8D67
 
 | | ELIC3 with cysteamine in 2:1:1 POPC:POPE:POPG nanodisc | | Descriptor: | 2-AMINO-ETHANETHIOL, Erwinia ligand-gated ion channel | | Authors: | Petroff II, J.T, Deng, Z, Rau, M.J, Fitzpatrick, J.A.J, Yuan, P, Cheng, W.W.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Nat Commun, 13, 2022
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8D65
 | | ELIC apo in 2:1:1 POPC:POPE:POPG nanodisc | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Erwinia ligand-gated ion channel | | Authors: | Petroff II, J.T, Deng, Z, Rau, M.J, Fitzpatrick, J.A.J, Yuan, P, Cheng, W.W.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Nat Commun, 13, 2022
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8D66
 | | ELIC with cysteamine in 2:1:1 POPC:POPE:POPG nanodisc | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-AMINO-ETHANETHIOL, Erwinia ligand-gated ion channel | | Authors: | Petroff II, J.T, Deng, Z, Rau, M.J, Fitzpatrick, J.A.J, Yuan, P, Cheng, W.W.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Nat Commun, 13, 2022
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8D63
 | | ELIC apo in POPC nanodisc | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Erwinia ligand-gated ion channel | | Authors: | Petroff II, J.T, Deng, Z, Rau, M.J, Fitzpatrick, J.A.J, Yuan, P, Cheng, W.W.L. | | Deposit date: | 2022-06-06 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Nat Commun, 13, 2022
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7JI3
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5IT3
 | | Swirm domain of human Lsd1 | | Descriptor: | Lysine-specific histone demethylase 1A, MAGNESIUM ION | | Authors: | Jeffrey, P.D, Yuan, P. | | Deposit date: | 2016-03-16 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | A Tlx-interacting peptide of Lsd1 inhibits the proliferation of brain tumor stem cells
To Be Published
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4HPF
 | | Structure of the human SLO3 gating ring | | Descriptor: | Potassium channel subfamily U member 1 | | Authors: | Leonetti, M.D, Yuan, P, MacKinnon, R. | | Deposit date: | 2012-10-23 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4KIS
 | | Crystal Structure of a LSR-DNA Complex | | Descriptor: | CALCIUM ION, DNA (26-MER), Putative integrase [Bacteriophage A118], ... | | Authors: | Rutherford, K, Yuan, P, Perry, K, Van Duyne, G.D. | | Deposit date: | 2013-05-02 | | Release date: | 2013-07-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Attachment site recognition and regulation of directionality by the serine integrases.
Nucleic Acids Res., 41, 2013
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4JF7
 | | Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Welch, B.D, Yuan, P, Bose, S, Kors, C.A, Lamb, R.A, Jardetzky, T.S. | | Deposit date: | 2013-02-27 | | Release date: | 2013-09-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.5018 Å) | | Cite: | Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain.
Plos Pathog., 9, 2013
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8TS2
 | | Cryo-EM structure of human MRS2 with EDTA | | Descriptor: | Magnesium transporter MRS2 homolog, mitochondrial, Soluble cytochrome b562 fusion protein | | Authors: | He, Z, Mount, J.W, Zhang, J, Yuan, P. | | Deposit date: | 2023-08-10 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structure and function of the human mitochondrial MRS2 channel.
Nat.Struct.Mol.Biol., 2024
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8TS3
 | | Cryo-EM structure of human MRS2 with Ca2+ | | Descriptor: | CALCIUM ION, Magnesium transporter MRS2 homolog, mitochondrial, ... | | Authors: | He, Z, Mount, J.W, Zhang, J, Yuan, P. | | Deposit date: | 2023-08-10 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structure and function of the human mitochondrial MRS2 channel.
Nat.Struct.Mol.Biol., 2024
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8TS1
 | | Cryo-EM structure of human MRS2 with Mg2+ | | Descriptor: | MAGNESIUM ION, Magnesium transporter MRS2 homolog, mitochondrial, ... | | Authors: | He, Z, Mount, J.W, Zhang, J, Yuan, P. | | Deposit date: | 2023-08-10 | | Release date: | 2024-08-14 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Structure and function of the human mitochondrial MRS2 channel.
Nat.Struct.Mol.Biol., 2024
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7UX1
 | | EcMscK in an Open Conformation | | Descriptor: | Mechanosensitive channel MscK | | Authors: | Mount, J.W, Yuan, P. | | Deposit date: | 2022-05-04 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel.
Nat Commun, 13, 2022
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7UW5
 | | EcMscK G924S mutant in a closed conformation | | Descriptor: | Mechanosensitive channel MscK | | Authors: | Mount, J.W, Yuan, P. | | Deposit date: | 2022-05-02 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel.
Nat Commun, 13, 2022
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3TSI
 | | Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) stalk domain | | Descriptor: | Hemagglutinin-neuraminidase | | Authors: | Bose, S, Welch, B.D, Kors, C.A, Yuan, P, Jardetzky, T.S, Lamb, R.A. | | Deposit date: | 2011-09-13 | | Release date: | 2011-10-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.651 Å) | | Cite: | Structure and mutagenesis of the parainfluenza virus 5 hemagglutinin-neuraminidase stalk domain reveals a four-helix bundle and the role of the stalk in fusion promotion.
J.Virol., 85, 2011
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6M86
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7C92
 | | Structure of Serratia marcescens chitinase B complexed with compound 6k | | Descriptor: | 6-azanyl-11-methyl-2-oxidanylidene-N-(pyridin-3-ylmethyl)-1,7,9-triazatricyclo[8.4.0.0^3,8]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitinase | | Authors: | Jiang, X, Yuan, P.T. | | Deposit date: | 2020-06-04 | | Release date: | 2021-06-09 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | Discovery of novel Chitinase Inhibitors with a scaffold of dipyridopyrimidine-3-carboxamide via Structure-based Rational Design
To Be Published
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7CB1
 | | Structure of Serratia marcescens chitinase B complexed with compound 6q | | Descriptor: | 6-azanyl-11-methyl-2-oxidanylidene-N-[(1S)-1-pyridin-3-ylethyl]-1,7,9-triazatricyclo[8.4.0.0^{3,8}]tetradeca-3,5,7,9,11,13-hexaene-5-carboxamide, Chitinase B | | Authors: | Jiang, X, Yuan, P.T. | | Deposit date: | 2020-06-10 | | Release date: | 2021-06-16 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Discovery of novel Chitinase Inhibitors with a scaffold of dipyridopyrimidine-3-carboxamide via Structure-based Rational Design
To Be Published
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8VUW
 | | ELIC5 with cysteamine in 2:1:1 POPC:POPE:POPG nanodisc in open conformation | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-AMINO-ETHANETHIOL, Erwinia chrysanthemi ligand-gated ion channel | | Authors: | Petroff II, J.T, Deng, Z, Rau, M.J, Fitzpatrick, J.A.J, Yuan, P, Cheng, W.W.L. | | Deposit date: | 2024-01-29 | | Release date: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.
Nat Commun, 13, 2022
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