2H6M
 
 | | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | | 分子名称: | N-ACETYL-LEUCYL-ALANYL-ALANYL-(N,N-DIMETHYL)-GLUTAMINE-(1,4-DIOXO-3,4-DIHYDRO-1H-PHTHALAZIN-2-YL)METHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Picornain 3C | | 著者 | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | | 登録日 | 2006-05-31 | | 公開日 | 2006-08-08 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
J.Mol.Biol., 361, 2006
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2DJ5
 | | Crystal Structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus | | 分子名称: | GLYCEROL, PHOSPHATE ION, Sirohydrochlorin cobaltochelatase | | 著者 | Yin, J, Cherney, M.M, James, M.N.G. | | 登録日 | 2006-03-31 | | 公開日 | 2006-09-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal Structure of the Vitamin B(12) Biosynthetic Cobaltochelatase, CbiX (S), from Archaeoglobus Fulgidus
J.STRUCT.FUNCT.GENOM., 7, 2006
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2A4O
 | | Dual modes of modification of Hepatitis A virus 3C protease by a serine derived beta-lactone: selective crytstallization and high resolution structure of the His102 adduct | | 分子名称: | ACETYL GROUP, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, PHENYLALANINE AMIDE, ... | | 著者 | Yin, J, Bergmann, E.M, Cherney, M.M, Lall, M.S, Jain, R.P, Vederas, J.C, James, M.N.G. | | 登録日 | 2005-06-29 | | 公開日 | 2005-12-27 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-derived beta-Lactone: Selective Crystallization and Formation of a Functional Catalytic Triad in the Active Site
J.MOL.BIOL., 354, 2005
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7SR8
 | | Molecular mechanism of the the wake-promoting agent TAK-925 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Hypocretin receptor type 2, ... | | 著者 | Yin, J, Chapman, K, Lian, P, De Brabander, J.K, Rosenbaum, D.M. | | 登録日 | 2021-11-08 | | 公開日 | 2022-06-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
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7K0V
 | | Crystal structure of bRaf in complex with inhibitor GNE-0749 | | 分子名称: | CHLORIDE ION, N-(3,3-dimethylbutyl)-N'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea, Non-specific serine/threonine protein kinase | | 著者 | Yin, J, Eigenbrot, C.E, Wang, W. | | 登録日 | 2020-09-06 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor.
J.Med.Chem., 64, 2021
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1TJN
 | | Crystal structure of hypothetical protein af0721 from Archaeoglobus fulgidus | | 分子名称: | Sirohydrochlorin cobaltochelatase | | 著者 | Yin, J, Xu, X.L, Cuff, M, Walker, J.R, Edwards, A, Savchenko, A, James, M.N.G, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2004-06-06 | | 公開日 | 2004-09-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal structure of af0721: a hypothetical protein bearing sequence similarity with class II chelatases in cobalamin synthesis
To be Published
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8V52
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7YPO
 | | Cryo-EM structure of baculovirus LEF-3 in complex with ssDNA | | 分子名称: | DNA (28-MER), Lef3 | | 著者 | Yin, J, Fu, Y, Rao, G, Li, Z, Cao, S. | | 登録日 | 2022-08-04 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural transitions during the cooperative assembly of baculovirus single-stranded DNA-binding protein on ssDNA.
Nucleic Acids Res., 50, 2022
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7YNY
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4QP1
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4QP9
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4QP7
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4QP3
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4QP4
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4QPA
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4QP6
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4QP8
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4QP2
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3TMO
 | | The catalytic domain of human deubiquitinase DUBA | | 分子名称: | OTU domain-containing protein 5 | | 著者 | Yin, J, Bosanac, I, Ma, X, Hymowitz, S, Starovasnik, M, Cochran, A. | | 登録日 | 2011-08-31 | | 公開日 | 2012-01-11 | | 最終更新日 | 2012-02-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Phosphorylation-dependent activity of the deubiquitinase DUBA.
Nat.Struct.Mol.Biol., 19, 2012
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4O6E
 | | Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2 | | 分子名称: | Mitogen-activated protein kinase 1, N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-2-(tetrahydro-2H-pyran-4-ylamino)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxamide | | 著者 | Yin, J, Wang, W. | | 登録日 | 2013-12-20 | | 公開日 | 2014-05-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Bioorg.Med.Chem.Lett., 24, 2014
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1NGX
 | | Chimeric Germline Fab 7g12 with jeffamine fragment bound | | 分子名称: | Germline Metal Chelatase Catalytic Antibody, Heavy chain, Light chain, ... | | 著者 | Yin, J, Andryski, S.E, Beuscher, A.B, Stevens, R.C, Schultz, P.G. | | 登録日 | 2002-12-18 | | 公開日 | 2003-03-18 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural evidence for substrate strain in antibody catalysis
Proc.Natl.Acad.Sci.USA, 100, 2003
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1N7M
 | | Germline 7G12 with N-methylmesoporphyrin | | 分子名称: | Germline Metal Chelatase Catalytic Antibody, chain H, chain L, ... | | 著者 | Yin, J, Andryski, S.E, Beuscher IV, A.E, Stevens, R.C, Schultz, P.G. | | 登録日 | 2002-11-15 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural evidence for substrate strain in antibody catalysis
Proc.Natl.Acad.Sci.USA, 100, 2003
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1NGW
 | | Chimeric Affinity Matured Fab 7g12 complexed with mesoporphyrin | | 分子名称: | Mature Metal Chelatase Catalytic Antibody, Heavy chain, Light chain, ... | | 著者 | Yin, J, Andryski, S.E, Beuscher IV, A.E, Stevens, R.C, Schultz, P.G. | | 登録日 | 2002-12-18 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural evidence for substrate strain in antibody catalysis
Proc.Natl.Acad.Sci.USA, 100, 2003
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1NGZ
 | | Chimeric Germline Fab 7g12-apo | | 分子名称: | Germline Metal Chelatase Catalytic Antibody, Heavy chain, Light chain | | 著者 | Yin, J, Andryski, S.A, Beuscher, A.B, Stevens, R.C, Schultz, P.G. | | 登録日 | 2002-12-18 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural evidence for substrate strain in antibody catalysis
Proc.Natl.Acad.Sci.USA, 100, 2003
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1NGY
 | | Chimeric Mature Fab 7g12-Apo | | 分子名称: | Mature Metal Chelatase Catalytic Antibody, Heavy chain, Light chain | | 著者 | Yin, J, Andryski, S.A, Beuscher, A.B, Stevens, R.C, Schultz, P.G. | | 登録日 | 2002-12-18 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural evidence for substrate strain in antibody catalysis
Proc.Natl.Acad.Sci.USA, 100, 2003
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