5YNI
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![BU of 5yni by Molmil](/molmil-images/mine/5yni) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAM and m7GpppG | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, S-ADENOSYLMETHIONINE, ZINC ION, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Chen, Y, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-24 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNQ
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![BU of 5ynq by Molmil](/molmil-images/mine/5ynq) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAH and m7GpppG | 分子名称: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-25 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.958 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YN5
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![BU of 5yn5 by Molmil](/molmil-images/mine/5yn5) | Crystal structure of MERS-CoV nsp10/nsp16 complex | 分子名称: | ZINC ION, nsp10 protein, nsp16 protein | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-24 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNF
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![BU of 5ynf by Molmil](/molmil-images/mine/5ynf) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to m7GpppA | 分子名称: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ZINC ION, nsp10 protein, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Chen, Y, Guo, D.Y. | 登録日 | 2017-10-24 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.791 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNP
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![BU of 5ynp by Molmil](/molmil-images/mine/5ynp) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to sinefungin and m7GpppA | 分子名称: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, SINEFUNGIN, ZINC ION, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-25 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNB
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![BU of 5ynb by Molmil](/molmil-images/mine/5ynb) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to Sinefungin | 分子名称: | SINEFUNGIN, ZINC ION, nsp10 protein, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Chen, Y, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-24 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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5YNM
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![BU of 5ynm by Molmil](/molmil-images/mine/5ynm) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAM and m7GpppA | 分子名称: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYLMETHIONINE, ZINC ION, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-24 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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4JZR
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![BU of 4jzr by Molmil](/molmil-images/mine/4jzr) | Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors | 分子名称: | 1,2-ETHANEDIOL, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, Egl nine homolog 1, ... | 著者 | Ma, Y, Yang, L. | 登録日 | 2013-04-03 | 公開日 | 2013-10-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors Bioorg.Med.Chem., 21, 2013
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5YNO
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![BU of 5yno by Molmil](/molmil-images/mine/5yno) | Crystal structure of MERS-CoV nsp16/nsp10 complex bound to SAH and m7GpppA | 分子名称: | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... | 著者 | Wei, S.M, Yang, L, Ke, Z.H, Guo, D.Y, Fan, C.P. | 登録日 | 2017-10-24 | 公開日 | 2018-12-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural insights into the molecular mechanism of MERS Coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex To Be Published
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6LN2
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![BU of 6ln2 by Molmil](/molmil-images/mine/6ln2) | Crystal structure of full length human GLP1 receptor in complex with Fab fragment (Fab7F38) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab7F38_heavy chain, Fab7F38_light chain, ... | 著者 | Wu, F, Yang, L, Hang, K, Laursen, M, Wu, L, Han, G.W, Ren, Q, Roed, N.K, Lin, G, Hanson, M, Jiang, H, Wang, M, Reedtz-Runge, S, Song, G, Stevens, R.C. | 登録日 | 2019-12-28 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Full-length human GLP-1 receptor structure without orthosteric ligands. Nat Commun, 11, 2020
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7V9A
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![BU of 7v9a by Molmil](/molmil-images/mine/7v9a) | biogenesis module of human telomerase holoenzyme | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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7V99
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![BU of 7v99 by Molmil](/molmil-images/mine/7v99) | catalytic core of human telomerase holoenzyme | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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6J3L
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![BU of 6j3l by Molmil](/molmil-images/mine/6j3l) | Solution structure of the N-terminal extended protuberant domain of eukaryotic ribosomal stalk protein P0 | 分子名称: | 60S acidic ribosomal protein P0 | 著者 | Choi, K.H.A, Lee, K.M, Yang, L, Wing-Heng Yu, C, Banfield, D.K, Ito, K, Uchiumi, T, Wong, K.B. | 登録日 | 2019-01-04 | 公開日 | 2019-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Mutagenesis Studies Evince the Role of the Extended Protuberant Domain of Ribosomal Protein uL10 in Protein Translation. Biochemistry, 58, 2019
