1NTM
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![BU of 1ntm by Molmil](/molmil-images/mine/1ntm) | Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom | 分子名称: | Cytochrome b, FE2/S2 (INORGANIC) CLUSTER, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Gao, X, Wen, X, Esser, L, Quinn, B, Yu, L, Yu, C, Xia, D. | 登録日 | 2003-01-30 | 公開日 | 2003-10-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for the quinone reduction in the bc(1) complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc(1) with bound substrate and inhibitors at the Q(i) site Biochemistry, 42, 2003
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2X44
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![BU of 2x44 by Molmil](/molmil-images/mine/2x44) | Structure of a strand-swapped dimeric form of CTLA-4 | 分子名称: | CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 | 著者 | Sonnen, A.F.-P, Yu, C, Evans, E.J, Stuart, D.I, Davis, S.J, Gilbert, R.J.C. | 登録日 | 2010-01-28 | 公開日 | 2010-04-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Domain Metastability: A Molecular Basis for Immunoglobulin Deposition? J.Mol.Biol., 399, 2010
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386D
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![BU of 386d by Molmil](/molmil-images/mine/386d) | THREE-DIMENSIONAL STRUCTURE AND REACTIVITY OF A PHOTOCHEMICAL CLEAVAGE AGENT BOUND TO DNA | 分子名称: | DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), N,N-BIS(3-AMINOPROPYL)-2-ANTHRAQUINONESULFONAMIDE | 著者 | Gasper, S.M, Armitage, B, Shui, X, Hu, G.G, Yu, C, Schuster, G, Williams, L.D. | 登録日 | 1998-03-11 | 公開日 | 1998-03-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Three-Dimensional Structure and Reactivity of a Photochemical Cleavage Agent Bound to DNA J.Am.Chem.Soc., 120, 1998
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1X32
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1KBS
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![BU of 1kbs by Molmil](/molmil-images/mine/1kbs) | SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 1 STRUCTURE | 分子名称: | CTX IV | 著者 | Jeng, J.Y, Kumar, T.K.S, Jayaraman, G, Yu, C. | 登録日 | 1996-07-22 | 公開日 | 1997-07-23 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid. Biochemistry, 36, 1997
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1KBT
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![BU of 1kbt by Molmil](/molmil-images/mine/1kbt) | SOLUTION STRUCTURE OF CARDIOTOXIN IV, NMR, 12 STRUCTURES | 分子名称: | CTX IV | 著者 | Jeng, J.Y, Kumar, T.K.S, Jayaraman, G, Yu, C. | 登録日 | 1996-07-22 | 公開日 | 1997-07-23 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid. Biochemistry, 36, 1997
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7D2T
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![BU of 7d2t by Molmil](/molmil-images/mine/7d2t) | Crystal structure of Rsu1/PINCH1_LIM45C complex | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, LIM and senescent cell antigen-like-containing domain protein 1, ... | 著者 | Yang, H, Wei, Z, Yu, C. | 登録日 | 2020-09-17 | 公開日 | 2021-02-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics. Elife, 10, 2021
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1X3P
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1WVZ
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![BU of 1wvz by Molmil](/molmil-images/mine/1wvz) | |
1X3Q
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4RJ6
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![BU of 4rj6 by Molmil](/molmil-images/mine/4rj6) | EGFR kinase (T790M/L858R) with inhibitor compound 4 | 分子名称: | Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ4
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![BU of 4rj4 by Molmil](/molmil-images/mine/4rj4) | EGFR kinase (T790M/L858R) with inhibitor compound 6 | 分子名称: | Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1-(propan-2-yl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ5
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![BU of 4rj5 by Molmil](/molmil-images/mine/4rj5) | EGFR kinase (T790M/L858R) with inhibitor compound 5 | 分子名称: | Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ8
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![BU of 4rj8 by Molmil](/molmil-images/mine/4rj8) | EGFR kinase (T790M/L858R) with inhibitor compound 8 | 分子名称: | 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, Epidermal growth factor receptor, SULFATE ION | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ7
