分子名称: | Ribonuclease pancreatic | | 著者 | Boerema, D.J, Tereshko, V.A, Zhang, J.L, He, C, Kent, S.B.H. | | 登録日 | 2007-01-31 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Design, Synthesis, and Characterization of Non-natural RNase A Analogues with Enhanced Second-step Catalytic Activity
To be Published
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2KLI
 | | Structural Basis for the Photoconversion of A Phytochrome to the Activated FAR-RED LIGHT-ABSORBING Form | | 分子名称: | PHYCOCYANOBILIN, Sensor protein | | 著者 | Cornilescu, C.C, Cornilescu, G, Ulijasz, A.T, Zhang, J, Rivera, M, Vierstra, R.D, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2009-07-03 | | 公開日 | 2009-11-03 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the photoconversion of a phytochrome to the activated Pfr form
Nature, 463, 2010
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2KXJ
 | | Solution structure of UBX domain of human UBXD2 protein | | 分子名称: | UBX domain-containing protein 4 | | 著者 | Wu, Q, Huang, H, Zhang, J, Hu, Q, Wu, J, Shi, Y. | | 登録日 | 2010-05-06 | | 公開日 | 2011-05-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution strcture of UBX domain of human UBXD2 protein
To be Published
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7X5V
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7TQB
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6JYX
 | | Structure of CbpJ from Streptococcus Pneumoniae TIGR4 | | 分子名称: | CHOLINE ION, Choline binding protein J, DI(HYDROXYETHYL)ETHER | | 著者 | Xu, Q, Zhang, J.W, Li, Q, Jiang, Y.L. | | 登録日 | 2019-04-29 | | 公開日 | 2019-06-05 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the choline-binding protein CbpJ from Streptococcus pneumoniae.
Biochem.Biophys.Res.Commun., 514, 2019
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4LYC
 | | Cd ions within a lysoyzme single crystal | | 分子名称: | CADMIUM ION, Lysozyme C | | 著者 | Wei, H, House, S, Wu, J, Zhang, J, Wang, Z, He, Y, Gao, Y.-G, Robinson, H, Li, W, Zuo, J.-M, Robertson, I.M, Lu, Y. | | 登録日 | 2013-07-30 | | 公開日 | 2015-02-25 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Enhanced and tunable fluorescent quantum dots within a single crystal of protein
TO BE PUBLISHED
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6UFM
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4NN2
 | | Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein PHF6 | | 分子名称: | GLYCEROL, PHD finger protein 6, ZINC ION | | 著者 | Liu, Z, Li, F, Zhang, J, Mei, Y, Wu, J, Shi, Y. | | 登録日 | 2013-11-16 | | 公開日 | 2014-02-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.472 Å) | | 主引用文献 | Crystal Structure of the second extended PHD domain of human PHF6 protein
J.Biol.Chem., 2014
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7Y3G
 | | Cryo-EM structure of a class A orphan GPCR | | 分子名称: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | | 登録日 | 2022-06-10 | | 公開日 | 2023-06-07 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structural insight into the constitutive activity of human orphan receptor GPR12.
Sci Bull (Beijing), 68, 2023
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7DJZ
 | | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW01 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, MW01 heavy chain, ... | | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | | 登録日 | 2020-11-22 | | 公開日 | 2021-06-09 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | | 主引用文献 | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction.
Commun Biol, 5, 2022
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