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7DYG
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![BU of 7dyg by Molmil](/molmil-images/mine/7dyg) | |
7DYQ
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![BU of 7dyq by Molmil](/molmil-images/mine/7dyq) | Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile | 分子名称: | 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile, FE (III) ION, Lysine-specific demethylase 4D | 著者 | Wang, T, Yang, L. | 登録日 | 2021-01-22 | 公開日 | 2022-01-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile To Be Published
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7E49
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![BU of 7e49 by Molmil](/molmil-images/mine/7e49) | Crystal structure of MIF bound to compound10 | 分子名称: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, Macrophage migration inhibitory factor | 著者 | Fan, C.P, Guo, D.Y, Yang, L. | 登録日 | 2021-02-11 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.574 Å) | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E47
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![BU of 7e47 by Molmil](/molmil-images/mine/7e47) | Crystal structure of compound 6 bound to MIF | 分子名称: | (2S,3R,4R,5R,6R)-2-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-2-[[(2R,4R)-2-(4-hydroxyphenyl)-4,5-bis(oxidanyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-methyl-oxane-3,4,5-triol, CHLORIDE ION, Macrophage migration inhibitory factor | 著者 | Fan, C.P, Yang, L, Guo, D.Y. | 登録日 | 2021-02-10 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E4C
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![BU of 7e4c by Molmil](/molmil-images/mine/7e4c) | Crystal structure of MIF bound to compound11 | 分子名称: | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CHLORIDE ION, Macrophage migration inhibitory factor, ... | 著者 | Fan, C.P, Guo, D.Y, Yang, L. | 登録日 | 2021-02-11 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.644 Å) | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E4B
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![BU of 7e4b by Molmil](/molmil-images/mine/7e4b) | Crystal structure of MIF bound to compound 5 | 分子名称: | 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | 著者 | Fan, C.P, Guo, D.Y, Yang, L. | 登録日 | 2021-02-11 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.772 Å) | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E45
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![BU of 7e45 by Molmil](/molmil-images/mine/7e45) | Crystal structure of compound 7 bound to MIF | 分子名称: | (2R)-7-[(2R,3R,4R,5S,6S)-6-(hydroxymethyl)-3-[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-2-(4-methoxy-3-oxidanyl-phenyl)-5-oxidanyl-2,3-dihydrochromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor | 著者 | Fan, C.P, Yang, L. | 登録日 | 2021-02-10 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.433 Å) | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7E4A
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![BU of 7e4a by Molmil](/molmil-images/mine/7e4a) | Crystal structure of MIF bound to compound 13 | 分子名称: | CHLORIDE ION, Flavoxate, Macrophage migration inhibitory factor, ... | 著者 | Fa, C.P, Guo, D.Y, Yang, L. | 登録日 | 2021-02-11 | 公開日 | 2023-02-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.475 Å) | 主引用文献 | Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
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7VZB
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![BU of 7vzb by Molmil](/molmil-images/mine/7vzb) | Cryo-EM structure of C22:0-CoA bound human very long-chain fatty acid ABC transporter ABCD1 | 分子名称: | CHOLESTEROL HEMISUCCINATE, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] docosanethioate | 著者 | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2021-11-15 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
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7VX8
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![BU of 7vx8 by Molmil](/molmil-images/mine/7vx8) | Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1 | 著者 | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2021-11-12 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
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7VWC
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![BU of 7vwc by Molmil](/molmil-images/mine/7vwc) | Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1 | 分子名称: | Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, [(2R)-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-oxidanyl-propyl] octadecanoate | 著者 | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2021-11-10 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
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5HA9
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![BU of 5ha9 by Molmil](/molmil-images/mine/5ha9) | Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer | 分子名称: | Amitriptyline, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | 著者 | Fu, L, Peng, H, Zhang, L, Ouyang, L. | 登録日 | 2015-12-30 | 公開日 | 2016-03-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (4.01 Å) | 主引用文献 | Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. Sci Rep, 6, 2016
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