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![BU of 4rj7 by Molmil](/molmil-images/mine/4rj7) | EGFR kinase (T790M/L858R) with inhibitor compound 1 | 分子名称: | 2,6-dichloro-N-{2-[(2-{[(2S)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide, Epidermal growth factor receptor, SULFATE ION | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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5YI4
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![BU of 5yi4 by Molmil](/molmil-images/mine/5yi4) | Solution Structure of the DISC1/Ndel1 complex | 分子名称: | Disrupted in schizophrenia 1 homolog,Nuclear distribution protein nudE-like 1 | 著者 | Ye, F, Yu, C, Yu, C, Zhang, M. | 登録日 | 2017-10-02 | 公開日 | 2017-11-15 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. Neuron, 96, 2017
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5KUP
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![BU of 5kup by Molmil](/molmil-images/mine/5kup) | Bruton's tyrosine kinase (BTK) with pyridazinone compound 9 | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one, GLYCEROL, ... | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2016-07-13 | 公開日 | 2016-09-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.389 Å) | 主引用文献 | Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations. Acs Chem.Biol., 11, 2016
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6O8U
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![BU of 6o8u by Molmil](/molmil-images/mine/6o8u) | Crystal structure of IRAK4 in complex with compound 23 | 分子名称: | GLYCEROL, Interleukin-1 receptor-associated kinase 4, N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... | 著者 | Kiefer, J.R, Yu, C, Drobnick, J, Bryan, M.C, Lupardus, P.J. | 登録日 | 2019-03-12 | 公開日 | 2019-05-22 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019
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2AL3
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![BU of 2al3 by Molmil](/molmil-images/mine/2al3) | Solution structure and backbone dynamics of an N-terminal ubiquitin-like domain in the GLUT4-tethering protein, TUG | 分子名称: | TUG long isoform | 著者 | Tettamanzi, M.C, Yu, C, Bogan, J.S, Hodsdon, M.E. | 登録日 | 2005-08-04 | 公開日 | 2006-03-21 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of an N-terminal ubiquitin-like domain in the GLUT4-regulating protein, TUG. Protein Sci., 15, 2006
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4RX5
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![BU of 4rx5 by Molmil](/molmil-images/mine/4rx5) | Bruton's tyrosine kinase (BTK) with pyridazinone compound 23 | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, N-(6-fluoro-2-methyl-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-1-benzothiophene-2-carboxamide, ... | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-12-08 | 公開日 | 2015-12-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.356 Å) | 主引用文献 | Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability. Bioorg.Med.Chem.Lett., 26, 2016
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6NSQ
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![BU of 6nsq by Molmil](/molmil-images/mine/6nsq) | Crystal structure of BRAF kinase domain bound to the inhibitor 2l | 分子名称: | 5-[(4-amino-1-ethyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine, Serine/threonine-protein kinase B-raf | 著者 | Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Zhang, C, Sicheri, F. | 登録日 | 2019-01-25 | 公開日 | 2019-06-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases. Acs Med.Chem.Lett., 10, 2019
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2B7D
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![BU of 2b7d by Molmil](/molmil-images/mine/2b7d) | Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model | 分子名称: | (2R)-2-[5-(5-CARBAMIMIDOYL-1H-BENZOIMIDAZOL-2-YL)-6,2'-DIHYDROXY-5'-UREIDOMETHYL-BIPHENYL-3-YL]-SUCCINIC ACID, Coagulation factor VII, Tissue factor | 著者 | Young, W.B, Mordenti, J, Torkelson, S, Shrader, W.D, Kolesnikov, A, Rai, R, Liu, L, Hu, H, Leahy, E.M, Green, M.J, Sprengeler, P.A, Katz, B.A, Yu, C, Janc, J.W, Elrod, K.C, Marzec, U.M, Hanson, S.R. | 登録日 | 2005-10-04 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. Bioorg.Med.Chem.Lett., 16, 2006
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2CXJ
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2CRS
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6U7V
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![BU of 6u7v by Molmil](/molmil-images/mine/6u7v) | xRRM structure of spPof8 | 分子名称: | NITRATE ION, Protein pof8 | 著者 | Kim, J.-K, Hu, X, Yu, C, Jun, H.-I, Liu, J, Sankaran, B, Huang, L, Qiao, F. | 登録日 | 2019-09-03 | 公開日 | 2020-09-09 | 最終更新日 | 2021-03-24 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Cell Rep, 33, 2020
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