4DDL

PDE10a Crystal Structure Complexed with Novel Inhibitor

Summary for 4DDL

• Entry DOI: 10.2210/pdb4ddl/pdb
• Related: 2OUP
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase 10a, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 80326.79

Authors

Chmait, S.,Jordan, S.,Zhang, J. (deposition date: 2012-01-18, release date: 2012-03-21)

• Primary citation: Hu, E.,Kunz, R.K.,Rumfelt, S.,Chen, N.,Burli, R.,Li, C.,Andrews, K.L.,Zhang, J.,Chmait, S.,Kogan, J.,Lindstrom, M.,Hitchcock, S.A.,Treanor, J.; Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.; Bioorg.Med.Chem.Lett., 22:2262-2265, 2012; PubMed: 22365755; DOI: 10.1016/j.bmcl.2012.01.086

Experimental method

X-RAY DIFFRACTION (2.07 Å)