7X4Q
 
 | | LpCdnE UTP Mg complex | | 分子名称: | Cyclic dipyrimidine nucleotide synthase, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE | | 著者 | Chen, Y, Ko, T.P, Yang, C.S, Wang, Y.C, Hou, M.H. | | 登録日 | 2022-03-03 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases.
Nat Commun, 14, 2023
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4ZHT
 | | Crystal structure of UDP-GlcNAc 2-epimerase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-mannopyranose, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, CYTIDINE-5'-MONOPHOSPHATE-5-N-ACETYLNEURAMINIC ACID, ... | | 著者 | Chen, S.C, Yang, C.S, Ko, T.P, Chen, Y. | | 登録日 | 2015-04-27 | | 公開日 | 2016-06-01 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis.
Sci Rep, 6, 2016
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3TCP
 | | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569 | | 分子名称: | 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Liu, J, Yang, C, Simpson, C, DeRyckere, D, Van Deusen, A, Miley, M, Kireev, D.B, Norris-Drouin, J, Sather, S, Hunter, D, Patel, H.S, Janzen, W.P, Machius, M, Johnson, G, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | | 登録日 | 2011-08-09 | | 公開日 | 2012-06-20 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
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3ZIF
 | | Cryo-EM structures of two intermediates provide insight into adenovirus assembly and disassembly | | 分子名称: | HEXON PROTEIN, PENTON PROTEIN, PIX, ... | | 著者 | Cheng, L, Huang, X, Li, X, Xiong, W, Sun, W, Yang, C, Zhang, K, Wang, Y, Liu, H, Ji, G, Sun, F, Zheng, C, Zhu, P. | | 登録日 | 2013-01-09 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-Em Structures of Two Bovine Adenovirus Type 3 Intermediates
Virology, 450, 2014
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3OQT
 | | Crystal structure of Rv1498A protein from mycobacterium tuberculosis | | 分子名称: | CHLORIDE ION, Rv1498A PROTEIN, SODIUM ION | | 著者 | Liu, F, Xiong, J, Kumar, S, Yang, C, Li, S, Ge, S, Xia, N, Swaminathan, K. | | 登録日 | 2010-09-04 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Structural and biophysical characterization of Mycobacterium tuberculosis dodecin Rv1498A.
J.Struct.Biol., 175, 2011
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3NUQ
 | | Structure of a putative nucleotide phosphatase from Saccharomyces cerevisiae | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Dong, A, Yang, C, Singer, A.U, Evdokimova, E, Kudritsdka, M, Brown, G, Edwards, A.M, Joachimiak, A, Savchenko, A, Yakunin, A.F, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2010-07-07 | | 公開日 | 2010-08-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of a putative nucleotide phosphatase from Saccharomyces cerevisiae
To be Published
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3VPM
 | | Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant | | 分子名称: | FE (III) ION, MAGNESIUM ION, Ribonucleoside-diphosphate reductase subunit M2 | | 著者 | Chen, X, Xu, Z, Liu, H, Zhang, L, Chen, B, Zhu, L, Yang, C, Zhu, W, Shao, J. | | 登録日 | 2012-03-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Essential role of E106 in the proton-coupled electron transfer in human ribonucleotide reductase M2 subunit
To be Published
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3VPO
 | | Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant | | 分子名称: | FE (III) ION, MAGNESIUM ION, Ribonucleoside-diphosphate reductase subunit M2 | | 著者 | Chen, X, Xu, Z, Liu, H, Zhang, L, Chen, B, Zhu, L, Yang, C, Zhu, W, Shao, J. | | 登録日 | 2012-03-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Essential role of E106 in the proton-coupled electron transfer in human
to be published
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3VPN
 | | Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) mutant | | 分子名称: | FE (III) ION, MAGNESIUM ION, Ribonucleoside-diphosphate reductase subunit M2 | | 著者 | Chen, X, Xu, Z, Liu, H, Zhang, L, Chen, B, Zhu, L, Yang, C, Zhu, W, Shao, J. | | 登録日 | 2012-03-05 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Essential role of E106 in the proton-coupled electron transfer in human
to be published
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4IWG
 | | Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii (in C2221 form) | | 分子名称: | UPF0135 protein MJ0927 | | 著者 | Kuan, S.M, Chen, S.C, Yang, C.S, Chen, Y.R, Liu, Y.H, Chen, Y. | | 登録日 | 2013-01-23 | | 公開日 | 2014-01-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.472 Å) | | 主引用文献 | Crystal structure of a conserved hypothetical protein MJ0927 from Methanocaldococcus jannaschii reveals a novel quaternary assembly in the Nif3 family.
Biomed Res Int, 2014, 2014
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4IXA
 | | Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis | | 分子名称: | Response regulator SaeR | | 著者 | Chen, Y.R, Chen, S.C, Yang, C.S, Kuan, S.M, Liu, Y.H, Chen, Y. | | 登録日 | 2013-01-24 | | 公開日 | 2014-01-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis
To be Published
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4NEQ
 | | The structure of UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, UDP-N-acetylglucosamine 2-epimerase | | 著者 | Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | | 登録日 | 2013-10-29 | | 公開日 | 2014-04-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc.
Proteins, 82, 2014
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4K7E
 | | Crystal structure of Junin virus nucleoprotein | | 分子名称: | Nucleoprotein | | 著者 | Zhang, Y.J, Li, L, Liu, X, Dong, S.S, Wang, W.M, Huo, T, Rao, Z.H, Yang, C. | | 登録日 | 2013-04-17 | | 公開日 | 2013-08-07 | | 最終更新日 | 2013-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of Junin virus nucleoprotein
J.Gen.Virol., 94, 2013
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4IWM
 | | Crystal Structure of the Conserved Hypothetical Protein MJ0927 from Methanocaldococcus jannaschii (in P21 form) | | 分子名称: | UPF0135 protein MJ0927 | | 著者 | Kuan, S.M, Chen, S.C, Yang, C.S, Chen, Y.R, Liu, Y.H, Chen, Y. | | 登録日 | 2013-01-24 | | 公開日 | 2014-01-29 | | 最終更新日 | 2021-04-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of a conserved hypothetical protein MJ0927 from Methanocaldococcus jannaschii reveals a novel quaternary assembly in the Nif3 family.
Biomed Res Int, 2014, 2014
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4Q47
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8WEW
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8W7R
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4Q48
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4NES
 | | Crystal structure of Methanocaldococcus jannaschii UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP | | 分子名称: | UDP-N-acetylglucosamine 2-epimerase, URIDINE-5'-DIPHOSPHATE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | 著者 | Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | | 登録日 | 2013-10-30 | | 公開日 | 2014-04-23 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc.
Proteins, 82, 2014
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4QI1
 | | Crystal structure of H. walsbyi bacteriorhodopsin | | 分子名称: | Bacteriorhodopsin-I, GLYCEROL, RETINAL, ... | | 著者 | Wang, A.H.J, Hsu, M.F, Yang, C.S, Fu, H.Y. | | 登録日 | 2014-05-30 | | 公開日 | 2015-07-29 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and Functional Studies of a Newly Grouped Haloquadratum walsbyi Bacteriorhodopsin Reveal the Acid-resistant Light-driven Proton Pumping Activity.
J. Biol. Chem., 290, 2015
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4QID
 | | Crystal structure of Haloquadratum walsbyi bacteriorhodopsin | | 分子名称: | ACETATE ION, Bacteriorhodopsin-I, RETINAL, ... | | 著者 | Wang, A.H.J, Hsu, M.F, Yang, C.S, Fu, H.Y. | | 登録日 | 2014-05-30 | | 公開日 | 2015-07-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | An acid-tolerant light-driven proton pump
To be Published
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8TFT
 | | Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, ... | | 著者 | Oganesyan, V.Y, van Dyk, N, Mazor, Y, Yang, C. | | 登録日 | 2023-07-11 | | 公開日 | 2024-08-28 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
To be published
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8TBB
 | | F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F9S Fab heavy chain, F9S Fab light chain, ... | | 著者 | Oganesyan, V, van Dyk, N, Mazor, Y, Yang, C. | | 登録日 | 2023-06-28 | | 公開日 | 2024-08-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
To be published
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7DDC
 | | Crystal structure of SARS-CoV-2 main protease in complex with Tafenoquine | | 分子名称: | 3C-like proteinase, Tafenoquine | | 著者 | Chen, Y, Wang, Y.C, Yang, C.S, Hung, M.C. | | 登録日 | 2020-10-28 | | 公開日 | 2021-11-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | | 主引用文献 | Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2.
J.Biol.Chem., 298, 2022
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7CAM
 | | SARS-CoV-2 main protease (Mpro) apo structure (space group P212121) | | 分子名称: | 3C-like proteinase | | 著者 | Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chou, Y.Z, Chen, Y. | | 登録日 | 2020-06-09 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug.
Am J Cancer Res, 10, 2020
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